Amit Rai
@amitrai01.bsky.social
A non-coding RNA enthusiast. Instructor, Aging and Cardiovascular Discovery Center, Temple University, Philadelphia, PA.
What if cancer immune evasion is driven by metabolites, not mutations?
Tumor-derived metabolites actively suppress immunity and rewire immune cell fate—offering new therapeutic targets.
www.nature.com/articles/s41...
#CancerMetabolism #Immunotherapy #TumorImmunity #TranslationalResearch @nature.com
Tumor-derived metabolites actively suppress immunity and rewire immune cell fate—offering new therapeutic targets.
www.nature.com/articles/s41...
#CancerMetabolism #Immunotherapy #TumorImmunity #TranslationalResearch @nature.com
January 13, 2026 at 2:20 PM
What if cancer immune evasion is driven by metabolites, not mutations?
Tumor-derived metabolites actively suppress immunity and rewire immune cell fate—offering new therapeutic targets.
www.nature.com/articles/s41...
#CancerMetabolism #Immunotherapy #TumorImmunity #TranslationalResearch @nature.com
Tumor-derived metabolites actively suppress immunity and rewire immune cell fate—offering new therapeutic targets.
www.nature.com/articles/s41...
#CancerMetabolism #Immunotherapy #TumorImmunity #TranslationalResearch @nature.com
CIMA maps cell type–specific regulatory networks by integrating scRNA-seq, scATAC-seq & genetics across 10M+ PBMCs, revealing causal links to immune-mediated diseases.
#SingleCell #Genomics #Immunology #MultiOmics #scRNAseq #scATACseq #HumanGenetics @science.org www.science.org/doi/10.1126/...
#SingleCell #Genomics #Immunology #MultiOmics #scRNAseq #scATACseq #HumanGenetics @science.org www.science.org/doi/10.1126/...
Chinese Immune Multi-Omics Atlas
Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), character...
www.science.org
January 10, 2026 at 4:54 AM
CIMA maps cell type–specific regulatory networks by integrating scRNA-seq, scATAC-seq & genetics across 10M+ PBMCs, revealing causal links to immune-mediated diseases.
#SingleCell #Genomics #Immunology #MultiOmics #scRNAseq #scATACseq #HumanGenetics @science.org www.science.org/doi/10.1126/...
#SingleCell #Genomics #Immunology #MultiOmics #scRNAseq #scATACseq #HumanGenetics @science.org www.science.org/doi/10.1126/...
Apoptosis, pyroptosis, necroptosis: distinct pathways, shared chaos.
A conceptual landscape for understanding regulated cell death crosstalk.
#RCD #CellBiology #Apoptosis #pyroptosis
The landscape of regulated cell death: It’s all downhill from here:
@molecular-cell
www.cell.com/molecular-ce...
A conceptual landscape for understanding regulated cell death crosstalk.
#RCD #CellBiology #Apoptosis #pyroptosis
The landscape of regulated cell death: It’s all downhill from here:
@molecular-cell
www.cell.com/molecular-ce...
The landscape of regulated cell death: It’s all downhill from here
The regulated cell death pathways apoptosis, pyroptosis, and necroptosis are connected
on multiple levels. To provide a novel and intuitive conceptual framework of the collaborative
and complex nature...
www.cell.com
January 10, 2026 at 4:42 AM
Apoptosis, pyroptosis, necroptosis: distinct pathways, shared chaos.
A conceptual landscape for understanding regulated cell death crosstalk.
#RCD #CellBiology #Apoptosis #pyroptosis
The landscape of regulated cell death: It’s all downhill from here:
@molecular-cell
www.cell.com/molecular-ce...
A conceptual landscape for understanding regulated cell death crosstalk.
#RCD #CellBiology #Apoptosis #pyroptosis
The landscape of regulated cell death: It’s all downhill from here:
@molecular-cell
www.cell.com/molecular-ce...
Reposted by Amit Rai
Your research has the power to save lives. An American Heart Research Awards gives you the support to make it happen. Applications are open!
December 9, 2025 at 6:00 PM
Your research has the power to save lives. An American Heart Research Awards gives you the support to make it happen. Applications are open!
Reposted by Amit Rai
Nature research paper: An expanded registry of candidate cis-regulatory elements
go.nature.com/4pAbARf
go.nature.com/4pAbARf
An expanded registry of candidate cis-regulatory elements - Nature
The existing ENCODE registry of candidate human and mouse cis-regulatory elements is expanded with the addition of new ENCODE data, integrating new functional data as well as new cell and tissue types.
go.nature.com
January 9, 2026 at 4:25 PM
Nature research paper: An expanded registry of candidate cis-regulatory elements
go.nature.com/4pAbARf
go.nature.com/4pAbARf
Brilliant review by Kory J. Lavine, et al. Single-cell multiomics meets cardioimmunology to reveal immune effector pathways shaping MI, CHD, and AAA.
#CardiovascularImmunology #SingleCell #Omics #HeartResearch @AHAScience @CircRes ahajournals.org/doi/10.1161/CI…
#CardiovascularImmunology #SingleCell #Omics #HeartResearch @AHAScience @CircRes ahajournals.org/doi/10.1161/CI…
January 10, 2026 at 1:32 AM
Brilliant review by Kory J. Lavine, et al. Single-cell multiomics meets cardioimmunology to reveal immune effector pathways shaping MI, CHD, and AAA.
#CardiovascularImmunology #SingleCell #Omics #HeartResearch @AHAScience @CircRes ahajournals.org/doi/10.1161/CI…
#CardiovascularImmunology #SingleCell #Omics #HeartResearch @AHAScience @CircRes ahajournals.org/doi/10.1161/CI…
🚨BREAKING: Starving parents in C. elegans pass on longer lifespans to their kids, because apparently hunger is hereditary, but make it epigenetic. "Eat less, live longer—your great-great-grandworms will thank you".@science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Lysosomes signal through the epigenome to regulate longevity across generations
The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...
www.science.org
September 26, 2025 at 9:53 PM
🚨BREAKING: Starving parents in C. elegans pass on longer lifespans to their kids, because apparently hunger is hereditary, but make it epigenetic. "Eat less, live longer—your great-great-grandworms will thank you".@science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...