Alice Pyne
@alicepyne.bsky.social
UKRIFLF & professor of biophysics at the University of Sheffield. High-resolution #AFM and #biophysics studies of #DNA structure and function www.pyne-lab.uk 🔬🧬 she/her
Reposted by Alice Pyne
📐On #WorldMetrologyDay, we celebrate 150 years of measurement science! At #SPM40, precision at the nanoscale is our mission, advancing biomedical research through AI-powered microscopy. #MetrologyMatters #MSCA #ResearchEU
May 20, 2025 at 2:13 PM
📐On #WorldMetrologyDay, we celebrate 150 years of measurement science! At #SPM40, precision at the nanoscale is our mission, advancing biomedical research through AI-powered microscopy. #MetrologyMatters #MSCA #ResearchEU
Reposted by Alice Pyne
Abstract deadlines coming up soon!
Talk - 14th March
Poster - 28th March
Sign up on our Eventbrite: www.eventbrite.co.uk/e/glasgow-im... and come along and see our wonderful keynote speaker @alicepyne.bsky.social !
For more info, head to the GIN website : glasgowimagingnetwork.wordpress.com
Talk - 14th March
Poster - 28th March
Sign up on our Eventbrite: www.eventbrite.co.uk/e/glasgow-im... and come along and see our wonderful keynote speaker @alicepyne.bsky.social !
For more info, head to the GIN website : glasgowimagingnetwork.wordpress.com
March 6, 2025 at 11:40 AM
Abstract deadlines coming up soon!
Talk - 14th March
Poster - 28th March
Sign up on our Eventbrite: www.eventbrite.co.uk/e/glasgow-im... and come along and see our wonderful keynote speaker @alicepyne.bsky.social !
For more info, head to the GIN website : glasgowimagingnetwork.wordpress.com
Talk - 14th March
Poster - 28th March
Sign up on our Eventbrite: www.eventbrite.co.uk/e/glasgow-im... and come along and see our wonderful keynote speaker @alicepyne.bsky.social !
For more info, head to the GIN website : glasgowimagingnetwork.wordpress.com
Reposted by Alice Pyne
🚨 PhD position available for Oct 25
🔬Using advanced microscopy to understand how keratin networks control tissue mechanics
An interdisciplinary #cellbiology #biophysics collaboration with Ruby Peters & @alicepyne.bsky.social
👇 Apply by March 14
www.findaphd.com/phds/project...
🔬Using advanced microscopy to understand how keratin networks control tissue mechanics
An interdisciplinary #cellbiology #biophysics collaboration with Ruby Peters & @alicepyne.bsky.social
👇 Apply by March 14
www.findaphd.com/phds/project...
February 24, 2025 at 3:29 PM
🚨 PhD position available for Oct 25
🔬Using advanced microscopy to understand how keratin networks control tissue mechanics
An interdisciplinary #cellbiology #biophysics collaboration with Ruby Peters & @alicepyne.bsky.social
👇 Apply by March 14
www.findaphd.com/phds/project...
🔬Using advanced microscopy to understand how keratin networks control tissue mechanics
An interdisciplinary #cellbiology #biophysics collaboration with Ruby Peters & @alicepyne.bsky.social
👇 Apply by March 14
www.findaphd.com/phds/project...
It’s been a busy start to the year with marking, paper and grant reviews and travel to SMB2025 in the US, I think we were delayed for as long as we were actually at the conference…
Its good to be home in the Peak District with my best girl Tasso 🌅 🐕 ❤️
Its good to be home in the Peak District with my best girl Tasso 🌅 🐕 ❤️
January 17, 2025 at 7:03 PM
It’s been a busy start to the year with marking, paper and grant reviews and travel to SMB2025 in the US, I think we were delayed for as long as we were actually at the conference…
Its good to be home in the Peak District with my best girl Tasso 🌅 🐕 ❤️
Its good to be home in the Peak District with my best girl Tasso 🌅 🐕 ❤️
Reposted by Alice Pyne
After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service.
@jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases
Details: cdn.rcsb.org/rcsb-pd...
@jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases
Details: cdn.rcsb.org/rcsb-pd...
EDUCATION CORNER: Molecule of the Month: Celebrating 25 Years of Storytelling and Announcing New Beginnings
After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month series. Janet Iwasa will be continuing the series for PDB-101.
cdn.rcsb.org
January 6, 2025 at 5:12 PM
After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service.
@jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases
Details: cdn.rcsb.org/rcsb-pd...
@jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases
Details: cdn.rcsb.org/rcsb-pd...
Reposted by Alice Pyne
Delighted to share our @NAR_Open paper on a click chemistry-derived DNA damaging agent 🧬✂️👏 Congrats to @westerlundlab.bsky.social @alicepyne.bsky.social @researchireland.bsky.social @dcuresearch.bsky.social @sspc.bsky.social @dublincityuni.bsky.social doi.org/10.1093/nar/...
