Andrew Ferns
@5htresearcher.bsky.social
Neuroscience PhD Student | Psychedelic Researcher | Exploring Serotonin’s Role in Aging & Neurodegenerative Disease | Advocate for Evidence-Based Education 🇨🇮🏴
Pinned
I am a first-year PhD student in with a passion for exploring the therapeutic potential of psychedelics and the impact of serotonin signaling in aging and neurodegenerative disease. My mission is to bridge the gap between rigorous scientific research and public understanding of psychedelics.
Booker is a badass
April 1, 2025 at 10:50 PM
Booker is a badass
Very detailed and important work for psychedelic researchers
#PhDSky #AcademicSky #PsychedelicResearch #Neuroscience
#PhDSky #AcademicSky #PsychedelicResearch #Neuroscience
The structural diversity of psychedelic drug actions revealed - Nature Communications
The authors present 7 cryo-EM structures of hallucinogenic and non-hallucinogenic compounds across multiple chemotypes bound to the 5-HT2A receptor, shedding light onto ligand specificity and sig...
www.nature.com
March 20, 2025 at 5:18 PM
Very detailed and important work for psychedelic researchers
#PhDSky #AcademicSky #PsychedelicResearch #Neuroscience
#PhDSky #AcademicSky #PsychedelicResearch #Neuroscience
Psychedelic research everywhere, I love it.
#neuroskyence #psychedelicresearch #neuroscience #science #phdsky
#neuroskyence #psychedelicresearch #neuroscience #science #phdsky
Harnessing psychedelics for stroke recovery: therapeutic potential and mechanisms
Yang et al. propose that psychedelics hold untapped potential for improving stroke recovery through their unique ability to modulate neuroplasticity, reduc
academic.oup.com
March 12, 2025 at 1:33 AM
Psychedelic research everywhere, I love it.
#neuroskyence #psychedelicresearch #neuroscience #science #phdsky
#neuroskyence #psychedelicresearch #neuroscience #science #phdsky
Tristan Jarry is back and on fire 🏒🔥
March 12, 2025 at 1:31 AM
Tristan Jarry is back and on fire 🏒🔥
Astra Lumina, Dallas TX
March 2, 2025 at 1:17 AM
Astra Lumina, Dallas TX
Peacock Streaming, please remove "are you still watching?". It makes it hard to binge The Office for the hundredth time while sick with the flu.
February 20, 2025 at 10:52 PM
Peacock Streaming, please remove "are you still watching?". It makes it hard to binge The Office for the hundredth time while sick with the flu.
Another review supporting psychedelics and NDD
#PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky #AlzSky
#PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky #AlzSky
Frontiers | Psilocybin for the treatment of Alzheimer’s disease
Alzheimer’s disease (AD) stands as a formidable neurodegenerative ailment and a prominent contributor to dementia. The scarcity of available therapies for AD...
www.frontiersin.org
February 15, 2025 at 11:12 PM
Another review supporting psychedelics and NDD
#PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky #AlzSky
#PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky #AlzSky
Rise, like lions after slumber
In unvanquishable number!
Shake your chains to earth like dew
Which in sleep had fallen on you:
Ye are many—they are few!
In unvanquishable number!
Shake your chains to earth like dew
Which in sleep had fallen on you:
Ye are many—they are few!
February 15, 2025 at 11:01 PM
Rise, like lions after slumber
In unvanquishable number!
Shake your chains to earth like dew
Which in sleep had fallen on you:
Ye are many—they are few!
In unvanquishable number!
Shake your chains to earth like dew
Which in sleep had fallen on you:
Ye are many—they are few!
La propriété, c'est le vol!
February 15, 2025 at 11:00 PM
La propriété, c'est le vol!
Just watched The Gorge.... highly recommend.
February 15, 2025 at 10:54 PM
Just watched The Gorge.... highly recommend.
If the 4 Nations Canada team were a real NHL franchise, no other team would ever win the Cup.
February 15, 2025 at 3:29 PM
If the 4 Nations Canada team were a real NHL franchise, no other team would ever win the Cup.
Reposted by Andrew Ferns
Just went live to talk about what is happening, what we can do, and what to expect this week: www.instagram.com/reel/DForuR_...
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www.instagram.com
February 4, 2025 at 4:25 AM
Just went live to talk about what is happening, what we can do, and what to expect this week: www.instagram.com/reel/DForuR_...
Mike O'Malley is a seriously underrated actor
February 4, 2025 at 12:46 AM
Mike O'Malley is a seriously underrated actor
January 27, 2025 at 12:03 AM
On this MLK Day, a reminder of the history behind the dap.
Born from Black soldiers in Vietnam resisting racism and injustice, the dap—short for "dignity and pride"—was their silent language of unity and defiance. Today, it’s a lasting symbol of solidarity and resilience. #MLKDay
Born from Black soldiers in Vietnam resisting racism and injustice, the dap—short for "dignity and pride"—was their silent language of unity and defiance. Today, it’s a lasting symbol of solidarity and resilience. #MLKDay
January 20, 2025 at 12:17 PM
On this MLK Day, a reminder of the history behind the dap.
Born from Black soldiers in Vietnam resisting racism and injustice, the dap—short for "dignity and pride"—was their silent language of unity and defiance. Today, it’s a lasting symbol of solidarity and resilience. #MLKDay
Born from Black soldiers in Vietnam resisting racism and injustice, the dap—short for "dignity and pride"—was their silent language of unity and defiance. Today, it’s a lasting symbol of solidarity and resilience. #MLKDay
Now that we have a felon as president, can we agree that non-violent felons shouldn’t face background checks for housing and jobs? Let’s rethink punitive policies that hurt reintegration and second chances. #JusticeReform #FelonRights #Equality 🧪
January 11, 2025 at 2:39 PM
Now that we have a felon as president, can we agree that non-violent felons shouldn’t face background checks for housing and jobs? Let’s rethink punitive policies that hurt reintegration and second chances. #JusticeReform #FelonRights #Equality 🧪
Birthday present to myself, splurged on cheeses.
January 10, 2025 at 2:34 AM
Birthday present to myself, splurged on cheeses.
Akt signaling is dysfunctional in Alzheimer’s and psychedelics have been shown to modulate this pathway. This paper shows how Akt activation improves memory/synaptic plasticity in AD models. 🧪 #PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky #AlzSky
Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
Protein kinase-B (Akt) and the mechanistic target of rapamycin (mTOR) signaling pathways are implicated in Alzheimer’s disease (AD) pathology. Akt/mTOR signaling pathways, activated by external inputs, enable new protein synthesis at the synapse and synaptic plasticity. The molecular mechanisms impeding new protein synthesis at the synapse in AD pathogenesis remain elusive. Here, we aimed to understand the molecular mechanisms prior to the manifestation of histopathological hallmarks by characterizing Akt1/mTOR signaling cascades and new protein synthesis in the hippocampus of WT and amyloid precursor protein/presenilin-1 (APP/PS1) male mice.
www.jbc.org
January 7, 2025 at 1:13 PM
Akt signaling is dysfunctional in Alzheimer’s and psychedelics have been shown to modulate this pathway. This paper shows how Akt activation improves memory/synaptic plasticity in AD models. 🧪 #PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky #AlzSky
🧪🧠 A 2016 paper shows 5-HT1A activation reduces p-tau in vitro. Since psychedelics also activate 5-HT1A, they could potentially reduce Alzheimer's disease pathologies. A promising avenue for NDD research. #PhDSky #PsychedelicResearch #AcademicSky #AlzSky
Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT 1A receptor mediated Akt/GSK-3β pathway | Oncotarget
https://doi.org/10.18632/oncotarget.7798 Yan-Juan Wang, Qing-Guo Ren, Wei-Gang Gong, Di Wu, Xiang Tang, Xiao-Li Li, Fang-Fang Wu, Feng Bai, Lin Xu, Zhi-Jun Zhang
www.oncotarget.com
January 5, 2025 at 9:41 PM
🧪🧠 A 2016 paper shows 5-HT1A activation reduces p-tau in vitro. Since psychedelics also activate 5-HT1A, they could potentially reduce Alzheimer's disease pathologies. A promising avenue for NDD research. #PhDSky #PsychedelicResearch #AcademicSky #AlzSky
Recent study into the use of the icv-STZ model to mimic sporadic Alzheimer's disease (sAD), which accounts for most AD cases. Unlike familial AD models, icv-STZ reflects real-world complexity, urging more focus on sAD-specific research. 🧪 #NeuroSkyence #PsychedelicResearch #AcademicSky #PhDSky
Proteomic Analysis of a Rat Streptozotocin Model Shows Dysregulated Biological Pathways Implicated in Alzheimer’s Disease
Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive memory loss and cognitive impairment, affecting 35 million individuals worldwide. Intracerebroventric...
