@anunr.bsky.social
FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma: Cancer Cell www.cell.com/cancer-cell/...
A study involving transcriptome profiling to show the combined efficacy of FAKi and avutometinib in melanoma.
A study involving transcriptome profiling to show the combined efficacy of FAKi and avutometinib in melanoma.
FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
By transcriptomic analysis, Lubrano et al. demonstrate that FAK-regulated pathways
are enriched in BRAFi+MEKi-resistant melanoma lesions. In BRAF V600E melanomas, MAPK
inhibition decreases RhoE (RND3)...
www.cell.com
March 2, 2025 at 6:00 AM
FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma: Cancer Cell www.cell.com/cancer-cell/...
A study involving transcriptome profiling to show the combined efficacy of FAKi and avutometinib in melanoma.
A study involving transcriptome profiling to show the combined efficacy of FAKi and avutometinib in melanoma.
Reposted
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
Biomolecular condensates in immune cell fate - Nature Reviews Immunology
Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...
www.nature.com
January 28, 2025 at 4:40 PM
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
Reposted
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 6, 2025 at 7:38 PM
Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Huh. There are flowers in Ethiopia that native nectar-foraging wolves pollinate! 🦊😋🌻🍊
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa
Click on the article title to read more.
esajournals.onlinelibrary.wiley.com
January 11, 2025 at 4:36 PM
Huh. There are flowers in Ethiopia that native nectar-foraging wolves pollinate! 🦊😋🌻🍊
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
🧪
"Canids as pollinators? Nectar foraging by Ethiopian wolves may contribute to the pollination of Kniphofia foliosa"
by Lai et al. (2024, Ecology)
esajournals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted
Intracellular CD28 in triple negative breast cancer cells promotes PD-L1-mediated immune escape
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
December 12, 2024 at 4:58 PM
Intracellular CD28 in triple negative breast cancer cells promotes PD-L1-mediated immune escape
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...