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beatolab.bsky.social
BeatoLab
@beatolab.bsky.social
Neuroscience, control of movement, motoneuron physiology and all that is spinal cord related
An absolutely lovely paper, if I may say so... Joint effort from @tuanbuilab.bsky.social, Turgay Akay, and the Beatostone lab, aka Rob Brownstone's lab and mine
Do comparator modules exist within spinal circuits? Here, we show that spinal dI3 neurons integrate multimodal sensory feedback, receive direct efference copy from Renshaw cells, and mediate corrections of ongoing movements. Thank you so much to everyone involved!!
www.biorxiv.org/content/10.1...
Evidence of spinal cord comparator modules for rapid corrections of movements
Successful movement requires continuous adjustments in response to changes in internal and external environments. To do so, neural circuits continuously compare efference copies of motor commands with sensory input to respond to sensory prediction errors. Some responses need to be very fast and, for limbs, likely occur in as yet undefined spinal cord circuits. Here, we describe spinal circuits involving dI3 neurons, showing that they receive multimodal sensory inputs and direct efferent copies from both Renshaw cells and motor neurons. We further show that they form connections to motor pools, including diverging connections to antagonist motor nuclei. Reducing dI3 neuronal activity diminished stumbling responses, as did disrupting Renshaw cell circuits, providing evidence for a comparator role of dI3 neurons for online corrections. Together, our findings reveal a pivotal role for dI3 neurons functioning as comparators of internal predictions and external sensory feedback to mediate rapid corrections of ongoing movements. ### Competing Interest Statement Robert M. Brownstone is a co-founder and director of Sania Therapeutics Inc. Wellcome Trust, https://ror.org/029chgv08, 221610/Z/20/Z, 227433/Z/23/Z, 225674/Z/22/Z Royal Society, NIF\R1\192316 Canadian Institutes of Health Research, https://ror.org/01gavpb45, PJT 180556, PJT 162357 Biotechnology and Biological Sciences Research Council, BB/S005943/1
www.biorxiv.org
September 2, 2025 at 7:32 PM
Reposted by BeatoLab
🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here:
www.nature.com/naturecareer...
Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324
About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out
www.nature.com
June 19, 2025 at 12:59 PM
Looking forward to imposing it to everyone in my lab!
A British @ianduguid.bsky.social, a French @nwanaverbecq.bsky.social and an Italian @scimemia.bsky.social are stranded on a desert island...what do they do? They work on an ephys textbook! www.worldscientific.com/worldscibook...
May 9, 2025 at 4:27 PM
Reposted by BeatoLab
New preprint out! We developed a behavioural platform for the kinematic analysis of skilled whole body behaviour. Very fun collaboration with Christopher Black, @liamebrowne.bsky.social and Rob Brownstone.
Ethologically relevant behavioural assay for investigating reach and grasp kinematics during whole-body motor control in mice https://www.biorxiv.org/content/10.1101/2025.04.04.647225v1
April 6, 2025 at 1:59 PM
Congratulations Boris and Brandon!
🥇 The €200K Institutional Award goes to @pubpeer.com, a community platform for rapid post-publication peer review to improve scientific publications. 19% of global retractions have been the subject of prior discussions on PubPeer since its launch in 2012. Congratulations! 🥳
March 15, 2025 at 9:18 AM
Reposted by BeatoLab
Come join our lab as Postdoctoral Fellow! The project will investigate the maturation of spinal circuits and their plasticity within chronic widespread pain states.
Apply here: www.ucl.ac.uk/work-at-ucl/... until 11th April.
@ucllifesciences.bsky.social @uclnpp.bsky.social @jobrxiv.bsky.social
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
www.ucl.ac.uk
March 14, 2025 at 12:47 PM
Looking around me, I may see one or two examples of bullshit jobs ...
March 7, 2025 at 7:28 AM
Exceptional paper, congratulations to Jay and all his team. A brain-wide map of descending inputs onto spinal V1 interneurons: Neuron www.cell.com/neuron/fullt....
A brain-wide map of descending inputs onto spinal V1 interneurons
Chapman et al. generate a brain-wide atlas of supraspinal inputs to cervical V1 interneurons. Monosynaptic input arises from over two dozen brain regions, some of which preferentially innervate molecu...
www.cell.com
February 20, 2025 at 8:34 PM
Reposted by BeatoLab
🥁 Elisa Toscano idenitified a new subtype of propriospinal neurons and found a role in the execution of skilled movements🤸‍♂️. Great job from Elisa and everybody involved 💪. @alesantuz.bsky.social, @lowensteined.bsky.social. Check it out and let us know what you think:
www.biorxiv.org/content/10.1...
Identification of V0g propriospinal neurons and their role in locomotor control
Propriospinal neurons relay sensory and motor information across the spinal cord and are critical components of the circuits coordinating body movements. Their diversity and roles in motor control are...
www.biorxiv.org
February 14, 2025 at 10:33 AM
Reposted by BeatoLab
📆 From detection to prevention: improving the scientific publication record - Join the 2024 Einstein Foundation Award Winners’ Colloquium w/ @elisabethbik.bsky.social, @brandonstell.bsky.social @pubpeer.com, @helenajambor.bsky.social & Christopher Schmied
www.einsteinfoundation.de/en/insights/...
February 13, 2025 at 9:12 AM
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RA positions with potential PhD continuation are now open! We're seeking two candidates with slice patch clamp or programming skills for the projects outlined in the advert: www.jobs.cam.ac.uk/job/50040/
Apply by 21 February!
📣 Opportunity Alert! We have two PhD positions in our lab at Cambridge University starting in Autumn 2025. Exceptional candidates may join earlier as RAs and receive PhD funding if scholarship applications are unsuccessful (RA advert coming soon!).
Details here: www.keshavarzilab.com/blog/phd-pos...
January 26, 2025 at 1:37 PM
Reposted by BeatoLab
Only one week left to apply to the Paris School for Neuroscience Techniques!
parisneuro.ovh
January 24, 2025 at 11:01 AM
Just migrated from 'that place' to this one, hoping to have the same interactions I used to have there
January 22, 2025 at 5:25 PM