Carsten Korth
@ckorth.bsky.social
Head of Molecular Psychiatry and Neurodegeneration Laboratory at Heinrich Heine University of Düsseldorf, Germany. Transmission and co-evolution mechanisms for brain function from the molecular to the individual/organismal level.
Pinned
Carsten Korth
@ckorth.bsky.social
· Apr 28
Tool evolution as a prerequisite of consciousness
"consciousness could not have evolved without prior extensive cumulative cultural evolution executed by social transmission, and the extended mind leading to tool evolution and social synchronization"
www.degruyterbrill.com/document/doi...
"consciousness could not have evolved without prior extensive cumulative cultural evolution executed by social transmission, and the extended mind leading to tool evolution and social synchronization"
www.degruyterbrill.com/document/doi...
"we present an in situ proteome analysis of age-associated human brain lipofuscin that ... reveals PPT1 protein as one major constituent ...It remains to be demonstrated whether PPT1's ... sequestration to lipofuscin leads to ... functional impairments"
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
<em>Neuropathology and Applied Neurobiology</em> | BNS Journal | Wiley Online Library
Proteomics of laser-dissected lipofuscin from aged, healthy brains reveals Palmitoyl-Protein Thioesterase 1 (PPT1) and other CLN proteins as constituents.
PPT1 is increasingly sequestered to lipo...
onlinelibrary.wiley.com
November 9, 2025 at 3:11 PM
"we present an in situ proteome analysis of age-associated human brain lipofuscin that ... reveals PPT1 protein as one major constituent ...It remains to be demonstrated whether PPT1's ... sequestration to lipofuscin leads to ... functional impairments"
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Carsten Korth
@sfnjournals.bsky.social , @hhu.de , @ckorth.bsky.social , @socforneuroecon.bsky.social , @sfn.org , @decisionneurop.bsky.social
#neuroscience #schizophrenia #sociallearning #social #socialneuroscience #neuroeconomics
doi.org/10.1523/JNEU...
#neuroscience #schizophrenia #sociallearning #social #socialneuroscience #neuroeconomics
doi.org/10.1523/JNEU...
Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1)
Social deficits are a hallmark of schizophrenia, often characterized by impairments in processing and integrating socially transmitted information. However, translational models that accurately captur...
doi.org
October 30, 2025 at 11:27 AM
Reposted by Carsten Korth
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
September 25, 2025 at 11:17 AM
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
September 25, 2025 at 11:17 AM
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human hippocampus lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human hippocampus lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
September 24, 2025 at 3:42 PM
Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human hippocampus lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human hippocampus lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...
Disruption to the gut microbiome by non-antibiotics is linked to infection risk: Cell Chemical Biology www.cell.com/cell-chemica...
Disruption to the gut microbiome by non-antibiotics is linked to infection risk
Human-targeted drugs alter the composition and function of the gut microbiome, but
their effect on the risk of gastrointestinal infection has received little attention.
In two studies, Grieβhammer et ...
www.cell.com
September 23, 2025 at 11:57 AM
Disruption to the gut microbiome by non-antibiotics is linked to infection risk: Cell Chemical Biology www.cell.com/cell-chemica...
JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease insight.jci.org/articles/vie...
JCI Insight -
Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease
insight.jci.org
September 20, 2025 at 2:34 PM
JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease insight.jci.org/articles/vie...
Reposted by Carsten Korth
our paper is out:
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-In-Schizophrenia 1 (DISC1)
Social deficits are a hallmark of schizophrenia, often characterized by impairments in processing and integrating socially transmitted information. However, translational models that accurately captur...
www.jneurosci.org
September 12, 2025 at 10:31 AM
our paper is out:
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
our paper is out:
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-In-Schizophrenia 1 (DISC1)
Social deficits are a hallmark of schizophrenia, often characterized by impairments in processing and integrating socially transmitted information. However, translational models that accurately captur...
www.jneurosci.org
September 12, 2025 at 10:31 AM
our paper is out:
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."
www.jneurosci.org/content/earl...
