The transcriptional regulation of oligodendrocytes has an essential role in myelin formation and maintenance. Here, the authors identify the transcription factor Tfii-i as a regulator of myelin genes expression in the nervous system and show that its loss enhances myelin thickness and nerve conduction.

A single-cell transcriptomic profile of oligodendrocyte precursor cells in the brain across the mouse lifespan reveals aging-associated changes that contribute to the decline of oligodendrogenesis in ...

Early life events shape neuronal networks, and prime juvenile and adult behavior. Severely aversive, early experiences can interfere with brain development and enhance the risk for the onset of psychi...