January 7, 2025 at 12:59 PM
Delighted to share our @NAR_Open paper on a click chemistry-derived DNA damaging agent 🧬✂️👏 Congrats to @westerlundlab.bsky.social @alicepyne.bsky.social @researchireland.bsky.social @dcuresearch.bsky.social @sspc.bsky.social @dublincityuni.bsky.social doi.org/10.1093/nar/...
Reposted by Alice Pyne
Two more weeks to apply to our opening for a senior postdoc in biophysics; work on exciting projects in DNA replication and/or chromatin organization from an interest in instrumentation! Deadline Jan 15 and application link: my.corehr.com/pls/uoxrecru...
January 2, 2025 at 5:47 PM
Two more weeks to apply to our opening for a senior postdoc in biophysics; work on exciting projects in DNA replication and/or chromatin organization from an interest in instrumentation! Deadline Jan 15 and application link: my.corehr.com/pls/uoxrecru...
Today a Tasso jog through Endcliffe park - lots of storm damage with trees uprooted 🐕
December 30, 2024 at 10:50 AM
Today a Tasso jog through Endcliffe park - lots of storm damage with trees uprooted 🐕
Frosty twixmas adventures with Tasso 🤍💚
December 29, 2024 at 4:59 PM
Frosty twixmas adventures with Tasso 🤍💚
A few days of beautiful cloud inversions in the peak. Today a little exploration by bike 🚲- trying to stay above the cloud
December 28, 2024 at 7:04 PM
A few days of beautiful cloud inversions in the peak. Today a little exploration by bike 🚲- trying to stay above the cloud
Boxing Day walks with Tasso, enjoying the #PeakDistrict and thinking how much my mum would have loved to have been with us 💚
December 27, 2024 at 7:55 AM
Boxing Day walks with Tasso, enjoying the #PeakDistrict and thinking how much my mum would have loved to have been with us 💚
First Christmas without maman, thinking of her lots and spending time enjoying the Peak District. She loved it up here 💚
December 25, 2024 at 6:35 PM
First Christmas without maman, thinking of her lots and spending time enjoying the Peak District. She loved it up here 💚
Celebrating the start of longer days with a beautiful sunrise on a morning trot with Tasso 🐕
December 23, 2024 at 12:07 PM
Celebrating the start of longer days with a beautiful sunrise on a morning trot with Tasso 🐕
Only two days left to apply for this amazing opportunity to join Siân’s lab at Kings. Interested in data analysis, microscopy and working with an awesome PI? One not to miss 🔬 💻
Turns out that it's even easier to apply if you have the correct link to follow 🤠
CORRECT LINK: www.jobs.ac.uk/job/DKU906/p...
CORRECT LINK: www.jobs.ac.uk/job/DKU906/p...
December 16, 2024 at 5:00 PM
Only two days left to apply for this amazing opportunity to join Siân’s lab at Kings. Interested in data analysis, microscopy and working with an awesome PI? One not to miss 🔬 💻
Reposted by Alice Pyne
We have a #PhD available! I'm really excited about this project, looking at whether and how differences in the #IDRs of paralogous epigenetic enzymes CBP and p300 cause them to behave differently. www.findaphd.com/phds/project...
Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield on FindAPhD.com
PhD Project - Unveiling the Secrets of Intrinsically Disordered Proteins in Gene Regulation at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
December 5, 2024 at 7:24 AM
We have a #PhD available! I'm really excited about this project, looking at whether and how differences in the #IDRs of paralogous epigenetic enzymes CBP and p300 cause them to behave differently. www.findaphd.com/phds/project...
Reposted by Alice Pyne
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
December 16, 2024 at 11:50 AM
📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...
Reposted by Alice Pyne
Looking for a #biophysics PhD? There's still time to apply for our Yorkshire Biosciences project on how keratin networks affect the mechanical properties of cells & tissues. Interdisciplinary collab with Ruby Peters & @alicepyne.bsky.social.
Deadline 6th Jan
www.findaphd.com/phds/project...
Deadline 6th Jan
www.findaphd.com/phds/project...
The role of keratin networks in maintaining epithelial tissue integrity at University of Sheffield on FindAPhD.com
PhD Project - The role of keratin networks in maintaining epithelial tissue integrity at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
December 16, 2024 at 1:51 PM
Looking for a #biophysics PhD? There's still time to apply for our Yorkshire Biosciences project on how keratin networks affect the mechanical properties of cells & tissues. Interdisciplinary collab with Ruby Peters & @alicepyne.bsky.social.
Deadline 6th Jan
www.findaphd.com/phds/project...
Deadline 6th Jan
www.findaphd.com/phds/project...
On my way to London for the @royalmicrosoc.bsky.social Data Analysis in Microscopy section meeting. Excited to catch up in person with everyone and chat all things 🔬 💻
December 16, 2024 at 12:32 PM
On my way to London for the @royalmicrosoc.bsky.social Data Analysis in Microscopy section meeting. Excited to catch up in person with everyone and chat all things 🔬 💻
A weekend of catching up with old pals from UCL in Hamburg. Tackling the grey drizzle with epic pastries 🥐
December 8, 2024 at 3:27 PM
A weekend of catching up with old pals from UCL in Hamburg. Tackling the grey drizzle with epic pastries 🥐
We were so happy to have @raveentank.bsky.social join us for our first Insigneo Imaging Life workshop in Sheffield this week. It was an amazing day of microscopy🔬 and science 🧪 - thank you Raveen for braving the Manchester-Sheffield train line!