Proximity to Golf Courses and Risk of Parkinson Disease
url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=090525
url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=090525
September 5, 2025 at 2:11 PM
Proximity to Golf Courses and Risk of Parkinson Disease
url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=090525
url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833716?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=090525
Our results are consistent with previous studies and provide clues regarding the contribution of viruses to the pathology of psychiatric disorders.""
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology - Translational Psychiatry
Translational Psychiatry - Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology
www.nature.com
July 21, 2025 at 11:52 AM
Our results are consistent with previous studies and provide clues regarding the contribution of viruses to the pathology of psychiatric disorders.""
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Carsten Korth
Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
Frontiers | Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness
IntroductionConsciousness relies on both cortical and subcortical structures and their feedforward and feedback pathways. Within this framework, the thalamus...
www.frontiersin.org
July 21, 2025 at 5:03 AM
Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness
www.frontiersin.org/journals/neu...
www.frontiersin.org/journals/neu...
"Sleep, like ageing17,18, may be an inescapable consequence of aerobic metabolism"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
July 19, 2025 at 9:30 PM
"Sleep, like ageing17,18, may be an inescapable consequence of aerobic metabolism"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids | Science Advances www.science.org/doi/10.1126/...
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids
SARS-CoV-2 induces amyloid-β pathology in the central nervous system.
www.science.org
July 16, 2025 at 2:50 PM
SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids | Science Advances www.science.org/doi/10.1126/...
„Research Trek – Aufbruch in ein unbekanntes Wissenschaftssystem“ dirnagl.com/2025/06/17/r...
„Research Trek – Aufbruch in ein unbekanntes Wissenschaftssystem“
Für die Beitragsserie „Forschung vordenken für 2035“ in den table.briefings research skizzierte ich meine Vision für die wissenschaftspolitische Welt der Zukunft in Form der fiktiven TV-Serie „Rese…
dirnagl.com
July 16, 2025 at 2:43 PM
„Research Trek – Aufbruch in ein unbekanntes Wissenschaftssystem“ dirnagl.com/2025/06/17/r...
"We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent."
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Psilocybin treatment extends cellular lifespan and improves survival of aged mice - npj Aging
npj Aging - Psilocybin treatment extends cellular lifespan and improves survival of aged mice
www.nature.com
July 9, 2025 at 12:12 PM
"We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent."
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Please visit my poster July 9th 4:30 pm at the upcoming @assc28.bsky.social :
"Content consciousness as an acquired cognition
entangled with tool evolution" basically. presenting my recent paper "Tool evolution as a prerequisite for consciousness" shorturl.at/ATzwD -looking forward for discussions!
"Content consciousness as an acquired cognition
entangled with tool evolution" basically. presenting my recent paper "Tool evolution as a prerequisite for consciousness" shorturl.at/ATzwD -looking forward for discussions!
Tool evolution as a prerequisite for consciousness
Within the concept of the extended mind, the active modification of external objects, externalizations, is seen as an auxiliary means to adapt to the environment. Toolmaking and use are advanced stage...
shorturl.at
July 1, 2025 at 2:12 PM
Please visit my poster July 9th 4:30 pm at the upcoming @assc28.bsky.social :
"Content consciousness as an acquired cognition
entangled with tool evolution" basically. presenting my recent paper "Tool evolution as a prerequisite for consciousness" shorturl.at/ATzwD -looking forward for discussions!
"Content consciousness as an acquired cognition
entangled with tool evolution" basically. presenting my recent paper "Tool evolution as a prerequisite for consciousness" shorturl.at/ATzwD -looking forward for discussions!
Event structure sculpts neural population dynamics in the lateral entorhinal cortex | Science www.science.org/doi/10.1126/...
Event structure sculpts neural population dynamics in the lateral entorhinal cortex
Our experience of the world is a continuous stream of events that must be segmented and organized at multiple timescales. The neural mechanisms underlying this process remain unknown. In this work, we...
www.science.org
June 28, 2025 at 7:02 AM
Event structure sculpts neural population dynamics in the lateral entorhinal cortex | Science www.science.org/doi/10.1126/...
