Chris Thomas
@chrismthomas.bsky.social
Professor at University of Birmingham. Passionate about plasmids: how they work; how to use them; how to displace them when they are a nuisance. Founded International Society for Plasmid Biology (ISPB) in 2004. Currently Treasurer of ISPB and FEMS
After discussion with some current students at the University of Birmingham I sent them a link to a YouTube video some of my students (Carys Ladd, Sanem Sertug and Yuqian Ye) made about our work a few years ago so I thought I would share the link: www.youtube.com/watch?v=yH8A...
November 3, 2025 at 12:37 PM
After discussion with some current students at the University of Birmingham I sent them a link to a YouTube video some of my students (Carys Ladd, Sanem Sertug and Yuqian Ye) made about our work a few years ago so I thought I would share the link: www.youtube.com/watch?v=yH8A...
Reposted by Chris Thomas
Chris Thomas
Our commercialisation arm, University of Birmingham Enterprise Ltd, issued a press release last week (bit.ly/3SBfuLq) related to our recent Nucleic Acids Research paper (bit.ly/4lSyCSH ) and other on-going work.
Our commercialisation arm, University of Birmingham Enterprise Ltd, issued a press release last week (bit.ly/3SBfuLq) related to our recent Nucleic Acids Research paper (bit.ly/4lSyCSH ) and other on-going work.
Research advances on ‘displacing’ antibiotic resistance gene from bacteria - University of Birmingham
The research is on plasmids, small, circular strands of DNA, that allow bacteria to share genes rapidly, and carry genes conferring antibiotic resistance.
bit.ly
May 12, 2025 at 10:14 AM
Chris Thomas
Our commercialisation arm, University of Birmingham Enterprise Ltd, issued a press release last week (bit.ly/3SBfuLq) related to our recent Nucleic Acids Research paper (bit.ly/4lSyCSH ) and other on-going work.
Our commercialisation arm, University of Birmingham Enterprise Ltd, issued a press release last week (bit.ly/3SBfuLq) related to our recent Nucleic Acids Research paper (bit.ly/4lSyCSH ) and other on-going work.
Reposted by Chris Thomas
The paper is now live: academic.oup.com/mbe/article/...
Absolutely delighted to play a role in this fascinating story!
Absolutely delighted to play a role in this fascinating story!
April 17, 2025 at 9:57 AM
The paper is now live: academic.oup.com/mbe/article/...
Absolutely delighted to play a role in this fascinating story!
Absolutely delighted to play a role in this fascinating story!
This week's highlight was the 2nd ISPB Virtual Seminar 2025 (www.plasmidbiologysociety.org/ispb-virtual...) organised by Manuel Ares Arroyo, Fabienne Benz and Pedro Dorado Morales (Inst Pasteur) Great talks by Maho Tokuda and Celia Souque. You can still sign up if you have not already done so.
ISPB Virtual Seminar Series 2025 | International Society for Plasmid Biology
www.plasmidbiologysociety.org
April 17, 2025 at 8:03 AM
This week's highlight was the 2nd ISPB Virtual Seminar 2025 (www.plasmidbiologysociety.org/ispb-virtual...) organised by Manuel Ares Arroyo, Fabienne Benz and Pedro Dorado Morales (Inst Pasteur) Great talks by Maho Tokuda and Celia Souque. You can still sign up if you have not already done so.
Reposted by Chris Thomas
The study on the FIB replicon of plasmid F that I talked about at Plasmid Biology 2022 in Toulouse is eventually published in Nucleic Acids Research: academic.oup.com/nar/article-...
Activation, incompatibility, and displacement of FIB replicons in E. coli
Abstract. Multi-replicon sex-factor F is the archetype of the largest plasmid group in clinical Enterobacteriaceae. Such plasmids spread antimicrobial resi
academic.oup.com
April 11, 2025 at 8:45 AM
The study on the FIB replicon of plasmid F that I talked about at Plasmid Biology 2022 in Toulouse is eventually published in Nucleic Acids Research: academic.oup.com/nar/article-...
At what stage will someone decide that NCBI should not be a worldwide resource?
A friend at NIH received notice that the National Library of Medicine is terminating its bioinformatics program
April 5, 2025 at 8:44 AM
At what stage will someone decide that NCBI should not be a worldwide resource?
The second great paper concerns the discovery in Eva Top's group that an enigmatic protein encoded by IncP-1beta plasmids modulates the IncP-1 circuitry in E. coli to make the plasmid a burden in this host: Elg et al recently accepted in Molecular Biology and Evolution doi.org/10.1093/molb...
pendingpublications
Pending Publication
doi.org
April 4, 2025 at 8:51 AM
The second great paper concerns the discovery in Eva Top's group that an enigmatic protein encoded by IncP-1beta plasmids modulates the IncP-1 circuitry in E. coli to make the plasmid a burden in this host: Elg et al recently accepted in Molecular Biology and Evolution doi.org/10.1093/molb...
It is a privilege to be an author on two great plasmid papers already this year. The first was McLean et al in Nature Microbiology focused on KorB and the discovery that it is a CTPase by Yung Le's group at the John Innes Institute in Norwich. www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
April 4, 2025 at 8:43 AM
It is a privilege to be an author on two great plasmid papers already this year. The first was McLean et al in Nature Microbiology focused on KorB and the discovery that it is a CTPase by Yung Le's group at the John Innes Institute in Norwich. www.nature.com/articles/s41...