Escalante Lab
@crescalante.bsky.social
Escalante Group at VCU School of Medicine, X-ray Crystallography, Cryo-EM, SAXS, AUC, AAV, Transcription Factors. All opinions, my own.
Reposted by Escalante Lab
Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows. Gift link: nyti.ms/44KFFFv
Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows
An analysis by the American Association for the Advancement of Science shows the impact of the administration’s budget plan on the kind of studies that produce the most breakthroughs.
nyti.ms
July 10, 2025 at 3:42 PM
Trump Seeks to Cut Basic Scientific Research by Roughly One-Third, Report Shows. Gift link: nyti.ms/44KFFFv
Another terrible day for young scientists. The NIH just sent termination notices for the MARC, PREP, IMSD, IRACDA and Bridges programs.
April 2, 2025 at 6:10 PM
Another terrible day for young scientists. The NIH just sent termination notices for the MARC, PREP, IMSD, IRACDA and Bridges programs.
Today is the anniversary of the release of John Coltrane's A Love Supreme. The whole album is here for everyone's enjoyment.
www.youtube.com/watch?v=ll3C...
www.youtube.com/watch?v=ll3C...
John Coltrane - A Love Supreme [Full Album] (1965)
YouTube video by Jazzaddict 98
www.youtube.com
February 7, 2025 at 5:22 PM
Today is the anniversary of the release of John Coltrane's A Love Supreme. The whole album is here for everyone's enjoyment.
www.youtube.com/watch?v=ll3C...
www.youtube.com/watch?v=ll3C...
New manuscript from Lab is now up in Nucleic Acids Research.
Congratulations to all involved!
academic.oup.com/nar/article/...
Congratulations to all involved!
academic.oup.com/nar/article/...
Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting
Abstract. The Rep68 protein from Adeno-Associated Virus (AAV) is a multifunctional SF3 helicase that performs most of the DNA transactions necessary for th
academic.oup.com
February 7, 2025 at 4:18 PM
New manuscript from Lab is now up in Nucleic Acids Research.
Congratulations to all involved!
academic.oup.com/nar/article/...
Congratulations to all involved!
academic.oup.com/nar/article/...
This new paper in Science is groundbreaking, congratulations to all authors. One more application using AAV:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts...
www.science.org
February 7, 2025 at 4:15 PM
This new paper in Science is groundbreaking, congratulations to all authors. One more application using AAV:
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Escalante Lab
“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.”
www.researchamerica.org/2023-oped-us...
www.researchamerica.org/2023-oped-us...
Research supported by NIH has led more than 100 Nobel Prizes and has supported more than 99% of drugs approved by federal regulators from 2010 to 2019.
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
Long a ‘Crown Jewel’ of Government, N.I.H. Is Now a Target
nytimes.com
December 1, 2024 at 11:58 PM
“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.”
www.researchamerica.org/2023-oped-us...
www.researchamerica.org/2023-oped-us...