Dave Curtis
@davecurtis314.bsky.social
Human genetics research at the UCL Genetics Institute, retired psychiatrist. Publications here: https://scholar.google.co.uk/citations?hl=en&user=Vrr4Ig0AAAAJ&view_op=list_works&sortby=pubdate
My review of hypertension genetics just published in Pulse:
karger.com/pls/article/...
Some interesting findings, certainly. But I wonder how "useful" they really are??
karger.com/pls/article/...
Some interesting findings, certainly. But I wonder how "useful" they really are??
Genetic Variants Associated with Hypertension Risk: Progress and Implications
Abstract. Background: Genetic variants causing diseases with hypertension as a secondary feature have previously been identified. Studies focussing on primary hypertension have utilised common and lat...
karger.com
February 26, 2024 at 11:43 AM
My review of hypertension genetics just published in Pulse:
karger.com/pls/article/...
Some interesting findings, certainly. But I wonder how "useful" they really are??
karger.com/pls/article/...
Some interesting findings, certainly. But I wonder how "useful" they really are??
New publication reporting attempts to detect effects of recessively acting coding variants on risk of clinically important phenotypes: 🧪🤝🖥️ 🧬
karger.com/hhe/article/...
karger.com/hhe/article/...
Investigation of recessive effects of coding variants on common clinical phenotypes in exome-sequenced UK Biobank participants
Abstract. Introduction Previous studies have demonstrated effects of rare coding variants on common, clinically relevant phenotypes although the additive burden of these variants makes only a small co...
karger.com
February 15, 2024 at 2:53 PM
New publication reporting attempts to detect effects of recessively acting coding variants on risk of clinically important phenotypes: 🧪🤝🖥️ 🧬
karger.com/hhe/article/...
karger.com/hhe/article/...
Word cloud of my publication titles
shiny.rcg.sfu.ca/u/rdmorin/sc...
shiny.rcg.sfu.ca/u/rdmorin/sc...
February 9, 2024 at 6:49 PM
Word cloud of my publication titles
shiny.rcg.sfu.ca/u/rdmorin/sc...
shiny.rcg.sfu.ca/u/rdmorin/sc...
In a focused review, UCL student Lea Heinzer provides a thorough account of the insights into schizophrenia pathogenesis provided by genetic studies identifying genes in which sequence variants can exert a dramatic effect on risk.
🧪🧬🖥️
www.oaepublish.com/articles/jtg...
🧪🧬🖥️
www.oaepublish.com/articles/jtg...
What have genetic studies of rare sequence variants taught us about the aetiology of schizophrenia?
With a population prevalence of 1%, schizophrenia is widespread, yet the aetiology of this psychiatric disorder remains elusive. There is an evident genetic component of schizophrenia, with heritabili...
www.oaepublish.com
January 15, 2024 at 12:59 PM
In a focused review, UCL student Lea Heinzer provides a thorough account of the insights into schizophrenia pathogenesis provided by genetic studies identifying genes in which sequence variants can exert a dramatic effect on risk.
🧪🧬🖥️
www.oaepublish.com/articles/jtg...
🧪🧬🖥️
www.oaepublish.com/articles/jtg...
London's Trafalgar Square packed with supporters of Israel, calling for the release of the hostages held by Hamas.
January 14, 2024 at 3:12 PM
London's Trafalgar Square packed with supporters of Israel, calling for the release of the hostages held by Hamas.
Reposted by Dave Curtis
This raises doubts about the many prior studies using similar data and models to recover in-credible accuracies in very small samples.
January 11, 2024 at 11:57 AM
This raises doubts about the many prior studies using similar data and models to recover in-credible accuracies in very small samples.
In a focused review, UCL student Lea Heinzer provides a thorough account of the insights into schizophrenia pathogenesis provided by genetic studies identifying genes in which sequence variants can exert a dramatic effect on risk.
www.oaepublish.com/articles/jtg...
www.oaepublish.com/articles/jtg...
What have genetic studies of rare sequence variants taught us about the aetiology of schizophrenia?
