Bernhard Y. Renard

Judith Bernett @judith-bernett.bsky.social · Jun 3

🧬🖥️So excited to show you the outcome of @pascivers.bsky.social and my latest project: "From Hype to Health Check: Critical Evaluation of Drug Response Prediction Models with DrEval" doi.org/10.1101/2025.05.26.655288, published with M. Picciani, M. Wilhelm, K. Baum & @itisalist.bsky.social.
🧵1/10

Overview of the DrEval framework. Via input options, implemented state-of-the-art models can be compared against baselines of varying complexity. We address obstacles to progress in the field at each point in our pipeline: Our framework is available on PyPI and nf-core and we follow FAIReR standards for optimal reproducibility. DrEval is easily extendable as demonstrated here with a pseudocode implementation of a proteomics-based random forest. Custom viability data can be preprocessed with CurveCurator, leading to more consistent data and metrics. DrEval supports five widely used datasets with application-aware train/test splits that enable detecting weak generalization. Models are free to use provided or custom cell line– and drug features. The pipeline supports randomization-based ablation studies and performs robust hyperparameter tuning for all models. Evaluation is conducted using meaningful, bias-resistant metrics to avoid inflated results from artifacts such as Simpson’s paradox. All results are compiled into an interactive HTML report. Created in https://BioRender.com.

Renard Lab @renardlab.bsky.social · May 30

What a run! 🏃‍♀️🏃‍♂️
Last week, our group took part in the Berlin #Firmenlauf, and we had an amazing time out there, running, cheering each other on, and just enjoying the energy of the event! #TeamVibes

Thanks to everyone who made it such a memorable day 🤗 #ScienceInSneakers @hpi.bsky.social

Renard Lab @renardlab.bsky.social · Mar 6

In his project in collaboration with the Icahn School of Medicine at Mount Sinai @hpims.bsky.social, he is exploring the effect of biological administration timing on treatment outcomes in patients with Inflammatory Bowel Disease. Supervised by Dr. Susanne Ibing @sibing.bsky.social.

Renard Lab @renardlab.bsky.social · Mar 6

We're proud to have Akin present his ongoing master's thesis project at the European Crohn's and Colitis Organisation (ECCO)
Congress 2025!

Akin joyously standing in front of his poster titled “Morning administration of biological therapy is associated with decreased risk of treatment failure in patients with Inflammatory Bowel Disease” at the European Crohn’s and Colitis Organisation (ECCO) congress!

Helene Kretzmer @helenekretzmer.bsky.social · Mar 2

We’re excited to share that our paper on rapid molecular classification of brain tumors has just been published in Nature Medicine!

Renard Lab @renardlab.bsky.social · Feb 11

Check out the awesome opportunity to join the group of one of the brilliant minds at our chair!

Jakub Bartoszewicz @jmbartoszewicz.bsky.social · Feb 11

I'm setting up my lab at @hpi.bsky.social, on the edge of vibrant Berlin! PhD/postdoc positions in AI for safe synthetic biology & infectious diseases (AMR), in collab with @melanianowicka.bsky.social.

Apply by Feb 24: email firstname.lastname@hpi.de with “[Open-25]” in the subject. DM for details!

Jakub Bartoszewicz @jmbartoszewicz.bsky.social · Feb 11

I'm setting up my lab at @hpi.bsky.social, on the edge of vibrant Berlin! PhD/postdoc positions in AI for safe synthetic biology & infectious diseases (AMR), in collab with @melanianowicka.bsky.social.

Apply by Feb 24: email firstname.lastname@hpi.de with “[Open-25]” in the subject. DM for details!

Renard Lab @renardlab.bsky.social · Feb 7

Her work produces daily immunity indices for each regional location, given vaccination and infection data for different infectious diseases, which in turn can be used to, e.g., predict the spread of disease 🧬🤧🌐

Renard Lab @renardlab.bsky.social · Feb 7

Ferdous Nasri presenting her work on the 'Spatio-temporal immunity index tool for infectious diseases' at the Digital Health Summit at University of Cape Town in South Africa!

Renard Lab @renardlab.bsky.social · Jan 31

She has published numerous papers and presented her work at various conferences.

Her next step will focus on her research collaborations across the atlantic. 🚀

Renard Lab @renardlab.bsky.social · Jan 31

Her achievements are outstanding and we are very proud to be celebrating this day with her!💐

She started her PhD as a part of the Böttinger Lab, spent some time working with Mount Sinai in NY and switched to our Lab later. She led projects with many students, one of which won the DMEA Sparks Award🏆

Renard Lab @renardlab.bsky.social · Jan 31

💐Congratulations to ✨ Dr. Susanne Ibing! 🎓

Susanne, @sibing.bsky.social, successfully defended her doctoral dissertation @hpi.bsky.social this month on “Computational Strategies for Chronic Disease Characterization and Treatment by Leveraging Electronic Health Records and Omics Data” 🩻🧬👩🏼‍💻