Abby Bartlett
@abbybartlett.bsky.social
Mitochondrial biology, rare disease awareness and advocacy, writing, and life in (and after!) grad school 💚
Reposted by Abby Bartlett
AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism - Nature Structural & Molecular Biology
Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) ...
doi.org
June 22, 2025 at 11:30 PM
AND IT'S DONE! A 🧵 on our recent article now out in @natsmb.nature.com! Co-led with @abbybartlett.bsky.social, Pagliarini Lab, @judisimcox.bsky.social, we find ACAD10/11 are NOT like other acyl-CoA dehydrogenases and instead catabolize atypical lipids called 4-hydroxy acids 🤯 doi.org/10.1038/s415...
Very excited to see this work with @edreesrashan.bsky.social published in @natsmb.nature.com ! #metabolism #AmazingACADs 🤩
New online: ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism
ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism
Nature Structural & Molecular Biology, Published online: 19 June 2025; doi:10.1038/s41594-025-01596-4Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) that use phosphorylation in their reaction mechanisms.
go.nature.com
June 19, 2025 at 7:10 PM
Very excited to see this work with @edreesrashan.bsky.social published in @natsmb.nature.com ! #metabolism #AmazingACADs 🤩