Nicolas Bierne
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couplingdmi.bsky.social
Nicolas Bierne
@couplingdmi.bsky.social
CNRS researcher at @isemevol.bsky.social Montpellier
Population Genetics, Evolution, Marine Biology, Transmissible Cancers
#PopGen #Hybridization #Introgression #MarEvol #Transcan #MusselsAreCool
The disappearance (much better word than extinction) of the Neanderthals could be attributed solely to admixture and an asymmetrical demographic wave. The hypothesis takes the form of equations and receives support in this interesting article.
www.nature.com/articles/s41...
A simple analytical model for Neanderthal disappearance due to genetic dilution by recurrent small-scale immigrations of modern humans - Scientific Reports
Scientific Reports - A simple analytical model for Neanderthal disappearance due to genetic dilution by recurrent small-scale immigrations of modern humans
www.nature.com
November 10, 2025 at 9:26 AM
Reposted by Nicolas Bierne
New paper published together with John Welch on hybrid fitness and how it depends on ploidy and # of distinct ancestries, incl some remarkable fits of data & theory 😶. Keen to hear any thoughts/comments/questions! doi.org/10.1093/gene... Thanks to the team @ Genetics for the smooth experience :)
Predicting Hybrid Fitness: The Effects of Ploidy and Complex Ancestry
Abstract. Hybridization between divergent populations places alleles in novel genomic contexts. This can inject adaptive variation – which is useful for br
doi.org
November 9, 2025 at 1:04 PM
Again in Roscoff 🤩
November 6, 2025 at 8:31 AM
Reposted by Nicolas Bierne
Reminder: we still welcome applications! 📩
2-year postdoctoral position available in Fanny Mondet’s group (Avignon, France) as part of her ERC project, in collaboration with our BeeGEES team in Toulouse
Interested in chemical ecology, transcriptomics, microbiomes, and honey bees? 🐝
Application deadline: November 27, 2025

Thanks for sharing!
Postdoctoral position in chemical ecology and genomics: Mechanisms of honey bee resistance to varroa
A two-year position for a postdoctoral researcher is open at the “Bees and Environment” research unit (Avignon, France) affiliated to INRAE (French National Research Institute for Agriculture, Food and Environment), one of the leading institute in the world for the study of relationships between agriculture, environment and food. The postdoc will work on the physiological mechanisms, microbial diversity and molecular adaptation features of collective defenses against diseases in social animals.Background & dutiesInvasive species that reveal themselves as new parasites disrupt established host-pathogen dynamics and can cause immense economic damage. Despite their high susceptibility to invasions and disease spread, many social animals have evolved mechanisms that allow effective defence at the group level. Such defences have been described across the animal kingdom, especially within social insect species, and are known to involve chemical communication. Our team aims to understand the mechanisms that underpin collective behavioural and physiological defences against unhealthy brood in honey bee colonies, in the context of the invasion by the parasite Varroa destructor.Within this project, the postdoc will lead research to decipher the collective defences that are developed against brood diseases, with a particular interest about varroa. The focus will be placed around the understanding of physiological and behavioural mechanisms that are at the basis of honey bee resistance to this parasitic mite. Investigations will be performed through chemical ecology experiments, as well as transcriptomics and metagenomics. The overall goal is to determine the semiochemicals drivers of host defence towards parasitic infestation, to investigate the potential role of microbiome in resistance triggering, as well as to characterise physiological features of individual bees that are actively involved in the host response.Research environment and work conditionsYou will join the “Bees and Environment” research unit of INRAE in Avignon (France), which develops a wide range of research programs to study honey bee and wild bee populations, in the context of sustainable farming and global change. This postdoc project is part of an Interreg Alcotra grant (2023-2027 – Meliorapi) and an ERC Starting grant (2024-2028 – Bee Healthy) led by Fanny Mondet. You will work in close collaboration with our beekeeping technicians, students and postdocs of the team, our research assistant in chemical ecology and our engineer in honey bee genetics. You will benefit from all the lab and field work facilities of the unit, including our experimental apiary and chemical ecology platform. Additionally, the metagenomic work will be developed in close collaboration with the BeeGEES team of the GenPhySE research unit (INRAE) in Toulouse, especially Thibault Leroy. The BeeGEES team is one of the global leaders in honey bee genomics and have recently developed large-scale metagenomic projects. The postdoctoral researcher will be expected to spend periods in Toulouse to benefit from the local expertise in metagenomics, as well as the access to the genomic facilities.The contract will be for 2 years, starting in March 2026.Salary and benefits are according to INRAE rules in France (monthly gross salary ~ 3,100 €).
jobs.inrae.fr
November 6, 2025 at 7:36 AM
Reposted by Nicolas Bierne
The second Ph.D. chapter of Diane's thesis is out as a preprint. She studied the joint evolution of autopolyploidy and self-fertilization under a gametophytic self-incompatibility context.

