Aideen Ryan, BSc, PhD
@aideenryan.bsky.social
Tumour Immunology enthusiast. Group leader at University of Galway. Interested in fibroblasts, stromal cells and anti-tumour immunity. All views are my own.
Pinned
Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...
www.biorxiv.org
Our latest story on the impact of the Sia/Siglec axis and stromal cells in colorectal cancer is online - led by Aoise O’Neill. We identified tgat stromal sualylation shaoes innate immune phenotypes and function. www.biorxiv.org/content/10.1...
Reposted by Aideen Ryan, BSc, PhD
Researchers at the University of Galway have revealed the results of a world-first study into how bowel cancer shuts down the immune system, and how this can be reversed to improve treatment. 🧬
Read more 👉 https://jitc.bmj.com/lookup/doi/10.1136/jitc-2025-012491
Read more 👉 https://jitc.bmj.com/lookup/doi/10.1136/jitc-2025-012491
October 20, 2025 at 10:20 AM
Researchers at the University of Galway have revealed the results of a world-first study into how bowel cancer shuts down the immune system, and how this can be reversed to improve treatment. 🧬
Read more 👉 https://jitc.bmj.com/lookup/doi/10.1136/jitc-2025-012491
Read more 👉 https://jitc.bmj.com/lookup/doi/10.1136/jitc-2025-012491
Reposted by Aideen Ryan, BSc, PhD
Abstract drop - CT269 - First-in-human trial in patients with metastatic colorectal cancer using CRISPR-engineered tumor infiltrating lymphocytes in which the intracellular immune checkpoint CISH is inhibited #AACR25
eppro02.ativ.me/appinfo.php?... #AACR25
eppro02.ativ.me/appinfo.php?... #AACR25
AACR 2025 Annual Meeting Guide
eppro02.ativ.me
April 26, 2025 at 7:28 PM
Abstract drop - CT269 - First-in-human trial in patients with metastatic colorectal cancer using CRISPR-engineered tumor infiltrating lymphocytes in which the intracellular immune checkpoint CISH is inhibited #AACR25
eppro02.ativ.me/appinfo.php?... #AACR25
eppro02.ativ.me/appinfo.php?... #AACR25
Reposted by Aideen Ryan, BSc, PhD
Thrilled to have secured Breakthrough Therapy Designation. This will accelerate our ability to bring #CARTcells to more children with #DIPG and brain & spinal cord tumors.
Breakthrough Therapy designation gives us the possibility to accelerate the development path for BCB-276 as a CAR T-cell therapy to potentially transform treatment of #DIPG, an incurable brain tumor. Our #CARTcells approach opens a new paradigm for other CNS brain tumors.
www.brainchildbio.com/press
www.brainchildbio.com/press
April 22, 2025 at 2:27 PM
Thrilled to have secured Breakthrough Therapy Designation. This will accelerate our ability to bring #CARTcells to more children with #DIPG and brain & spinal cord tumors.
Reposted by Aideen Ryan, BSc, PhD
Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩
March 26, 2025 at 5:29 PM
Last week, the 1st Annual IMPACT conference took place on the shores of Loch Lomond 📍🤩
Reposted by Aideen Ryan, BSc, PhD
With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝
March 26, 2025 at 5:29 PM
With 5 distinct research groups led by @joedwardswwcrc.bsky.social, Campbell Roxburgh, Nigel Jamieson, Colin Steele, and @mcsorleystephen.bsky.social, IMPACT provides a human tissue-based translational research infrastructure in Glasgow, in collaboration with @drpipdunne.bsky.social and Xiao Fu! 🤝
Our latest story on the impact of the Sia/Siglec axis and stromal cells in colorectal cancer is online - led by Aoise O’Neill. We identified tgat stromal sualylation shaoes innate immune phenotypes and function. www.biorxiv.org/content/10.1...
Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis
The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors ...
www.biorxiv.org
March 18, 2025 at 7:41 AM
Our latest story on the impact of the Sia/Siglec axis and stromal cells in colorectal cancer is online - led by Aoise O’Neill. We identified tgat stromal sualylation shaoes innate immune phenotypes and function. www.biorxiv.org/content/10.1...
Reposted by Aideen Ryan, BSc, PhD
Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...
AACR Legislative Action Center
Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...
nam02.safelinks.protection.outlook.com
February 18, 2025 at 10:27 PM
Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...
Reposted by Aideen Ryan, BSc, PhD
@uniofgalway.bsky.social researcher helps the body help itself in the fight against cancer. @aideenryan.bsky.social is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers. tinyurl.com/3x44aa8p
This researcher helps the body help itself in the fight against cancer
University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells with the aim of enhancing the body’s immune response to cancers.
tinyurl.com
February 4, 2025 at 4:25 PM
@uniofgalway.bsky.social researcher helps the body help itself in the fight against cancer. @aideenryan.bsky.social is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers. tinyurl.com/3x44aa8p
Reposted by Aideen Ryan, BSc, PhD
University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers.
This researcher helps the body help itself in the fight against cancer
University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells with the aim of enhancing the body’s immune response to cancers.
www.siliconrepublic.com
January 28, 2025 at 8:07 AM
University of Galway’s Dr Aideen Ryan is looking at mechanisms in supportive tissue cells to enhance the body’s immune response to cancers.
Reposted by Aideen Ryan, BSc, PhD
Failure is always in the background of any creative project; when the experiments are not working or the results don’t seem to make sense. But for discovery, you can’t deny yourself the permission to fail, and we should better teach failure in all its glory.
January 26, 2025 at 6:22 AM
Failure is always in the background of any creative project; when the experiments are not working or the results don’t seem to make sense. But for discovery, you can’t deny yourself the permission to fail, and we should better teach failure in all its glory.
Reposted by Aideen Ryan, BSc, PhD
Grant has been reimagined, rewritten, read by others, revised and submitted! Fingers crossed that it does well. On to the next challenge we go, Sisyphus!
I get knocked down, I get back up again! 💪🏽
I get knocked down, I get back up again! 💪🏽
January 14, 2025 at 2:18 PM
Grant has been reimagined, rewritten, read by others, revised and submitted! Fingers crossed that it does well. On to the next challenge we go, Sisyphus!
I get knocked down, I get back up again! 💪🏽
I get knocked down, I get back up again! 💪🏽
Reposted by Aideen Ryan, BSc, PhD
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
December 11, 2024 at 2:04 PM
Great slide highlighting not only are TILs predictive of pCR...it also translates to being prognostic beyond pCR for good outcome and DFS.
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
Seems like we have a LOT of data on TILs now, why aren't they standardly provided on path reports???🧐
#SABCS24
@oncoalert.bsky.social
@sabcs.bsky.social
Reposted by Aideen Ryan, BSc, PhD
#Bridge2024 coming to a close! Saturday, December 7th 2024 @2:10 pm and we are entering the last session/will cover 1st line #immunotherapy, salvage, igniting change in #cancer #vaccine development, combo IO, #PD1 refractory & more @sitcancer.bsky.social #MSD #BIOTECH #BMS #Merck #Regeneron #UbiVac
December 7, 2024 at 1:26 PM