With a population prevalence of 1%, schizophrenia is widespread, yet the aetiology of this psychiatric disorder remains elusive. There is an evident genetic component of schizophrenia, with heritabili...
www.oaepublish.com
January 11, 2024 at 11:42 AM
In a focused review, UCL student Lea Heinzer provides a thorough account of the insights into schizophrenia pathogenesis provided by genetic studies identifying genes in which sequence variants can exert a dramatic effect on risk.
www.oaepublish.com/articles/jtg...
www.oaepublish.com/articles/jtg...
In the heart of Westminster,, Together for Humanity, affirming that Londoners of all faiths will continue to stand together against hatred.
December 3, 2023 at 3:11 PM
In the heart of Westminster,, Together for Humanity, affirming that Londoners of all faiths will continue to stand together against hatred.
This is nuts! Why did this woman with self-confessed severe cognitive impairment get appointed as a minister? And why on earth did she accept the job? It's no wonder she made such a terrible hash of things. We're still suffering the results of her incompetence.
www.bbc.co.uk/news/uk-poli...
www.bbc.co.uk/news/uk-poli...
Therese Coffey: Brain abscess from stress left me 'close to dying'
The Suffolk MP spent a month in hospital in 2018 and had to rebuild "aspects" of her memory.
www.bbc.co.uk
December 3, 2023 at 11:44 AM
This is nuts! Why did this woman with self-confessed severe cognitive impairment get appointed as a minister? And why on earth did she accept the job? It's no wonder she made such a terrible hash of things. We're still suffering the results of her incompetence.
www.bbc.co.uk/news/uk-poli...
www.bbc.co.uk/news/uk-poli...
Here's me talking about the effects of rare coding variants on risk of type 2 diabetes.
Aimed at the non-specialist, it gives an account of the kind of work I've been doing over the last few years.
And whether personalised medicine will ever be a thing.
faculti.net/analysis-of-...
🧪🧬🖥️
Aimed at the non-specialist, it gives an account of the kind of work I've been doing over the last few years.
And whether personalised medicine will ever be a thing.
faculti.net/analysis-of-...
🧪🧬🖥️
Analysis of rare coding variants reveals novel genetic risk factors for type 2 diabetes | Faculti
David Curtis explores findings from a previous study, utilizing an expanded sample of 470,000 exome-sequenced individuals. The aim was to identify genes linked to type 2 diabetes (T2D) and examine the...
faculti.net
November 30, 2023 at 4:10 PM
Here's me talking about the effects of rare coding variants on risk of type 2 diabetes.
Aimed at the non-specialist, it gives an account of the kind of work I've been doing over the last few years.
And whether personalised medicine will ever be a thing.
faculti.net/analysis-of-...
🧪🧬🖥️
Aimed at the non-specialist, it gives an account of the kind of work I've been doing over the last few years.
And whether personalised medicine will ever be a thing.
faculti.net/analysis-of-...
🧪🧬🖥️
Just published in Pulse - analysis of exome sequence data identifies novel genes affecting risk of hypertension. Variants damaging genes for two different guanylate cyclases increase risk. And variants damaging gene for dopamine beta hydroxylase are protective.
karger.com/pls/article/...
🧪🧬🖥️
karger.com/pls/article/...
🧪🧬🖥️
Analysis of Rare Variants in 470,000 Exome-Sequenced UK Biobank Participants Implicates Novel Genes ...
Abstract. Introduction: A previous study of 200,000 exome-sequenced UK Biobank participants to test for association of rare coding variants with hypertension implicated two genes at exome-wide signifi...
karger.com
November 29, 2023 at 11:33 AM
Just published in Pulse - analysis of exome sequence data identifies novel genes affecting risk of hypertension. Variants damaging genes for two different guanylate cyclases increase risk. And variants damaging gene for dopamine beta hydroxylase are protective.
karger.com/pls/article/...
🧪🧬🖥️
karger.com/pls/article/...
🧪🧬🖥️
New preprint! Assessment of AlphaMissense against dozens of other methods. Overall AlphaMissense has most power to detect association of rare coding variants with common clinical phenotypes. But varies a lot between genes - for some, other methods are much better. www.medrxiv.org/content/10.1...
