Anna Malkowska
@annamalkowska.bsky.social
PhD student in Andrea Brand's lab at NYU Langone and University of Cambridge, studying epigenomics in neural stem cells 🧬🔬🧠
Pinned
Anna Malkowska
@annamalkowska.bsky.social
· May 16
Neural stem cell quiescence is actively maintained by the epigenome
Homeostasis and repair of the nervous system is maintained by a population of resident neural stem cells (NSCs) retained in a state of reversible cell cycle arrest called quiescence. quiescent NSCs ca...
www.biorxiv.org
Happy to share a preprint of my PhD work! We created a chromatin state model for quiescent and proliferating neural stem cells in Drosophila and found that quiescent cells gain active chromatin to support stem cell functions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Happy to share a preprint of my PhD work! We created a chromatin state model for quiescent and proliferating neural stem cells in Drosophila and found that quiescent cells gain active chromatin to support stem cell functions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Neural stem cell quiescence is actively maintained by the epigenome
Homeostasis and repair of the nervous system is maintained by a population of resident neural stem cells (NSCs) retained in a state of reversible cell cycle arrest called quiescence. quiescent NSCs ca...
www.biorxiv.org
May 16, 2025 at 3:51 PM
Happy to share a preprint of my PhD work! We created a chromatin state model for quiescent and proliferating neural stem cells in Drosophila and found that quiescent cells gain active chromatin to support stem cell functions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anna Malkowska
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes
Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...
doi.org
May 4, 2025 at 7:39 AM
Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....
Reposted by Anna Malkowska
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
April 2, 2025 at 8:47 AM
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
Ready to push some flies
February 21, 2025 at 10:07 PM
Ready to push some flies
Reposted by Anna Malkowska
✨New✨ Brand lab preprint - Quiescent neural stem cells adopt a transient 'stem cell-neuron' identity to coordinate their reactivation across the CNS. We've been discussing the neuron-like traits of quiescent NSCs for years, so it's been wonderful to see Laura and Jocelyn uncover these mechanisms! ⚡
Quiescent neural stem cells transiently become 'neurons' to coordinate reactivation
Reactivation of quiescent neural stem cells (qNSCs) is a coordinated process that generates new neurons and glia. Here, we show that during development reactivation follows a hierarchical sequence, wh...
www.biorxiv.org
November 22, 2024 at 10:51 AM
✨New✨ Brand lab preprint - Quiescent neural stem cells adopt a transient 'stem cell-neuron' identity to coordinate their reactivation across the CNS. We've been discussing the neuron-like traits of quiescent NSCs for years, so it's been wonderful to see Laura and Jocelyn uncover these mechanisms! ⚡