#Bridge2024 coming to a close! Saturday, December 7th 2024 @2:10 pm and we are entering the last session/will cover 1st line #immunotherapy, salvage, igniting change in #cancer #vaccine development, combo IO, #PD1 refractory & more @sitcancer.bsky.social #MSD #BIOTECH #BMS #Merck #Regeneron #UbiVac
Reposted by Aideen Ryan, BSc, PhD
WORK HARD, PLAY HARD! Celebrate your success & commiserate over failures / #Immunotherapy #Bridge2024 is over & the 15th #Melanoma Bridge has started. Great being in #Napoli with so many friends. PAscierto, Choueiri, Hamid, Tawbi @samirkhleif.bsky.social , Bruno, Guerrero, @sitcancer.bsky.social
December 6, 2024 at 9:45 AM
WORK HARD, PLAY HARD! Celebrate your success & commiserate over failures / #Immunotherapy #Bridge2024 is over & the 15th #Melanoma Bridge has started. Great being in #Napoli with so many friends. PAscierto, Choueiri, Hamid, Tawbi @samirkhleif.bsky.social , Bruno, Guerrero, @sitcancer.bsky.social
Reposted by Aideen Ryan, BSc, PhD
Discussion of Prof Mitch Levesque data / Amazing single cell #melanoma phenotypes/ can it explain resistance? Thinks metabolic signature? Functional data more important
#Bridge2024 @melanomaresearch.bsky.social @impactmelanoma.bsky.social @sitcancer.bsky.social #FinishCancer #PAscierto
#Bridge2024 @melanomaresearch.bsky.social @impactmelanoma.bsky.social @sitcancer.bsky.social #FinishCancer #PAscierto
December 6, 2024 at 10:05 AM
Discussion of Prof Mitch Levesque data / Amazing single cell #melanoma phenotypes/ can it explain resistance? Thinks metabolic signature? Functional data more important
#Bridge2024 @melanomaresearch.bsky.social @impactmelanoma.bsky.social @sitcancer.bsky.social #FinishCancer #PAscierto
#Bridge2024 @melanomaresearch.bsky.social @impactmelanoma.bsky.social @sitcancer.bsky.social #FinishCancer #PAscierto
Reposted by Aideen Ryan, BSc, PhD
Prof Michael Postow #melanoma #immunotherapy Expert @mskcancercenter.bsky.social talks #neoadjuvant treatment.. How many doses of checkpoint blockade? Can we reduce toxicity & maintain efficacy? @sitcancer.bsky.social #Bridge2024 @impactmelanoma.bsky.social @melanomaresearch.bsky.social
December 6, 2024 at 9:05 AM
Prof Michael Postow #melanoma #immunotherapy Expert @mskcancercenter.bsky.social talks #neoadjuvant treatment.. How many doses of checkpoint blockade? Can we reduce toxicity & maintain efficacy? @sitcancer.bsky.social #Bridge2024 @impactmelanoma.bsky.social @melanomaresearch.bsky.social
Reposted by Aideen Ryan, BSc, PhD
More video! Here's my conversation with Nobel-prize winner Katalin Kariko, who pioneered mRNA vaccines. youtu.be/5_9ccDmX3hs?...
City of Science: Katalin Karikó in Conversation with Carl Zimmer
YouTube video by CUNY Graduate Center
youtu.be
December 5, 2024 at 6:00 PM
More video! Here's my conversation with Nobel-prize winner Katalin Kariko, who pioneered mRNA vaccines. youtu.be/5_9ccDmX3hs?...
Congratulations Sid, Courtney and @drpipdunne.bsky.social on your publication in Scientific Reports- a really useful resource to help the field ensure more robust discovery approach using dualGSEA. @researchireland.bsky.social @universityofgalway.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data - Scientific Reports
Scientific Reports - Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data
www.nature.com
December 5, 2024 at 6:19 AM
Congratulations Sid, Courtney and @drpipdunne.bsky.social on your publication in Scientific Reports- a really useful resource to help the field ensure more robust discovery approach using dualGSEA. @researchireland.bsky.social @universityofgalway.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aideen Ryan, BSc, PhD
We have a great line up and we are super excited by all the abstracts we have recieved!
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
https://hubs.la/Q02ZKxQV0
t.co
November 30, 2024 at 9:17 PM
We have a great line up and we are super excited by all the abstracts we have recieved!