Feel free to comment, and congratulations, Diane!

www.biorxiv.org/content/10.1...
Autopolyploid establishment under gametophytic self-incompatibility: the impact of self-fertilization and pollen limitation
Polyploidy is widespread in plants, yet the establishment of neo-polyploids is limited by minority cytotype exclusion (MCE). As polyploidy has been associated with higher selfing rates in empirical st...
www.biorxiv.org
October 31, 2025 at 8:17 AM
Reposted by Nicolas Bierne
🧪🌎 We have a conceptually similar method, RDAforest, just published with @kristinaleilani.bsky.social - only it is about predicting genetic adaptation across unsampled landscape doi.org/10.1111/1755...
October 24, 2025 at 11:20 AM
Reposted by Nicolas Bierne
Proud of the latest edition of my free intro biostats book.

gitrepo: github.com/ybrandvain/b...
book: ybrandvain.github.io/biostats/

Not complete but at a good point to take a break, and I think its quite usable

dm me with comments , ideas etc
Applied Biostatistics
ybrandvain.github.io
October 24, 2025 at 2:33 PM
Reposted by Nicolas Bierne
Hey Yaniv Brandvain is not on Bluesky but his most recent biostats ebook is live ybrandvain.github.io/biostats/. His stats resources have been so helpful to me as I develop my own stats course, so check it out. Github repo here: github.com/ybrandvain/b...
Applied Biostatistics
ybrandvain.github.io
October 24, 2025 at 2:47 PM
Reposted by Nicolas Bierne
Microchimerism is one of the most fascinating biological phenomena I've ever studied. But what do we actually know & what do we not know? Our new paper brings together microchimerism researchers to ask the key questions driving the field forward 🧬

advanced.onlinelibrary.wiley.com/doi/10.1002/...
October 24, 2025 at 5:08 PM
Reposted by Nicolas Bierne
🌊 Mytilus galloprovincialis meets Eco-Evo-Devo. We’re excited to announce the first school dedicated to the bivalve M. galloprovincialis. Applications are now open!✨🐚
Get ready to explore the fascinating world of mussels in an inspiring international environment 🔬
ℹ️ acrobat.adobe.com/id/urn:aaid:...
September 25, 2025 at 1:05 PM
Reposted by Nicolas Bierne
Second day at the Speciation Jacques Monod conference #cjm25, it goes so fast, amazing talks about the biogeography of speciation and hybridization
October 22, 2025 at 8:20 PM
Reposted by Nicolas Bierne
What a nice start to the Jacques Monod conference #cjm25 on speciation in Roscoff, Britany. What an inspiring lineup of talks and scientists. Even the weather is remarkably welcoming, for now, at least. 🤩
October 21, 2025 at 7:47 PM
Reposted by Nicolas Bierne
What a nice start and amazing first day of Jacques Monod conference on bridging the micro macroevolution gap #cjm25 plenty of fascinating talks and posters

