This was a dream that one of my bosses (and certainly others) had in the mid-1990’s.
Naturally occurring enzymes, while powerful, catalyze only a fraction of the reactions chemists care about. That’s why scientists are eager to design new-to-nature versions that could carry out entirely new forms of chemistry that biology never evolved. cen.acs.org/physical-che...
#chemsky 🧪
#chemsky 🧪
A trio of AI methods tackles enzyme design
RFdiffusion2, RFdiffusion3, and Riff-Diff each solve different structural problems in computational enzyme design
cen.acs.org
January 4, 2026 at 11:49 AM
This was a dream that one of my bosses (and certainly others) had in the mid-1990’s.
Weird. Why does the category ‘replies’ now include non-replies? Aren’t replies a subset of posts?
January 4, 2026 at 11:44 AM
Weird. Why does the category ‘replies’ now include non-replies? Aren’t replies a subset of posts?
It’s foolish to expect peace in any part of the world when peace is not known in the hearts of people.
January 3, 2026 at 2:52 PM
It’s foolish to expect peace in any part of the world when peace is not known in the hearts of people.
After some contemplation, I think that any conceptual division of us and them is incredibly harmful.
I wish I had more facility with language.
I wish I had more facility with language.
January 3, 2026 at 2:41 PM
After some contemplation, I think that any conceptual division of us and them is incredibly harmful.
I wish I had more facility with language.
I wish I had more facility with language.
Everything I start typing sounds like a complete non-sequitur.
January 3, 2026 at 11:57 AM
Everything I start typing sounds like a complete non-sequitur.
I keep trying to put words together but it’s useless.
January 3, 2026 at 11:31 AM
I keep trying to put words together but it’s useless.
“government of the people, by the people, for the people” has perished from the earth.
January 3, 2026 at 11:19 AM
“government of the people, by the people, for the people” has perished from the earth.
I am again reminded why I didn’t try to buy a house again after I sold my condo when I had to relocate. Maintaining any property requires vigilance, access to knowledgable tradespeople and money.
January 2, 2026 at 9:13 PM
I am again reminded why I didn’t try to buy a house again after I sold my condo when I had to relocate. Maintaining any property requires vigilance, access to knowledgable tradespeople and money.
Reposted by Cheryl
These worthless fuckers are too inept to drive on light snow cover, too unprepared to have a shovel, too lazy to get out and push, and too stupid to realize spinning their wheels in place will just make it worse.
"Defend the Homeland"?
They can't even defend themselves from a mild MN winter.
"Defend the Homeland"?
They can't even defend themselves from a mild MN winter.
January 2, 2026 at 8:46 PM
These worthless fuckers are too inept to drive on light snow cover, too unprepared to have a shovel, too lazy to get out and push, and too stupid to realize spinning their wheels in place will just make it worse.
"Defend the Homeland"?
They can't even defend themselves from a mild MN winter.
"Defend the Homeland"?
They can't even defend themselves from a mild MN winter.
Today I aim to, among necessities, take another stab at reading the book (treatise?) that I ordered from the library. I started yesterday but it was tough because a lot of it is based on an assumption that I don’t ascribe to. It’s a bit like doing math without proving 1+1=2.
January 2, 2026 at 12:10 PM
Today I aim to, among necessities, take another stab at reading the book (treatise?) that I ordered from the library. I started yesterday but it was tough because a lot of it is based on an assumption that I don’t ascribe to. It’s a bit like doing math without proving 1+1=2.
Reposted by Cheryl
A List of Predictions Made in 1926 About 2026
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January 1, 2026 at 5:13 PM
A List of Predictions Made in 1926 About 2026
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Another YB song from Jaejoong, this time a cover of A flying butterfly.
JYJ 김재중, 군복입고 부른 "나는 나비"~!
YouTube video by KFN
youtu.be
December 31, 2025 at 9:35 PM
Another YB song from Jaejoong, this time a cover of A flying butterfly.
