Chris van der Gast
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chrisvandergast.bsky.social
Chris van der Gast
@chrisvandergast.bsky.social
Professor of Microbiome Ecology. Gut & Lung Microbiomes in Cystic Fibrosis. #Firstgen

https://www.northumbria.ac.uk/about-us/our-staff/v/chris-van-der-gast/
Our new paper out on influence of chronic pancreatitis on the gut microbiome. What makes this more special is it is Ryan Marsh’s 1st as corresponding author.

doi.org/10.1186/s128...
Investigating microbiota differences across chronic pancreatitis, influenced by lifestyle and genetic determinants - BMC Gastroenterology
Chronic pancreatitis (CP) is a multifaceted and irreversible inflammatory condition that impacts both endocrine and exocrine pancreatic functions. Whilst there is evidence of a general intestinal micr...
doi.org
October 21, 2025 at 2:50 PM
Got an invite to review a paper on Friday night from a well-known clinical journal. Followed by an abrupt & demanding reminder early Sunday morning

I wonder why it is increasingly difficult to get willing quality reviewers these days?🤷‍♂️

Unsurprisingly I declined the offer to review
October 13, 2025 at 8:20 AM
Great to be in Queen's Univerity Belfast for the GRAMPUS-CF conference

This @cysticfibrosis.org.uk funded Strategic Research Centre is exploring ‘clusters’ of gut symptoms in #CysticFibrosis to see if they have common causes

More details on GRAMPUS #CF ⬇️ www.grampus-cf.org
GRAMPUS-CF | Discover Gut Insights Today
Join the GRAMPUS-CF study to explore gut symptoms in cystic fibrosis and help develop personalized treatments. Enroll online or via CF centers.
www.grampus-cf.org
September 16, 2025 at 8:56 AM
Our new paper out in Microbiology Spectrum:

Nontuberculous mycobacteria remodel lung microbiota in #cysticfibrosis associated respiratory infections

Driven by @dwrivett.bsky.social and Michelle Hardman.

From Michelle’s @cysticfibrosis.org.uk funded PhD work

#CF

doi.org/10.1128/spec...
Nontuberculous mycobacteria remodel lung microbiota in cystic fibrosis-associated respiratory infections | Microbiology Spectrum
The influence of NTM infection in pwCF is still debated, and the extent of their contribution to mortality and morbidity is still questioned. Findings in this study highlight a link between the presen...
doi.org
August 1, 2025 at 8:03 AM
Our new paper out now in Microbiome: Species turnover within #cysticfibrosis lung microbiota is indicative of acute pulmonary exacerbation onset

doi.org/10.1186/s401...

#CF #microbiomeecology #microbiome
Species turnover within cystic fibrosis lung microbiota is indicative of acute pulmonary exacerbation onset - Microbiome
Background Acute pulmonary exacerbations (PEx) are associated with increased morbidity and earlier mortality for people living with cystic fibrosis (pwCF). The most common causes of PEx in CF are by b...
doi.org
June 7, 2025 at 10:37 AM
Our very own @hgavillet.bsky.social giving her talk today at #ECFS2025 in Milan on the impact of #kaftrio CFTR modulator therapy on the #CysticFibrosis lung microbiome

Our KAFPATH-CF study is a multi-national (UK, USA, & Canada) multi-centre long-term longitudinal study of adults with #CF
June 5, 2025 at 8:48 PM
Our very own Ryan Marsh presenting his #CysticFibrosis gut microbiome & metabolomics data at the #ECFS2025 meeting in Milan

This is part of the wider @cysticfibrosis.org.uk funded GRAMPUS-CF strategic research centre

👀 here for more details www.grampus-cf.org
June 5, 2025 at 8:42 PM
Fascinating and important study. May well be transformative in treatment of stubborn chronic lung infections such as by Pseudomonas aeruginosa in #cysticfibrosis and beyond

rdcu.be/ekdWf
Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis
Nature Medicine - A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of...
rdcu.be
May 1, 2025 at 9:15 AM
Ryan Marsh from my group giving a great talk on our initial #CysticFibrosis gut microbiome findings from our GRAMPUS-CF strategic research centre @ the #ECFS Basic Science meeting in Italy
March 29, 2025 at 2:02 PM
Final day of the European Young Investigators Meeting #EYIM for #cysticfibrosis in Paris

Delighted to be supporting as a ‘senior’ scientist

The #EYIM2025 presentations have been outstanding

The talent displayed at this meeting bodes well for future of #CF research
February 28, 2025 at 11:10 AM
Helen giving her Rising Star talk @ the #RTI2025 meeting in Glasgow ⭐️

@hgavillet.bsky.social #CF #CysticFibrosis
February 4, 2025 at 1:24 PM
What a a great place to meet & talk on new #cysticfibrosis respiratory & gut studies with the lovely folk from Manchester Paediatric #CF centre

Feeling genuinely inspired

Whitworth Art Gallery - Manchester
January 16, 2025 at 3:25 PM
Helen a PDRA in my lab @northumbriauni.bsky.social has been recognised with the Rising Star award @ the upcoming Respiratory Infections Forum #RTI2025.

Well done Helen, what a great recognition!

rti-forum.org/2025/
@lenagroup4resp.bsky.social
January 10, 2025 at 8:20 AM
Ah, the glamour of international travel. This red eye flight is so early I had to get up half an hour before I went to bed.
December 14, 2024 at 5:02 AM
Microbiome ecology approaches reveal bacterial interactions underpin worse lung function in #CysticFibrosis

#CF Lung infections are not caused by 1 pathogen in isolation but instead by interplay of complex lung microbiota of many different microbes interacting with each other & the lung environment
November 25, 2024 at 10:27 AM
Fantastic to see our latest paper now published in mBio on how species interactions impact #cysticfibrosis respiratory infections ⤵️

#microbiomeecology #cf

Lovely way to finish the week

doi.org/10.1128/mbio...
Bacterial interactions underpin worsening lung function in cystic fibrosis-associated infections | mBio
Research studies have repeatedly demonstrated that chronic lung infection in cystic fibrosis is polymicrobial and consequently does not adhere to the single microbe-based Koch’s postulates. Despite th...
doi.org
November 22, 2024 at 3:08 PM
Reposted by Chris van der Gast
After editing, this very short letter to New Scientist is even shorter now. But I think it gets the point across! @faecalmatters.bsky.social
November 11, 2024 at 10:23 PM
Our latest paper now published in Journal of #cysticfibrosis

Impact of extended Kaftrio therapy on the gut #microbiome in #cf

Great work from Ryan Marsh (not yet in this place)

sciencedirect.com/science/arti...
Impact of extended Elexacaftor/Tezacaftor/Ivacaftor therapy on the gut microbiome in cystic fibrosis
There is a paucity of knowledge on the longer-term effects of CF transmembrane conductance regulator (CFTR) modulator therapies upon the gut microbiom…
sciencedirect.com
November 13, 2024 at 3:19 PM