Brain and Sleep Research Laboratory
@bsrlaboratory.bsky.social
The Brain and Sleep Research Laboratory is a joint effort of Luisa de Vivo and Michele Bellesi to investigate the neurobiology of sleep and wakefulness
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep - Nature Communications
Using simultaneous EEG-PET-MRI, this study reveals tightly coupled physiological dynamics during the descent from wakefulness into NREM sleep and identifies network-specific activity underlying sensor...
www.nature.com
October 25, 2025 at 7:47 AM
Simultaneous EEG-PET-MRI identifies temporally coupled and spatially structured brain dynamics across wakefulness and NREM sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial El...
www.medrxiv.org
August 20, 2025 at 9:41 AM
Enhancement of Sleep Slow Wave Activity using Transcranial Electrical Stimulation with Temporal Interference
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Brain and Sleep Research Laboratory
💤🧠🧪 New article! 🧪🧠💤
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
August 14, 2025 at 1:40 PM
💤🧠🧪 New article! 🧪🧠💤
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
After years of effort led by @qualiastructure.bsky.social (Nao Tsuchiya and William Wong), Jenny Windt, Katja Valli, Valdas Noreika and @rherzoga.bsky.social, the Dream database is now published in @natcomms.nature.com
**A dream EEG and mentation database**
rdcu.be/eAwni
Mitochondrial origins of the pressure to sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mitochondrial origins of the pressure to sleep - Nature
Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
www.nature.com
July 17, 2025 at 2:00 PM
Mitochondrial origins of the pressure to sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neuroendocrine circuit for sleep-dependent growth hormone release: Cell www.cell.com/cell/fulltex...
Neuroendocrine circuit for sleep-dependent growth hormone release
The increase in growth hormone release during sleep is driven by sleep-wake-dependent
activity of stimulatory GHRH neurons and inhibitory SST neurons in the hypothalamus.
The released growth hormone e...
www.cell.com
June 25, 2025 at 1:41 PM
Neuroendocrine circuit for sleep-dependent growth hormone release: Cell www.cell.com/cell/fulltex...
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation
Sleep is crucial for memory formation. Deng et al. find that cAMP levels in mice oscillate
with a 1-min cycle during slow-wave sleep, and hippocampal activity at the peak of
these oscillations is nece...
www.cell.com
June 18, 2025 at 7:52 PM
A time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...
Increased CSF drainage by non-invasive manipulation of cervical lymphatics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature
The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.
www.nature.com
June 6, 2025 at 6:31 PM
Increased CSF drainage by non-invasive manipulation of cervical lymphatics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The great brain clearance and dementia debate
www.nature.com/articles/d41...
www.nature.com/articles/d41...
The great brain clearance and dementia debate
An established theory for how good sleep reduces a person’s risk of neurodegenerative disease has been called into question. The ensuing argument could have enormous consequences for the treatment of ...
www.nature.com
May 6, 2025 at 6:52 PM
The great brain clearance and dementia debate
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep - Nature Communications
Neural mechanisms underlying memory acquisition and encoding are not fully understood. Here authors show that during sleep, besides the replay of past memory, coactivity of a new set of cells arises (...
www.nature.com
April 29, 2025 at 4:49 PM
Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate
fluctuations are a biomarker of sleep/wake transitions, where in...
www.pnas.org
March 27, 2025 at 8:11 PM
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reversible reduction in brain myelin content upon marathon running
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reversible reduction in brain myelin content upon marathon running - Nature Metabolism
Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise,...
www.nature.com
March 25, 2025 at 7:51 PM
Reversible reduction in brain myelin content upon marathon running
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Enhanced memory despite severe sleep loss in Drosophila insomniac mutants
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Enhanced memory despite severe sleep loss in Drosophila insomniac mutants
Sleep is known to support memory. In this study, the authors identify an instance where memory hyperfunction may actually provoke sleep deficits. They find that the short-sleep Drosophila mutants, ins...
journals.plos.org
March 22, 2025 at 2:32 PM
Enhanced memory despite severe sleep loss in Drosophila insomniac mutants
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...
www.nature.com
March 21, 2025 at 3:52 PM
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pupil size reveals arousal level fluctuations in human sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Pupil size reveals arousal level fluctuations in human sleep - Nature Communications
Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...
www.nature.com
March 1, 2025 at 1:37 PM
Pupil size reveals arousal level fluctuations in human sleep
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life | PNAS
In wearable smart systems, continuous monitoring and accurate classification of different
sleep-related conditions are critical for enhancing sleep...
www.pnas.org
February 18, 2025 at 8:25 PM
A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Brain and Sleep Research Laboratory
Our latest in PNAS! 🎉
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep | PNAS
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate
fluctuations are a biomarker of sleep/wake transitions, where in...
www.pnas.org
February 18, 2025 at 7:48 PM
Our latest in PNAS! 🎉
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep
Take home message?
KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.
www.pnas.org/doi/10.1073/...
Amygdalo-cortical dialogue underlies memory enhancement by emotional association: Neuron www.cell.com/neuron/fullt...
Amygdalo-cortical dialogue underlies memory enhancement by emotional association
How does emotion prioritize associated memory? Saito et al. show that emotional association
enhances perceptual memory retention and amygdalo-cortical coordination during learning
and early-NREM sleep...
www.cell.com
February 18, 2025 at 3:26 PM
Amygdalo-cortical dialogue underlies memory enhancement by emotional association: Neuron www.cell.com/neuron/fullt...
Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model: iScience www.cell.com/iscience/ful...
Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
decline, beta-amyloid plaques, and tau tangles. Growing evidence suggests a strong
link between sleep disturbances a...
www.cell.com
February 16, 2025 at 9:49 AM
Rocking during sleep reduces motor deficits and beta-amyloid levels in an Alzheimer’s mouse model: iScience www.cell.com/iscience/ful...
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice - Nature Metabolism
Scott, Tan et al. characterize the neural circuits that link mechanic stimuli in the heart and gut with whole-body energy homeostasis and vigilance.
www.nature.com
January 22, 2025 at 4:25 PM
Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mice
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic remo…
www.sciencedirect.com
January 9, 2025 at 3:09 PM
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
