“Hidden Guests” explores how the emerging field of microchimerism is upending medicine, genetics, and our sense of self.

Abstract. First-line cancer treatment frequently fails due to initially rare therapeutic resistance. An important clinical question is then how to schedule

L’EPHE − PSL propose une formation pratique à l’utilisation du logiciel libre R pour la gestion et la manipulation des données avant l’analyse statistique (non traitée dans cette formation).Le contenu...

A two-year position for a postdoctoral researcher is open at the “Bees and Environment” research unit (Avignon, France) affiliated to INRAE (French National Research Institute for Agriculture, Food and Environment), one of the leading institute in the world for the study of relationships between agriculture, environment and food. The postdoc will work on the physiological mechanisms, microbial diversity and molecular adaptation features of collective defenses against diseases in social animals.Background & dutiesInvasive species that reveal themselves as new parasites disrupt established host-pathogen dynamics and can cause immense economic damage. Despite their high susceptibility to invasions and disease spread, many social animals have evolved mechanisms that allow effective defence at the group level. Such defences have been described across the animal kingdom, especially within social insect species, and are known to involve chemical communication. Our team aims to understand the mechanisms that underpin collective behavioural and physiological defences against unhealthy brood in honey bee colonies, in the context of the invasion by the parasite Varroa destructor.Within this project, the postdoc will lead research to decipher the collective defences that are developed against brood diseases, with a particular interest about varroa. The focus will be placed around the understanding of physiological and behavioural mechanisms that are at the basis of honey bee resistance to this parasitic mite. Investigations will be performed through chemical ecology experiments, as well as transcriptomics and metagenomics. The overall goal is to determine the semiochemicals drivers of host defence towards parasitic infestation, to investigate the potential role of microbiome in resistance triggering, as well as to characterise physiological features of individual bees that are actively involved in the host response.Research environment and work conditionsYou will join the “Bees and Environment” research unit of INRAE in Avignon (France), which develops a wide range of research programs to study honey bee and wild bee populations, in the context of sustainable farming and global change. This postdoc project is part of an Interreg Alcotra grant (2023-2027 – Meliorapi) and an ERC Starting grant (2024-2028 – Bee Healthy) led by Fanny Mondet. You will work in close collaboration with our beekeeping technicians, students and postdocs of the team, our research assistant in chemical ecology and our engineer in honey bee genetics. You will benefit from all the lab and field work facilities of the unit, including our experimental apiary and chemical ecology platform. Additionally, the metagenomic work will be developed in close collaboration with the BeeGEES team of the GenPhySE research unit (INRAE) in Toulouse, especially Thibault Leroy. The BeeGEES team is one of the global leaders in honey bee genomics and have recently developed large-scale metagenomic projects. The postdoctoral researcher will be expected to spend periods in Toulouse to benefit from the local expertise in metagenomics, as well as the access to the genomic facilities.The contract will be for 2 years, starting in March 2026.Salary and benefits are according to INRAE rules in France (monthly gross salary ~ 3,100 €).