Now is Good
131102 KIMJAEJOONG 1st Album Asia Tour Concert_Now Is Good
YouTube video by MELITEHEROJJ
youtu.be
December 31, 2025 at 9:27 PM
Now is Good
This is an incredible throwback! The very first full album I bought when I started paying attention to Korean music was YB’s Why Be. Later, Yoon Do Hyun wrote “Now is good” for JaeJoong. Now Seungmin of SKZ performed Peppermint Candy with YB!
[2025 MBC 가요대제전] YB X SEUNGMIN (Stray Kids) (YB X 승민) - Stormborn + 박하사탕, MBC 251231 방송
YouTube video by MBCkpop
youtu.be
December 31, 2025 at 8:53 PM
This is an incredible throwback! The very first full album I bought when I started paying attention to Korean music was YB’s Why Be. Later, Yoon Do Hyun wrote “Now is good” for JaeJoong. Now Seungmin of SKZ performed Peppermint Candy with YB!
Goodbye MTV
TORA TORA - walkin' shoes
YouTube video by bahbahbahou812
youtu.be
December 31, 2025 at 8:02 PM
Goodbye MTV
Reposted by Cheryl
I’m facilitating the rehoming of two sweet cats who belonged to a friend who recently passed unexpectedly. They deserve a stable place to land. 2-3 year old bonded pair, one male one female. Please send me a DM if you have the interest and ability to care for these sweet voids. Located in Oakland.
December 31, 2025 at 6:22 AM
Trying not to panic in front of my dad seems to have become my daily practice.
December 30, 2025 at 3:44 PM
Trying not to panic in front of my dad seems to have become my daily practice.
Yesterday I decided that today should be a day of rest & recovery. So far, that hasn’t come to fruition. Do I even know how to effectively rest?
December 29, 2025 at 5:40 PM
Yesterday I decided that today should be a day of rest & recovery. So far, that hasn’t come to fruition. Do I even know how to effectively rest?
Today I wanted something to listen to as I rested. Somewhat at random I chose a discussion that I thought would be bland. (The topic wasn’t current events.) But, the ending Q&A seemed to be addressing situations in 2025. When I looked, I was surprised to find it was recorded in early 2006.
December 29, 2025 at 5:23 PM
Today I wanted something to listen to as I rested. Somewhat at random I chose a discussion that I thought would be bland. (The topic wasn’t current events.) But, the ending Q&A seemed to be addressing situations in 2025. When I looked, I was surprised to find it was recorded in early 2006.
A 40°F drop in temperatures in less than 8 hours seems a bit unusual. Hey Mother Nature, let’s not do this too often, yeah?
December 29, 2025 at 4:52 AM
A 40°F drop in temperatures in less than 8 hours seems a bit unusual. Hey Mother Nature, let’s not do this too often, yeah?
It might take me until well into 2026 to recover from this last week. I’m glad my siblings did manage to do a few of the things that I asked them to do for dad. Now the rest has to get integrated into the new year to-do list.
December 28, 2025 at 2:34 PM
It might take me until well into 2026 to recover from this last week. I’m glad my siblings did manage to do a few of the things that I asked them to do for dad. Now the rest has to get integrated into the new year to-do list.
Pet parents. Don’t bring your enthusiastic dog into a cat’s territory without warning and off leash - especially if you know that your dog doesn’t typically get along with cats. If it had been my house and my cats, you would have been sent home.
December 28, 2025 at 4:37 AM
Pet parents. Don’t bring your enthusiastic dog into a cat’s territory without warning and off leash - especially if you know that your dog doesn’t typically get along with cats. If it had been my house and my cats, you would have been sent home.
It’s too early to use words. Just posted two sentences and both started with a form of ‘interesting.’
December 27, 2025 at 12:22 PM
It’s too early to use words. Just posted two sentences and both started with a form of ‘interesting.’