www.mdpi.com
January 4, 2025 at 5:48 PM
Recent study into the use of the icv-STZ model to mimic sporadic Alzheimer's disease (sAD), which accounts for most AD cases. Unlike familial AD models, icv-STZ reflects real-world complexity, urging more focus on sAD-specific research. 🧪 #NeuroSkyence #PsychedelicResearch #AcademicSky #PhDSky
Texas HB 1802 was a step forward for psychedelic research, but limiting the focus to mental health overlooks their potential for treating neurodegenerative diseases and more. Let's support psychedelic research in all areas of science! 🧪 #PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky
January 3, 2025 at 1:18 PM
Texas HB 1802 was a step forward for psychedelic research, but limiting the focus to mental health overlooks their potential for treating neurodegenerative diseases and more. Let's support psychedelic research in all areas of science! 🧪 #PhDSky #NeuroSkyence #PsychedelicResearch #AcademicSky
Activation of the 5-HT₂A receptor by serotonin increases the secretion of soluble amyloid precursor protein, potentially reducing amyloid-beta formation associated with Alzheimer's disease. Guess what else activates the 5-HT₂A receptor? #PhDSky #Neuroscience #PsychedelicResearch #AcademicSky🧪
Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion (∗)
Alzheimer's disease amyloid consists of amyloid β-peptides (Aβ) derived from the larger precursor amyloid precursor protein (APP). Non-amyloidogenic APP processing involves regulated cleavage within the Aβ domain followed by secretion of the ectodomain (APPs). APPs secretion can be stimulated by muscarinic acetylcholine receptors coupled to phospholipases and kinases. To determine whether other receptor classes can regulate APP processing, we examined the relation between serotonin receptors and APPs secretion.
www.jbc.org
January 1, 2025 at 10:35 PM
Activation of the 5-HT₂A receptor by serotonin increases the secretion of soluble amyloid precursor protein, potentially reducing amyloid-beta formation associated with Alzheimer's disease. Guess what else activates the 5-HT₂A receptor? #PhDSky #Neuroscience #PsychedelicResearch #AcademicSky🧪
Reposted by Andrew Ferns
Happy New Year everyone 🎊 Excited to be completing my first #book “How #Psychedelics Work” early in the new year. 12/13 chapters written. As I say in the intro, it could just as easily have been titled differently, like these:
January 1, 2025 at 3:45 PM
Happy New Year everyone 🎊 Excited to be completing my first #book “How #Psychedelics Work” early in the new year. 12/13 chapters written. As I say in the intro, it could just as easily have been titled differently, like these:
Follow my research on psychedelics and neurodegenerative diseases as I explore how serotonergic modulation may address pathological mechanisms in Alzheimer’s and beyond. Let’s connect on LinkedIn: www.linkedin.com/in/5htresear... 🧪 #PhDSky #Neuroscience #PsychedelicResearch #AcademicSky
www.linkedin.com
January 1, 2025 at 3:35 PM
Follow my research on psychedelics and neurodegenerative diseases as I explore how serotonergic modulation may address pathological mechanisms in Alzheimer’s and beyond. Let’s connect on LinkedIn: www.linkedin.com/in/5htresear... 🧪 #PhDSky #Neuroscience #PsychedelicResearch #AcademicSky