🧪🧬🖥️
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Assessment of ability of AlphaMissense to identify variants affecting susceptibility to common disea...
medRxiv - The Preprint Server for Health Sciences
www.medrxiv.org
November 27, 2023 at 11:30 AM
New preprint! Assessment of AlphaMissense against dozens of other methods. Overall AlphaMissense has most power to detect association of rare coding variants with common clinical phenotypes. But varies a lot between genes - for some, other methods are much better. www.medrxiv.org/content/10.1...
🧪🧬🖥️
🧪🧬🖥️
Reposted by Dave Curtis
“And that, really, is the problem: the lack of due diligence means the rewards for bending or breaking the scientific rules tend to outweigh the incentives to observe them” www.ft.com/content/c886...
There is a scientific fraud epidemic — and we are ignoring the cure
Rooting out manipulation should not depend on dedicated amateurs who take personal legal risks for the greater good
www.ft.com
November 22, 2023 at 9:11 AM
“And that, really, is the problem: the lack of due diligence means the rewards for bending or breaking the scientific rules tend to outweigh the incentives to observe them” www.ft.com/content/c886...
Reposted by Dave Curtis
Please, please can more people start using Pubpeer - pubpeer.com - to highlight and document problems in the published literature. Future changes will need a body of evidence. "The overarching goal of the Foundation is to improve the quality of scientific research by enabling innovative...."
November 22, 2023 at 9:22 AM
Please, please can more people start using Pubpeer - pubpeer.com - to highlight and document problems in the published literature. Future changes will need a body of evidence. "The overarching goal of the Foundation is to improve the quality of scientific research by enabling innovative...."
Interesting to see the debate about routine genome sequencing of newborn babies now happening in America.
In a BMJ debate article a couple of years ago, I expressed similar concerns about the proposed program in the UK:
newjerseymonitor.com/2023/11/14/c...
www.ucl.ac.uk/biosciences/...
🧪🧬🖥️
In a BMJ debate article a couple of years ago, I expressed similar concerns about the proposed program in the UK:
newjerseymonitor.com/2023/11/14/c...
www.ucl.ac.uk/biosciences/...
🧪🧬🖥️
Civil rights concerns grow over baby blood tests, as state mulls genomic sequencing - New Jersey Mon...
State health officials will consider adding genomic sequencing to the mandatory baby blood testing hospitals do to test for disease.
newjerseymonitor.com
November 19, 2023 at 4:56 PM
Interesting to see the debate about routine genome sequencing of newborn babies now happening in America.
In a BMJ debate article a couple of years ago, I expressed similar concerns about the proposed program in the UK:
newjerseymonitor.com/2023/11/14/c...
www.ucl.ac.uk/biosciences/...
🧪🧬🖥️
In a BMJ debate article a couple of years ago, I expressed similar concerns about the proposed program in the UK:
newjerseymonitor.com/2023/11/14/c...
www.ucl.ac.uk/biosciences/...
🧪🧬🖥️
Along with the report that child mortality in the UK has increase by around 10% in a year, this is a real horror story. Around 2/3 of new UK doctors qualified abroad. We're just relying on other (poorer) countries to train our doctors for us. Disgusting parasitism.
www.bbc.co.uk/news/health-...
www.bbc.co.uk/news/health-...
Overseas doctors will remain 'crucial' despite recruitment drive - regulator
The General Medical Council says efforts to recruit more UK doctors will take years to take effect.
www.bbc.co.uk
November 13, 2023 at 12:11 AM
Along with the report that child mortality in the UK has increase by around 10% in a year, this is a real horror story. Around 2/3 of new UK doctors qualified abroad. We're just relying on other (poorer) countries to train our doctors for us. Disgusting parasitism.
www.bbc.co.uk/news/health-...
www.bbc.co.uk/news/health-...
Seriously, how does this happen? For socks, I only buy sets of black ones to keep things simple. Now look what's left in my wardrobe. Nine black socks and not one pair.
November 12, 2023 at 6:07 PM
Seriously, how does this happen? For socks, I only buy sets of black ones to keep things simple. Now look what's left in my wardrobe. Nine black socks and not one pair.
