André Mateus
@andrenmateus.bsky.social
Assistant professor at Umeå University and Team leader at the Laboratory for Molecular Infection Medicine Sweden (MIMS)
Follow also lab account: @mateuslab.com
Alumnus at @uu.se and at the @EMBL.org (@savitski-lab.bsky.social and @typaslab.bsky.social)
Follow also lab account: @mateuslab.com
Alumnus at @uu.se and at the @EMBL.org (@savitski-lab.bsky.social and @typaslab.bsky.social)
Reposted by André Mateus
Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen...
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
The pcnB gene sustains Shigella flexneri virulence
Author summary Bacterial infections represent a major global threat. Understanding the genetic determinants promoting infections is crucial to overcome this threat. Shigella is an intracellular bacter...
journals.plos.org
November 21, 2025 at 11:28 AM
Thrilled to share that our study on how the pcnB gene sustains Shigella virulence is now published in PLOS Pathogens: journals.plos.org/plospathogen...
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
In short: pcnB ➝increased virulence-plasmid replication ➝ elevated T3SS expression ➝ enhanced invasion/spread within the intestinal epithelium.
Reposted by André Mateus
Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)!
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Systematic screen uncovers regulator contributions to chemical cues in Escherichia coli
Transport machineries are crucial for antibiotic resistance, but their regulation by external cues is poorly understood. This study identifies environmental chemicals that regulate transporter transcr...
journals.plos.org
July 23, 2025 at 9:15 AM
Finally out! A small screen helps understand a little more about how E. coli regulates major transporters, and reveals how caffeine induces phenotypical antibiotic resistance. Huge thanks to collab @andrenmateus.bsky.social (Umeå) and Christian L. Müller (Munich)!
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
What a fantastic week of science! And it couldn’t have finished in a better way, with Lucia winning one of the best poster awards! #EESMicrobiology
June 27, 2025 at 1:06 PM
Reposted by André Mateus
New preprint out: www.biorxiv.org/content/10.1...
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
www.biorxiv.org
June 17, 2025 at 9:35 AM
New preprint out: www.biorxiv.org/content/10.1...
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
We followed up on our recent Nature Genetics paper mapping Shigella colonization in intestinal organoids with a deep dive into one of the screen hits: pcnB.
#Shigella #virulence #microsky
Reposted by André Mateus
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.
Out @natgenet.nature.com:
rdcu.be/eqGgf
Out @natgenet.nature.com:
rdcu.be/eqGgf
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
June 12, 2025 at 2:14 PM
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.
Out @natgenet.nature.com:
rdcu.be/eqGgf
Out @natgenet.nature.com:
rdcu.be/eqGgf
Reposted by André Mateus
Do we really know the antibiotics that we already have?
Check out our story on 60y old drug nitroxoline and its new tricks!
@goetheuni.bsky.social @embl.org
www.nature.com/articles/s41...
+ great piece from the synchrotron @esrf.fr where we chased nx effects on metals
www.esrf.fr/home/news/ge...
Check out our story on 60y old drug nitroxoline and its new tricks!
@goetheuni.bsky.social @embl.org
www.nature.com/articles/s41...
+ great piece from the synchrotron @esrf.fr where we chased nx effects on metals
www.esrf.fr/home/news/ge...
www.nature.com
April 24, 2025 at 7:16 AM
Do we really know the antibiotics that we already have?
Check out our story on 60y old drug nitroxoline and its new tricks!
@goetheuni.bsky.social @embl.org
www.nature.com/articles/s41...
+ great piece from the synchrotron @esrf.fr where we chased nx effects on metals
www.esrf.fr/home/news/ge...
Check out our story on 60y old drug nitroxoline and its new tricks!
@goetheuni.bsky.social @embl.org
www.nature.com/articles/s41...
+ great piece from the synchrotron @esrf.fr where we chased nx effects on metals
www.esrf.fr/home/news/ge...
Looking forward to speaking in this webinar series next Wednesday.
The future of #DrugDiscovery lies in the untapped #proteome.
Join our experts in our latest 2-part webinar series as they reveal how cutting-edge #proteomics is unlocking novel targets.
🕒 Sign up now: hubs.ly/Q03hBRhj0
Our lineup includes @andrenmateus.bsky.social, @mads-chem.bsky.social and more!
Join our experts in our latest 2-part webinar series as they reveal how cutting-edge #proteomics is unlocking novel targets.
🕒 Sign up now: hubs.ly/Q03hBRhj0
Our lineup includes @andrenmateus.bsky.social, @mads-chem.bsky.social and more!
April 16, 2025 at 5:46 PM
Looking forward to speaking in this webinar series next Wednesday.
So happy to see the first paper on research from the lab out! Just a review for now, but it gives an idea of the avenues we are exploring.
As we start exploring this unique system of O-glycosylation in Bacteroidota species, we have reviewed the current state-of-the-art and offer some ideas on the directions we want to take. #glycotime doi.org/10.1002/2211...
FEBS Press
Species of the Bacteroidota phylum exhibit a unique O-glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species-specific outer g....
doi.org
April 15, 2025 at 11:56 AM
So happy to see the first paper on research from the lab out! Just a review for now, but it gives an idea of the avenues we are exploring.
Reposted by André Mateus
We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...
PhD position in Chemistry, with a specialization in biochemistry
The Department of Chemistry is opening a PhD position in Chemistry with a specialization in biochemistry. The thesis project will focus on drug resistance mechanisms in microbiome species, and is part
umu.varbi.com
March 19, 2025 at 7:36 AM
We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...
Looking forward to sharing with this community what our lab is doing
Seminar in IceLab today! New IceLab affiliated researcher Andre Mateus will talk about functional proteomics of human gut microbiome species at 14:00. https://www.umu.se/en/events/icelab-seminar-with-andre-mateus_12030109/
IceLab affiliate seminar with André Mateus
IceLab affiliate André Mateus, Assistant professor at the Department of Chemistry, will give a talk in IceLab titled ' Functional proteomics of human gut microbiome species' on January 21st at 14:00, in IceLab and through Zoom.
www.umu.se
January 21, 2025 at 8:30 AM
Looking forward to sharing with this community what our lab is doing