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
Reposted by Aideen Ryan, BSc, PhD
💥40 years ago today a 33 y/o dying of #metastatic #melanoma got #LAK & #IL-2 & all #cancer went away! Dr. S.A. #Rosenberg (SAR) had the #immune system #cure a patient/I was in SAR’s lab 85-90/incredible era & energy/Great story in @usatoday.com apple.news/AIcm-M7cDQ-O... @sitcancer.bsky.social
Opinion | Her medical file read 'death imminent.' His treatment plan changed cancer forever. | Opinion — USA TODAY
Immunotherapy is the brightest new weapon in fight against cancer. Thank Dr. Steven Rosenberg, who 40 years ago successfully used it to save a life.
apple.news
November 30, 2024 at 1:32 AM
💥40 years ago today a 33 y/o dying of #metastatic #melanoma got #LAK & #IL-2 & all #cancer went away! Dr. S.A. #Rosenberg (SAR) had the #immune system #cure a patient/I was in SAR’s lab 85-90/incredible era & energy/Great story in @usatoday.com apple.news/AIcm-M7cDQ-O... @sitcancer.bsky.social
Delighted to celebrate Eileen’s, Aoife’s and Jiemen’s graduations yesterday. Three stellar PhD students who were a pleasure to supervise and work with. Wishing them all of the best in their future careers. @researchireland.bsky.social
November 28, 2024 at 9:11 AM
Delighted to celebrate Eileen’s, Aoife’s and Jiemen’s graduations yesterday. Three stellar PhD students who were a pleasure to supervise and work with. Wishing them all of the best in their future careers. @researchireland.bsky.social
Reposted by Aideen Ryan, BSc, PhD
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
November 27, 2024 at 2:13 PM
Only a subset of patients respond to immunotherapy
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Why? Which ones?
We conducted an unbiased analysis of response biomarkers and found that hundreds of possible biomarkers collapse into five latent, orthogonal factors that underlie immunotherapy response.
www.nature.com/articles/s41...
Reposted by Aideen Ryan, BSc, PhD
Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment www.cell.com/cell-reports...
Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
Han et al. identify crosstalk between CAFs and pancreatic cancer cells under hypoxia
and nutrient scarcity. Lysophosphatidylcholines (LPCs), as the key mediators, can
be utilized for phosphatidylcholi...
www.cell.com
November 26, 2024 at 5:54 PM
Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment www.cell.com/cell-reports...
Reposted by Aideen Ryan, BSc, PhD
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
November 25, 2024 at 12:38 PM
Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
So how can we ever achieve #gender #equality?
We discuss various strategies in this #Cell Commentary
#WomeninSTEM
www.cell.com/cell/fulltex...
🧵 1/
Reposted by Aideen Ryan, BSc, PhD
Great article w/ CÚRAM FI Sharon Glynn
at Universityof Galway in TechCentral this week explaining her work on breast cancer and triple negative breast cancer in particular.. Read more at techcentral.ie/focus-on-res... #breastcancerresearch #NOCANCERNETWORK
@researchireland.bsky.social
at Universityof Galway in TechCentral this week explaining her work on breast cancer and triple negative breast cancer in particular.. Read more at techcentral.ie/focus-on-res... #breastcancerresearch #NOCANCERNETWORK
@researchireland.bsky.social
Focus on research: Prof Sharon Glynn, University of Galway - TechCentral.ie
Prof Sharon Glynn is a Professor in Pathology at the University of Galway working with Cúram, the Research Ireland centre for medical devices. In this interview she talks about advancements in the und...
techcentral.ie
November 22, 2024 at 11:43 AM
Great article w/ CÚRAM FI Sharon Glynn
at Universityof Galway in TechCentral this week explaining her work on breast cancer and triple negative breast cancer in particular.. Read more at techcentral.ie/focus-on-res... #breastcancerresearch #NOCANCERNETWORK
@researchireland.bsky.social
at Universityof Galway in TechCentral this week explaining her work on breast cancer and triple negative breast cancer in particular.. Read more at techcentral.ie/focus-on-res... #breastcancerresearch #NOCANCERNETWORK
@researchireland.bsky.social