Aleksandra Tata
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alekstata.bsky.social
Aleksandra Tata
@alekstata.bsky.social
93 followers 97 following 5 posts
Assistant Professor in Surgery, Duke University School of Medicine,
Lung 🫁 injury and regeneration/ IPF/ Organoids/Vasculature
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alekstata.bsky.social
www.nature.com/articles/s41...
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition - Nature
The use of two mouse models of pulmonary fibrosis helped the identification of the transcription factor RUNX2 as a regulator of the transition of alveolar fibroblasts to pathological fibroblasts.
www.nature.com
February 6, 2025 at 3:41 PM
Reposted by Aleksandra Tata
nebanovich.bsky.social
Excited to post my first #skySplain about our recent work published yesterday in Nature Genetics! www.nature.com/articles/s41.... One of the first authors of this study - Annika Vannan – actually wrote this breakdown, but she's not yet over here on bluesky and asked me to post!
Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis - Nature Genetics
Xenium spatial transcriptomic profiling of pulmonary fibrosis characterizes cell composition dynamics and histopathological features associated with the disease.
www.nature.com
February 4, 2025 at 2:11 PM
Reposted by Aleksandra Tata
haoyin.bsky.social
#Pericyte #PulmonaryHypertension
1/2

A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH

#SciArt
Ke Yuan lab @embojournal.org 2025
www.embopress.org/doi/full/10....
January 27, 2025 at 1:41 PM
alekstata.bsky.social
www.embopress.org/doi/full/10....
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease | The EMBO Journal
imageimageDisorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable,...
www.embopress.org
January 15, 2025 at 9:26 PM
alekstata.bsky.social
www.cell.com/cell-stem-ce...
Longitudinal single-cell profiles of lung regeneration after viral infection reveal persistent injury-associated cell states
Niethamer, Morrisey, and colleagues delineate the temporal sequence of mouse lung regeneration in a single-cell RNA-sequencing atlas detailing each cellular compartment’s response to influenza infecti...
www.cell.com
January 15, 2025 at 9:22 PM