Materialism is both incoherent and massively counter-intuitive, directly contradicting people's lived experience. So it's hardly surprising that even those who profess to believe it struggle not to make occasional heretical comments.
🧪🤝🖥️ #NeuroSkyEnce #PsychSciSky
direct.mit.edu/jocn/article...
🧪🤝🖥️ #NeuroSkyEnce #PsychSciSky
direct.mit.edu/jocn/article...
“Me & My Brain”: Exposing Neuroscience's Closet Dualism
Abstract. Our intuitive concept of the relations between brain and mind is increasingly challenged by the scientific world view. Yet, although few neuroscientists openly endorse Cartesian dualism, car...
direct.mit.edu
November 9, 2023 at 1:45 PM
Materialism is both incoherent and massively counter-intuitive, directly contradicting people's lived experience. So it's hardly surprising that even those who profess to believe it struggle not to make occasional heretical comments.
🧪🤝🖥️ #NeuroSkyEnce #PsychSciSky
direct.mit.edu/jocn/article...
🧪🤝🖥️ #NeuroSkyEnce #PsychSciSky
direct.mit.edu/jocn/article...
Sigh. Another paper which fails to cite my incredibly relevant contribution to the field which undermines the main conclusion of the new paper. Oh well. Worth a comment on PubPeer, I should think. 🧪🖥️🧬
pubpeer.com/publications...
pubpeer.com/publications...
PubPeer - Identification of circulating proteins associated with gener...
There are comments on PubPeer for publication: Identification of circulating proteins associated with general cognitive function among middle-aged and older adults (2023)
pubpeer.com
November 9, 2023 at 12:23 PM
Sigh. Another paper which fails to cite my incredibly relevant contribution to the field which undermines the main conclusion of the new paper. Oh well. Worth a comment on PubPeer, I should think. 🧪🖥️🧬
pubpeer.com/publications...
pubpeer.com/publications...
We're in the twenty-first century. Why on earth have we got a "king"?
November 8, 2023 at 10:18 PM
We're in the twenty-first century. Why on earth have we got a "king"?
Depressing that these papers from 10 and 20 years ago seem more salient today than ever - why is so much terrible science still funded and published?
www.nature.com/articles/nrn...
www.bmj.com/content/308/...
www.nature.com/articles/nrn...
www.bmj.com/content/308/...
The scandal of poor medical research
We need less research, better research, and research done for the right reasons
What should we think about a doctor who uses the wrong treatment, either wilfully or through ignorance, or who uses the...
www.bmj.com
November 8, 2023 at 8:48 PM
Depressing that these papers from 10 and 20 years ago seem more salient today than ever - why is so much terrible science still funded and published?
www.nature.com/articles/nrn...
www.bmj.com/content/308/...
www.nature.com/articles/nrn...
www.bmj.com/content/308/...
I don't know if Emily Maitlin has had her account on X hacked, but either way this is a striking video:
x.com/maitlis/stat...
x.com/maitlis/stat...
November 6, 2023 at 11:44 AM
I don't know if Emily Maitlin has had her account on X hacked, but either way this is a striking video:
x.com/maitlis/stat...
x.com/maitlis/stat...
I would hope that one thing we could all agree on is that a desirable outcome is that Hamas is swiftly defeated. Good for Israelis, good for Palestinians. Any objectors?
November 4, 2023 at 7:46 PM
I would hope that one thing we could all agree on is that a desirable outcome is that Hamas is swiftly defeated. Good for Israelis, good for Palestinians. Any objectors?
A journal editor has emailed to say they've invited ** 180 ** reviewers to review our (invited) submission. Of whom just 5 agreed. Of whom just 1 has actually provided a review.
🧪🧬🖥️
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November 3, 2023 at 12:06 PM
A journal editor has emailed to say they've invited ** 180 ** reviewers to review our (invited) submission. Of whom just 5 agreed. Of whom just 1 has actually provided a review.
🧪🧬🖥️
🧪🧬🖥️
Reposted by Dave Curtis