Didn't react quickly enough to illustrate all of them, just catch a few
October 21, 2025 at 8:45 PM
Good morning Roscoff #cjm25
October 21, 2025 at 6:30 AM
Just took my breakfast at the #cjm25 speciation conference and around me in a 50m2 breakfast room were seated Nick Barton, Craig Moritz, Amaury Lambert, Maud tenaillon, Ludovic Orlando, Stuart Baird, John Welch, Daniel Matute etc... This density of 🤯🤯🤯 !
October 21, 2025 at 6:01 AM
Arrived at Roscoff in Brittany for the conference Jacques Monod on #speciation. What a view ! Do we have a hashtag? #cjm25? First plenary lecture was tonight on our (in)hability to predict diversification rates from microevolutionary processes.
October 20, 2025 at 8:43 PM
Reposted by Nicolas Bierne
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM
Reposted by Nicolas Bierne
Cross-species cloning in ants 🐜
These two males belong to different species—but share the same mother. How? Why?
To celebrate the print release of our last paper in this week’s @nature.com (issue 8084), here’s a thread summarizing the results. Why? Let’s dive in🧵👇 www.nature.com/articles/s41...
October 14, 2025 at 12:00 PM
Wow 🤩 new bivalve transmissible cancer #TransCan study by the amazing @metzgerm.bsky.social lab on the progression of the disease over long periods. Progression to death, long-term non-progression and remission quantified. Looking forward comparing with our results in #MusselsAreCool MtrBTN #MarEvol
I am happy to share some good news from the lab! Our paper on the outcomes of Bivalve Transmissible Neoplasia is out this week in PLOS Pathogens!
doi.org/10.1371/jour...
October 13, 2025 at 12:09 PM
Reposted by Nicolas Bierne
I am happy to share some good news from the lab! Our paper on the outcomes of Bivalve Transmissible Neoplasia is out this week in PLOS Pathogens!
doi.org/10.1371/jour...
October 9, 2025 at 7:33 PM
Scanning mussel morphology #MusselsAreCool. The attempts are not yet conclusive, but it's cool.
October 7, 2025 at 1:13 PM
Reposted by Nicolas Bierne
October 1, 2025 at 7:12 PM
Reposted by Nicolas Bierne
On vous attend à Courbevoie le 11 octobre ! Un conte scientifique et musical de 7 à 97 ans 😀
...entre arts, cinéma, science, tables rondes et échanges avec le public. Evènement gratuit
Avec la contribution de Marc-André Selosse, professeur et parrain du festival & @pierenry.bsky.social professeur émérité @isyeb.mnhn.fr
➡️ 🌱 www.atmospheresfestival.com
Festival Atmosphères | 8 au 12 octobre 2025 | À Courbevoie et en ligne
La 15e édition du Festival Atmosphères propose une programmation pluridisciplinaire à travers le cinéma, l'art, la science - Gratuit.
www.atmospheresfestival.com
September 29, 2025 at 10:11 AM
Reposted by Nicolas Bierne
Exciting news!
The next #PopGroup meeting will take place in Lille 🍟, France, 7–9 January 2026 – just 1 hour by train from London, Brussels, and Paris.

This year, PopGroup will also host ALPHY, the annual meeting of Evolutionary Genomics.

More info: populationgeneticsgroup.org.uk

See you there !
Population Genetics group 59
populationgeneticsgroup.org.uk
September 29, 2025 at 8:52 AM
Reposted by Nicolas Bierne
Very happy to announce that the next POPGROUP meeting will take place in Lille on 7-9 January !

Follow ‪@popgroup2026.bsky.social for all updates.

📢 Please share widely ! 📢‬
Exciting news!
The next #PopGroup meeting will take place in Lille 🍟, France, 7–9 January 2026 – just 1 hour by train from London, Brussels, and Paris.

This year, PopGroup will also host ALPHY, the annual meeting of Evolutionary Genomics.

More info: populationgeneticsgroup.org.uk

See you there !
Population Genetics group 59
populationgeneticsgroup.org.uk
September 29, 2025 at 1:06 PM