It was a joy to go to Sheffield yesterday to speak at the Insigneo Imaging workshop! There are some really exciting things happening in the super resolution imaging world and I’m excited for the collaborations this has fostered! Thanks for having me Jamie Hobbs and @alicepyne.bsky.social
December 5, 2024 at 1:07 PM
We were so happy to have @raveentank.bsky.social join us for our first Insigneo Imaging Life workshop in Sheffield this week. It was an amazing day of microscopy🔬 and science 🧪 - thank you Raveen for braving the Manchester-Sheffield train line!
Reposted by Alice Pyne
1/ Cancer cell biology MRC DiMeN project in collaboration with @maiblab.bsky.social & Liz Smythe to use recombinant biosensors to image active KRAS in #pancreaticcancer
Apply by 13th Dec
www.findaphd.com/phds/project...
Apply by 13th Dec
www.findaphd.com/phds/project...
MRC DiMeN Doctoral Training Partnership: Understanding the membrane recruitment of oncogenic KRAS in pancreatic cancer at University of Sheffield on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Understanding the membrane recruitment of oncogenic KRAS in pancreatic cancer at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
November 26, 2024 at 3:01 PM
1/ Cancer cell biology MRC DiMeN project in collaboration with @maiblab.bsky.social & Liz Smythe to use recombinant biosensors to image active KRAS in #pancreaticcancer
Apply by 13th Dec
www.findaphd.com/phds/project...
Apply by 13th Dec
www.findaphd.com/phds/project...
Reposted by Alice Pyne
In this paper #AFM is used to image the chain-mail structure of kinetoplast #DNA from parasites and automated analysis unravels the complex molecular topology. 🧪 🔬 🧬
@alicepyne.bsky.social doi.org/10.1039/D4CP...
@alicepyne.bsky.social doi.org/10.1039/D4CP...
Multiscale topological analysis of kinetoplast DNA via high-resolution AFM
Kinetoplast DNA is a complex nanoscale network, naturally assembled from thousands of interconnected DNA circles within the mitochondrion of certain parasites. Despite the relevance of this molecule t...
doi.org
November 22, 2024 at 4:19 PM
In this paper #AFM is used to image the chain-mail structure of kinetoplast #DNA from parasites and automated analysis unravels the complex molecular topology. 🧪 🔬 🧬
@alicepyne.bsky.social doi.org/10.1039/D4CP...
@alicepyne.bsky.social doi.org/10.1039/D4CP...
Reposted by Alice Pyne
The @royalmicrosoc.bsky.social #DataAnalysisInImaging special issue of Journal of Microscopy is out now! onlinelibrary.wiley.com/toc/13652818...
#ImageAnalysis #BioImageAnalysis #RMSDAIM
#ImageAnalysis #BioImageAnalysis #RMSDAIM
Special Issue: Data Analysis in Imaging: Journal of Microscopy: Vol 296, No 3
The <em>Journal of Microscopy</em> is the oldest journal dedicated to the science of microscopy, publishing the latest advances in microscopy techniques and novel areas of application.
onlinelibrary.wiley.com
November 21, 2024 at 3:57 PM
The @royalmicrosoc.bsky.social #DataAnalysisInImaging special issue of Journal of Microscopy is out now! onlinelibrary.wiley.com/toc/13652818...
#ImageAnalysis #BioImageAnalysis #RMSDAIM
#ImageAnalysis #BioImageAnalysis #RMSDAIM
Come join us in Harrogate for a really exciting programme at the interface of the physical and life sciences! Abstract submission is now open, Harrogate is beautiful and the meeting will be really reasonably priced thanks to all our amazing sponsors 🥳
'Physics of Life 2025' is coming to Harrogate, UK, March 24-27!
Explore program sessions, keynote/invited speakers, and submit your abstract here 👉 iop.eventsair.com/pol2025
Registration will be opening very soon! #PoL2025 #PhysicsOfLife
Explore program sessions, keynote/invited speakers, and submit your abstract here 👉 iop.eventsair.com/pol2025
Registration will be opening very soon! #PoL2025 #PhysicsOfLife
November 20, 2024 at 8:05 PM
Come join us in Harrogate for a really exciting programme at the interface of the physical and life sciences! Abstract submission is now open, Harrogate is beautiful and the meeting will be really reasonably priced thanks to all our amazing sponsors 🥳
Reposted by Alice Pyne
I haven't seen a nucleic acids starter pack yet, so I started one! Please reach out if I missed you! go.bsky.app/NxKgUY5
November 18, 2024 at 3:53 PM
I haven't seen a nucleic acids starter pack yet, so I started one! Please reach out if I missed you! go.bsky.app/NxKgUY5