Carolin Klose
@carolinklose.bsky.social
PhD student at TUM& MPIB
with Matthias Feige and Brenda Schulman
Proteostasis and membrane protein enthusiast
Boehringer Ingelheim Fonds PhD fellow
with Matthias Feige and Brenda Schulman
Proteostasis and membrane protein enthusiast
Boehringer Ingelheim Fonds PhD fellow
Super excited to share our new #preprint on #BioRxiv ✨
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...
Structural basis of an EMC:Spf1 insertase-dislocase complex in the eukaryotic endoplasmic reticulum
Most eukaryotic membrane proteins are inserted into the membrane at the endoplasmic reticulum (ER). This essential but error-prone process relies on molecular quality control machineries to prevent mi...
www.biorxiv.org
August 11, 2025 at 12:35 PM
Super excited to share our new #preprint on #BioRxiv ✨
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...
We reveal the structural basis of a partnership between the ER membrane complex (EMC) and the P5A-ATPase Spf1 — an insertase–dislocase duo that coordinates membrane protein biogenesis and quality control.
www.biorxiv.org/content/10.1...
Excited to share our latest study in @natcomms.nature.com , where we characterize the chaperone function of the ER membrane protein complex (EMC)—supporting membrane protein biogenesis beyond insertion!
1/9
www.nature.com/articles/s41...
1/9
www.nature.com/articles/s41...
The EMC acts as a chaperone for membrane proteins - Nature Communications
Membrane proteins are essential for any cell but difficult to fold. Here, the authors show that the EMC acts as a chaperone for membrane proteins. They dissect client recognition and provide a molecul...
www.nature.com
August 5, 2025 at 1:18 PM
Excited to share our latest study in @natcomms.nature.com , where we characterize the chaperone function of the ER membrane protein complex (EMC)—supporting membrane protein biogenesis beyond insertion!
1/9
www.nature.com/articles/s41...
1/9
www.nature.com/articles/s41...