Alex Prados
@aprados.bsky.social
Postdoc at IRB Barcelona in the Battle Lab. Previously, I explored lymphoid organ functions and inflammatory bowel disease in George Kollias' Lab. Excited to launch my independent research as a "Ramon y Cajal" Researcher at UGR in Sept 2025!
Reposted by Alex Prados
3/
👌A tremendous team effort led by Ana Henriques, Maria Salvany-Celades, & Alejandro Prados in the BatlleLab, in collaboration with @paulanietog.bsky.social and @hoheyn.bsky.social, with the help of amazing multidisciplinary teams at @irbbarcelona.org, and @cnag-eu.bsky.social.
Kudos to all 🔝🔝🙌🙌
👌A tremendous team effort led by Ana Henriques, Maria Salvany-Celades, & Alejandro Prados in the BatlleLab, in collaboration with @paulanietog.bsky.social and @hoheyn.bsky.social, with the help of amazing multidisciplinary teams at @irbbarcelona.org, and @cnag-eu.bsky.social.
Kudos to all 🔝🔝🙌🙌
November 7, 2025 at 12:30 PM
3/
👌A tremendous team effort led by Ana Henriques, Maria Salvany-Celades, & Alejandro Prados in the BatlleLab, in collaboration with @paulanietog.bsky.social and @hoheyn.bsky.social, with the help of amazing multidisciplinary teams at @irbbarcelona.org, and @cnag-eu.bsky.social.
Kudos to all 🔝🔝🙌🙌
👌A tremendous team effort led by Ana Henriques, Maria Salvany-Celades, & Alejandro Prados in the BatlleLab, in collaboration with @paulanietog.bsky.social and @hoheyn.bsky.social, with the help of amazing multidisciplinary teams at @irbbarcelona.org, and @cnag-eu.bsky.social.
Kudos to all 🔝🔝🙌🙌
Reposted by Alex Prados
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
www.nature.com
November 7, 2025 at 12:30 PM
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
Reposted by Alex Prados
#PCBCommunity |🧬 Un estudi liderat per @irbbarcelona.org @batllelab.bsky.social i @cnag-eu.bsky.social descobreix com els tumors colorectals metastàtics bloquegen el sistema immunitari mitjançant dos mecanismes complementaris, obrint noves vies per a una #immunoteràpia més eficaç.🔬
👉 tuit.cat/Vr2tw
👉 tuit.cat/Vr2tw
November 7, 2025 at 12:12 PM
#PCBCommunity |🧬 Un estudi liderat per @irbbarcelona.org @batllelab.bsky.social i @cnag-eu.bsky.social descobreix com els tumors colorectals metastàtics bloquegen el sistema immunitari mitjançant dos mecanismes complementaris, obrint noves vies per a una #immunoteràpia més eficaç.🔬
👉 tuit.cat/Vr2tw
👉 tuit.cat/Vr2tw
🚨Excited to share our latest study!🚨
Using TnfΔARE mice & scRNA-seq, we reveal how villus-associated fibroblasts 🔥 ignite inflammation & TLO formation, while trophocytes 🏗️ drive granuloma buildup—shedding new light on fibroblasts' key role in Crohn’s-like ileitis.
#Inflammation #Fibroblasts
Using TnfΔARE mice & scRNA-seq, we reveal how villus-associated fibroblasts 🔥 ignite inflammation & TLO formation, while trophocytes 🏗️ drive granuloma buildup—shedding new light on fibroblasts' key role in Crohn’s-like ileitis.
#Inflammation #Fibroblasts
Different fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis - Nature Communications
The TnfΔΑRE mice overexpress TNF, resulting in ileitis, showing strong similarity to Crohn’s disease in human patients. Here authors describe the immune pathology of the murine disease model by single...
www.nature.com
March 29, 2025 at 10:41 AM
🚨Excited to share our latest study!🚨
Using TnfΔARE mice & scRNA-seq, we reveal how villus-associated fibroblasts 🔥 ignite inflammation & TLO formation, while trophocytes 🏗️ drive granuloma buildup—shedding new light on fibroblasts' key role in Crohn’s-like ileitis.
#Inflammation #Fibroblasts
Using TnfΔARE mice & scRNA-seq, we reveal how villus-associated fibroblasts 🔥 ignite inflammation & TLO formation, while trophocytes 🏗️ drive granuloma buildup—shedding new light on fibroblasts' key role in Crohn’s-like ileitis.
#Inflammation #Fibroblasts
Reposted by Alex Prados
Como ella, muchos estaríamos criando malvas si no existiera la sanidad pública.
Por eso hay que luchar por ella, con uñas y dientes, nos va la vida.
Por eso hay que luchar por ella, con uñas y dientes, nos va la vida.
January 14, 2025 at 6:38 PM
Como ella, muchos estaríamos criando malvas si no existiera la sanidad pública.
Por eso hay que luchar por ella, con uñas y dientes, nos va la vida.
Por eso hay que luchar por ella, con uñas y dientes, nos va la vida.
Reposted by Alex Prados
More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case)
#ImmunoSky
www.nature.com/artic...
#ImmunoSky
www.nature.com/artic...
Targeting immune–fibroblast cell communication in heart failure
Nature - A fibroblast lineage marked by FAP gives rise to POSTN-expressing fibroblasts resembling matrifibrocytes and IL-1β regulates FAP/POSTN fibroblast specification by directly signalling...
www.nature.com
November 15, 2024 at 3:02 PM
More evidence of immune cell (macrophage) -> stromal cell (fibroblast) inflammatory communication to alter organ function (deleteriously, in this case)
#ImmunoSky
www.nature.com/artic...
#ImmunoSky
www.nature.com/artic...
Reposted by Alex Prados
Check out our new paper: a milestone in the establishment of a line-up of in vitro models for #precisionmedicine was reached. In a joint effort with the team of M. Bergmann #MedUni_Wien, we published the first out of several papers in #jitcancer: bit.ly/3YRbsTh 1/n
#Immunology #Immunosky #cancersky
#Immunology #Immunosky #cancersky
Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures
Background Patient-derived colorectal cancer (CRC) organoids (PDOs) solely consisting of malignant cells led to major advances in the understanding of cancer treatments. Yet, a major limitation is the...
bit.ly
November 15, 2024 at 10:48 AM
Check out our new paper: a milestone in the establishment of a line-up of in vitro models for #precisionmedicine was reached. In a joint effort with the team of M. Bergmann #MedUni_Wien, we published the first out of several papers in #jitcancer: bit.ly/3YRbsTh 1/n
#Immunology #Immunosky #cancersky
#Immunology #Immunosky #cancersky
Reposted by Alex Prados
in case this is useful to someone in this massive platform migration: a starting pack for single-cell omics computational methods
go.bsky.app/GmS1cH
go.bsky.app/GmS1cH
single-cell computational methods
Join the conversation
go.bsky.app
November 15, 2024 at 11:11 AM
in case this is useful to someone in this massive platform migration: a starting pack for single-cell omics computational methods
go.bsky.app/GmS1cH
go.bsky.app/GmS1cH
Reposted by Alex Prados
I’m thrilled to share the Pancreatic Cancer Starter Pack! If you want to join DM go.bsky.app/2FHVVL6
November 15, 2024 at 12:15 PM
I’m thrilled to share the Pancreatic Cancer Starter Pack! If you want to join DM go.bsky.app/2FHVVL6