Amer Alam
@alamlab.bsky.social
Associate Professor @ The Hormel Institute, University of Minnesota
Pinned
Amer Alam
@alamlab.bsky.social
· Jan 13
Structural insights into binding-site access and ligand recognition by human ABCB1 | The EMBO Journal
imageimageABCB1-dependent multidrug resistance is a major cause of reduced efficacy of drug-based
therapy. The cryo-EM-derived structures of ABCB1 presented here reveal a previously
uncharacterized au...
www.embopress.org
www.embopress.org/doi/full/10....
Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social
Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social
Repopulating the feed with our group's earlier work. Structures of human ABCA7 in a lipid environment:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms | The EMBO Journal
image image ABC subfamily A transporter ABCA7 mediates phospholipid extrusion from membranes.
This study provides insights into its molecular mechanism based on cryo‐EM structures
in lipid and deterg...
www.embopress.org
February 15, 2025 at 1:33 PM
Repopulating the feed with our group's earlier work. Structures of human ABCA7 in a lipid environment:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Happy to have contributed to this excellent Methods in Molecular Biology chapter by Rhoderick Brown's lab, now in print.
link.springer.com/protocol/10....
link.springer.com/protocol/10....
Use of Bicelle-Generated Lipid Bilayer Vesicle Nanoparticles for In Vitro Measurement of Lipid Intermembrane Transport
Herein, we describe a straightforward, easy method for generating stable lipid bilayer vesicle nanoparticles and show their usefulness for efficient in vitro tracking of lipid intermembrane transfer a...
link.springer.com
February 13, 2025 at 9:23 PM
Happy to have contributed to this excellent Methods in Molecular Biology chapter by Rhoderick Brown's lab, now in print.
link.springer.com/protocol/10....
link.springer.com/protocol/10....
Reposted by Amer Alam
Structural insights into binding-site access and ligand recognition by human ABCB1 multi drug exporter
Amer Alam and colleagues
www.embopress.org/doi/full/10....
Amer Alam and colleagues
www.embopress.org/doi/full/10....
January 13, 2025 at 4:14 PM
Structural insights into binding-site access and ligand recognition by human ABCB1 multi drug exporter
Amer Alam and colleagues
www.embopress.org/doi/full/10....
Amer Alam and colleagues
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social
Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social
Structural insights into binding-site access and ligand recognition by human ABCB1 | The EMBO Journal
imageimageABCB1-dependent multidrug resistance is a major cause of reduced efficacy of drug-based
therapy. The cryo-EM-derived structures of ABCB1 presented here reveal a previously
uncharacterized au...
www.embopress.org
January 13, 2025 at 2:30 PM
www.embopress.org/doi/full/10....
Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social
Our latest manuscript on human #ABCB1 / #MDR1 / #p-glycoprotein / #pgp / #p-gp structures, No stabilizing antibodies or mutations. 4 conformations including a novel apo state in saposin lipid nanoparticles out in The EMBO Journal @embojournal.bsky.social