Gordon H. Guyatt
@guyattgh.bsky.social
Promoting use of the best evidence and patient values and preferences to inform optimal clinical and health policy decisions.
Gordon Henry Guyatt is a Canadian physician who is a professor at McMaster University in Hamilton, Ontario. He is known for his leadership in evidence-based medicine, a term that first appeared in a single-author paper he published in 1991. Subsequently, a 1992 JAMA article led by Guyatt proved instrumental in bringing the concept of evidence-based medicine to the world's attention. Guyatt's concerns with the role of the medical system, social justice, and medical reform remain central issues that he promoted in tandem with his medical work. He was named to the Canadian Medical Hall of Fame in 2015. .. more
Economics
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Mathematics
24%
#grade | Gordon Guyatt
In this one minute tutorial, I explain the meaning and significance of a weak or conditional #GRADE recommendation.
Leticia Kawano-Dourado, MD, PhD
www.linkedin.com
In this one minute tutorial, I explain the meaning and significance of a weak or conditional #GRADE recommendation.
www.linkedin.com/feed/update/...
www.linkedin.com/feed/update/...
A clinician's guide for conducting randomized trials in individual patients
In determining optimal treatment for a patient conventional trials of therapy are susceptible to bias. Large-scale randomized trials can provide only a partial guide and have not been or cannot be car...
www.cmaj.ca
Anyone interested in determining the effect of a drug in a single patient by conducting a #RandomizedTrial in a that patient – an N of 1 trial – will find this step-by-step guide enormously useful.
www.cmaj.ca/content/139/...
www.cmaj.ca/content/139/...
GRADE guidelines: 21 part 1. Study design, risk of bias, and indirectness in rating the certainty across a body of evidence for test accuracy - PubMed
Rating the certainty of a body of evidence using GRADE in Cochrane and other reviews and World Health Organization and other guidelines dealing with in TA studies helped refining our approach. The resulting guidance will help applying GRADE successfully for questions and recommendations focusing on …
pubmed.ncbi.nlm.nih.gov
If you are using #GRADE to rate #CertaintyofEvidence for diagnostic tests this article that deals with study design, #RiskofBias, and #indirectness provides crucial guidance.
pubmed.ncbi.nlm.nih.gov/32060007/
pubmed.ncbi.nlm.nih.gov/32060007/
Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis - PubMed
In this systematic review and meta-analysis of randomized trials, there was moderate certainty evidence that corticosteroids were associated with an increased risk of hyperglycemia and sleep problems and low certainty evidence that corticosteroids were associated with increased risk of gastrointesti …
pubmed.ncbi.nlm.nih.gov
Just published #MetaAnalysis of #AdverseEffects of short-course #steroids in #children and #adolescents in many diseases can provide high certainty evidence for their use in #RareDisease. Generally applicable approach for harms of common drugs in rare diseases.
pubmed.ncbi.nlm.nih.gov/41026484/
pubmed.ncbi.nlm.nih.gov/41026484/
Shared decision-making as a method of care
Care happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover or develop a shared understanding of the problematic situation of the patient...
ebm.bmj.com
Forming #EvidenceBased plans of #EBM care that respond to each patient’s situation demands #SharedDecisionMaking. JP Brito, Iris Hargraves, and Marleen Kunneman are doing leading work to advance the practice of making care fit using shared decision making.
ebm.bmj.com/content/28/4...
ebm.bmj.com/content/28/4...
#evidencbasedmedicine #ebm | Gordon Guyatt
This video presents a 16 second answer to the question of how #EvidencBasedMedicine - #EBM - protects us against inflated, misleading claims of treatment effect. I’ll be posting a number of such snipp...
www.linkedin.com
This video presents a answer to the question of how evidence-based medicine - #EBM - protects us against inflated, misleading claims of treatment effect. I’ll be posting a number of such snippets and you’ll enjoy my charming interlocutor,
@leticiakawano.bsky.social
www.linkedin.com/feed/update/...
@leticiakawano.bsky.social
www.linkedin.com/feed/update/...
Tranexamic Acid in Patients Undergoing Noncardiac Surgery | NEJM
Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic
acid is an antifibrinolytic drug that may safely decrease such bleeding. We conducted
a trial involving patien...
www.nejm.org
The ground-breaking #NEJM #randomizedTrial suggests that every #surgery patient at substantial #bleeding risk should receive #tranexamicAcid: 24% #RelativeRisk reduction in serious bleeding.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Thomas Agoritsas
edhub.ama-assn.org
15 minute #JAMA podcast in which I interview world authority @thomasagoritsas.bsky.social on how to Use a Patient Management #Recommendations: #ClinicalPracticeGuidelines and #DecisionAnalyses
edhub.ama-assn.org/jn-learning/...
edhub.ama-assn.org/jn-learning/...
Potential impact on estimated treatment effects of information lost to follow-up in randomised controlled trials (LOST-IT): systematic review - PubMed
Plausible assumptions regarding outcomes of patients lost to follow-up could change the interpretation of results of randomised controlled trials published in top medical journals.
pubmed.ncbi.nlm.nih.gov
This #BMJ article demonstrates that plausible assumptions regarding outcomes of patients lost to follow-up could often change the interpretation of results of #RandomisedControlledTrials published in top medical journals.
pubmed.ncbi.nlm.nih.gov/22611167/
pubmed.ncbi.nlm.nih.gov/22611167/
Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses - PubMed
The fixed effects OR, random effects OR and random effects RR appear to be reasonably constant across different baseline risks. Given the interpretational and arithmetic ease of RR, clinicians may wis...
pubmed.ncbi.nlm.nih.gov
Are #RelativeRisks overwhelmingly similar across risk groups? And if so, can we personalize care by applying relative risk to individual patients’ risk profiles? This key #EBM study demonstrates that the answer to both questions is an unquestionable YES.
pubmed.ncbi.nlm.nih.gov/11914297/
pubmed.ncbi.nlm.nih.gov/11914297/
Trustworthiness of treatment clinical practice guidelines has modestly improved since the introduction of Institute of Medicine standards: a systematic survey - PubMed
As assessed by the modified NEATS instrument, although trustworthiness of treatment guidelines has improved after the introduction of IOM standards, improvements proved modest and post-IOM guidelines ...
pubmed.ncbi.nlm.nih.gov
A survey addresses #guidelines trustworthiness evolution 2010 to 2022. Glass half empty - modest improvement, long way to go; and half full - almost 20% high trustworthiness. Thousands published yearly, astute clinicians will find quality guidelines relevant to them
pubmed.ncbi.nlm.nih.gov/40889618/
pubmed.ncbi.nlm.nih.gov/40889618/
CHART - Chatbot Assessment Reporting Tool
CHART: A comprehensive reporting guideline for Chatbot Health Advice studies
chartguideline.org
Studies being published checking whether #LLMs and other #generativeAI models provide good health advice. #Clinicians, #Researchers, #Reviewers, #Editors, #Publishers can check and optimize studies through the #CHART checklist, abstract checklist, and methodological diagram.
chartguideline.org
chartguideline.org