Abbie Ireland
@abireland.bsky.social
Molecular Cancer Biology PhD student at Duke University ☕️🔬🏳️🌈🐈⬛ she/her
Reposted by Abbie Ireland
Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
Learning the cellular origins across cancers using single-cell chromatin landscapes - Nature Communications
Understanding the cellular origins of cancers is crucial for improving diagnosis and treatment. Here, the authors utilize single cell chromatin accessibility data, patient whole-genome sequencing muta...
www.nature.com
September 17, 2025 at 8:18 PM
Alex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
Reposted by Abbie Ireland
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
rdcu.be/eGUtj
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer
Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...
rdcu.be
September 17, 2025 at 3:21 PM
Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj
rdcu.be/eGUtj
Reposted by Abbie Ireland
SCLC has tremendous plasticity but genetic events constrain it. Tour de force from @abireland.bsky.social
& special thanks to Caris Life Sciences to help validate findings in human tissue. Look out for Alex Tsankov's elegant computational approach supporting the basal origin of #SCLC in Nat Comm.
& special thanks to Caris Life Sciences to help validate findings in human tissue. Look out for Alex Tsankov's elegant computational approach supporting the basal origin of #SCLC in Nat Comm.
September 17, 2025 at 3:21 PM
SCLC has tremendous plasticity but genetic events constrain it. Tour de force from @abireland.bsky.social
& special thanks to Caris Life Sciences to help validate findings in human tissue. Look out for Alex Tsankov's elegant computational approach supporting the basal origin of #SCLC in Nat Comm.
& special thanks to Caris Life Sciences to help validate findings in human tissue. Look out for Alex Tsankov's elegant computational approach supporting the basal origin of #SCLC in Nat Comm.
Reposted by Abbie Ireland
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in #SCLC cancer @nature.com @dukeu.bsky.social @tgoliver.bsky.social @abireland.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 17, 2025 at 5:49 PM
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in #SCLC cancer @nature.com @dukeu.bsky.social @tgoliver.bsky.social @abireland.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Abbie Ireland
Our lab frequently used BioRender to aid our grant submissions and publications—simplifying complex mechanisms of tumor evolution into beautiful schematics! Here is an example in one of our winning grants. #BioRenderForGrants
August 20, 2025 at 10:51 PM
Our lab frequently used BioRender to aid our grant submissions and publications—simplifying complex mechanisms of tumor evolution into beautiful schematics! Here is an example in one of our winning grants. #BioRenderForGrants
Reposted by Abbie Ireland
The basal cell begets SCLC!
@abireland.bsky.social
@abireland.bsky.social
May 10, 2025 at 1:34 AM
The basal cell begets SCLC!
@abireland.bsky.social
@abireland.bsky.social
Spread the word, mark your calendars, and check for your local rally information!
Raleigh, NC — State capitol — 12-4pm. #standupforscience2025
Raleigh, NC — State capitol — 12-4pm. #standupforscience2025
Welcome to the Bluesky account for Stand Up for Science 2025!
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!
#scienceforall #sciencenotsilence
February 25, 2025 at 2:26 PM
Spread the word, mark your calendars, and check for your local rally information!
Raleigh, NC — State capitol — 12-4pm. #standupforscience2025
Raleigh, NC — State capitol — 12-4pm. #standupforscience2025
Reposted by Abbie Ireland
Devastating for scientists and their research, and everyone who benefits from that research.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
NIH appears to have canceled/postponed all of its study sections—the independent review panels that approve federal grants for health research.
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
Such grants fund the work/salaries of 300k people at more than 2,500 institutions
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 11:24 PM
Devastating for scientists and their research, and everyone who benefits from that research.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
I’m not sure if everyone outside academia is aware that a delay or “pause” in grant funding often means the researchers themselves are lost from the field, along with their expertise.
Reposted by Abbie Ireland
Say it with me. They can regulate our words in a document, but they cannot regulate our thoughts, values, attitudes or behavior. Together, we make up nearly 50% of the population. The economy grinds to a halt without us.
Say it with me.
Say it with me.
January 23, 2025 at 1:49 AM
Say it with me. They can regulate our words in a document, but they cannot regulate our thoughts, values, attitudes or behavior. Together, we make up nearly 50% of the population. The economy grinds to a halt without us.
Say it with me.
Say it with me.
Delighted our new work is posted for the world to see! We discover the #basalcell as a likely #SCLC origin that unlocks plasticity towards all fates observed in human tumors—even the POU2F3+ state that has been so “tuft” to model and treat. Check it out! www.biorxiv.org/content/10.1...
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer
Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine cancers, including small cell lun...
www.biorxiv.org
November 16, 2024 at 7:07 PM
Delighted our new work is posted for the world to see! We discover the #basalcell as a likely #SCLC origin that unlocks plasticity towards all fates observed in human tumors—even the POU2F3+ state that has been so “tuft” to model and treat. Check it out! www.biorxiv.org/content/10.1...
Reposted by Abbie Ireland
Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
November 16, 2024 at 1:01 PM
Dear new #science #STEM community-
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:
@abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because: