Harriet Mears
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artisplicer.bsky.social
Harriet Mears
@artisplicer.bsky.social
150 followers 270 following 3 posts
Lecturer at Bristol Uni CMM. Virology and RNA structure. Occasional artist.
She/her 🏳️‍🌈
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Reposted by Harriet Mears
socialinfluenza.bsky.social
Fantastic opportunity (available for both UK and international students) to do a PhD on the assembly of RNA viruses with @artisplicer.bsky.social - please share (and/or apply)!
www.findaphd.com/phds/project...
Funded PhD SWBio DTP- (STANDARD) Genome packaging as a driving force of RNA virus assembly at University of Bristol on FindAPhD.com
PhD Project - Funded PhD SWBio DTP- (STANDARD) Genome packaging as a driving force of RNA virus assembly at University of Bristol, listed on FindAPhD.com
www.findaphd.com
November 7, 2025 at 11:50 AM
Reposted by Harriet Mears
natrevmicro.nature.com
New online! RNA evolution shapes SARS-CoV-2 success
RNA evolution shapes SARS-CoV-2 success
Nature Reviews Microbiology, Published online: 10 February 2025; doi:10.1038/s41579-025-01160-3In this study, Mears et al. show that SARS-CoV-2 can evolve not only through protein changes but also through functional RNA adaptations to increase fitness and…
www.nature.com
February 10, 2025 at 1:29 PM
artisplicer.bsky.social
Four years in the making, our paper is finally out! This was an enormous team effort and a great end to my time at @crick.ac.uk in @davidlvbauer.bsky.social 's lab 🧪🦠🧬
plosbiology.org PLOS Biology @plosbiology.org · Jan 27
#Coronaviruses can evolve the means to generate new RNAs. @artisplicer.bsky.social @davidlvbauer.bsky.social &co identify a subgenomic RNA in #SARSCoV2, producing a C-terminal nucleocapsid fragment that suppresses #interferon signaling & enhances viral fitness 🧪 @plosbiology.org plos.io/4jyUAco
Discontinuous transcription in coronaviruses. Top: Schematic of the SARS-CoV-2 genome. Middle and bottom left: the mechanism of discontinuous transcription for expression of the structural (S, E, M, N) and accessory genes (yellow highlight). Bottom right: Alignment of TRS-Bs upstream of each of the indicated ORFs, compared to the TRS-L.
January 27, 2025 at 7:37 PM