These proposals won’t reduce the numbers applying for asylum here, nor, therefore, will it spike Farage’s guns. What it *will* do is further open the door to Reform by a) demonising and dehumanising all immigrants by association, and b) failing to assuage the fears it is helping to stir up.
November 18, 2025 at 1:30 PM
These proposals won’t reduce the numbers applying for asylum here, nor, therefore, will it spike Farage’s guns. What it *will* do is further open the door to Reform by a) demonising and dehumanising all immigrants by association, and b) failing to assuage the fears it is helping to stir up.
An "unusual spike in traffic" usually means a hacker, correct?
November 18, 2025 at 1:30 PM
An "unusual spike in traffic" usually means a hacker, correct?
At the PolyBio symposium, Dr Lael Yonker presented pediatric Long COVID research. Her team is studying how neutrophils respond in children and whether viral reservoirs in the gut allow spike protein to enter the bloodstream and trigger NET release.
@polybiorf.bsky.social
@polybiorf.bsky.social
November 18, 2025 at 1:26 PM
At the PolyBio symposium, Dr Lael Yonker presented pediatric Long COVID research. Her team is studying how neutrophils respond in children and whether viral reservoirs in the gut allow spike protein to enter the bloodstream and trigger NET release.
@polybiorf.bsky.social
@polybiorf.bsky.social
I've been rewatching stuff about super old creepypastas that scared me as a kid and I'm not scared of sonic.exe any more but I'm definitely still feeling my heartrate spike at all the horrific tails death scenes
November 18, 2025 at 1:24 PM
I've been rewatching stuff about super old creepypastas that scared me as a kid and I'm not scared of sonic.exe any more but I'm definitely still feeling my heartrate spike at all the horrific tails death scenes
GOOG +12%, PLTR breaking out, AVGO earnings beat, TSM AI demand surge, AMD momentum.
My quant model projects these 5 stocks could spike 15-30% in July.
Full technicals & entry points ready.
🔗 https://discord.
My quant model projects these 5 stocks could spike 15-30% in July.
Full technicals & entry points ready.
🔗 https://discord.
November 18, 2025 at 1:22 PM
GOOG +12%, PLTR breaking out, AVGO earnings beat, TSM AI demand surge, AMD momentum.
My quant model projects these 5 stocks could spike 15-30% in July.
Full technicals & entry points ready.
🔗 https://discord.
My quant model projects these 5 stocks could spike 15-30% in July.
Full technicals & entry points ready.
🔗 https://discord.
Cloudflare’s global network is having an “internal server error / service degradation” it started early this morning (around 6–7 a.m. ET). That’s causing a spike in 5xx errors on tons of sites that use Cloudflare as a proxy, CDN, or security layer.
November 18, 2025 at 1:16 PM
Cloudflare’s global network is having an “internal server error / service degradation” it started early this morning (around 6–7 a.m. ET). That’s causing a spike in 5xx errors on tons of sites that use Cloudflare as a proxy, CDN, or security layer.
Will all the black bars over trump’s name cause a spike in the price of ink or toner?
November 18, 2025 at 1:16 PM
Will all the black bars over trump’s name cause a spike in the price of ink or toner?
Happy National Vichyssoise Day!
Lola called vichyssoise “the soup that wears a sweater.” Spike explained it’s just chilled potato-leek soup. Ruby said cold soup feels sneaky. Buzz heated his up anyway and yelled, “SOUP SHOULD FEEL WARM ON PURPOSE!”
Lola called vichyssoise “the soup that wears a sweater.” Spike explained it’s just chilled potato-leek soup. Ruby said cold soup feels sneaky. Buzz heated his up anyway and yelled, “SOUP SHOULD FEEL WARM ON PURPOSE!”
November 18, 2025 at 1:13 PM
Happy National Vichyssoise Day!
Lola called vichyssoise “the soup that wears a sweater.” Spike explained it’s just chilled potato-leek soup. Ruby said cold soup feels sneaky. Buzz heated his up anyway and yelled, “SOUP SHOULD FEEL WARM ON PURPOSE!”
Lola called vichyssoise “the soup that wears a sweater.” Spike explained it’s just chilled potato-leek soup. Ruby said cold soup feels sneaky. Buzz heated his up anyway and yelled, “SOUP SHOULD FEEL WARM ON PURPOSE!”
Spike tried to explain why we level off dry ingredients. Buzz tried to karate-chop the excess flour. Ruby whispered, “Chaos dust…” as it floated everywhere.
November 18, 2025 at 1:09 PM
Spike tried to explain why we level off dry ingredients. Buzz tried to karate-chop the excess flour. Ruby whispered, “Chaos dust…” as it floated everywhere.
According to DownDetector.com, which tracks internet outages, the problems began around 6 a.m. Eastern. X (formerly Twitter), Letterboxd, League of Legends and ChatGPT-maker OpenAI all saw a spike in errors over the next hour.
www.techradar.com/pro/live/a-c...
www.techradar.com/pro/live/a-c...
Status overview
DownDetector.com
November 18, 2025 at 1:06 PM
According to DownDetector.com, which tracks internet outages, the problems began around 6 a.m. Eastern. X (formerly Twitter), Letterboxd, League of Legends and ChatGPT-maker OpenAI all saw a spike in errors over the next hour.
www.techradar.com/pro/live/a-c...
www.techradar.com/pro/live/a-c...
I put in alt text also, but major spike in cycling came in 2014 - when the congestion charge went up from £10 to £11.50 and first major cycle tracks were being worked on in central London. Absolutely mad to think that in entire time of mini-Hollands, pandemic etc. dial has really shifted only a bit.
November 18, 2025 at 1:01 PM
I put in alt text also, but major spike in cycling came in 2014 - when the congestion charge went up from £10 to £11.50 and first major cycle tracks were being worked on in central London. Absolutely mad to think that in entire time of mini-Hollands, pandemic etc. dial has really shifted only a bit.
6 Nations Where Tourist Prices Spiked Sharply, Data Shows
https://www.newsbeep.com/nz/141186/
Travel isn’t getting any cheaper—and in some places, the spike is impossible to ignore. Fresh global data…
https://www.newsbeep.com/nz/141186/
Travel isn’t getting any cheaper—and in some places, the spike is impossible to ignore. Fresh global data…
6 Nations Where Tourist Prices Spiked Sharply, Data Shows - New Zealand News Beep
www.newsbeep.com
November 18, 2025 at 1:01 PM
6 Nations Where Tourist Prices Spiked Sharply, Data Shows
https://www.newsbeep.com/nz/141186/
Travel isn’t getting any cheaper—and in some places, the spike is impossible to ignore. Fresh global data…
https://www.newsbeep.com/nz/141186/
Travel isn’t getting any cheaper—and in some places, the spike is impossible to ignore. Fresh global data…
X had a massive outage at 6am and is still out I think.
November 18, 2025 at 12:56 PM
X had a massive outage at 6am and is still out I think.
This is the biggest art I've done!, and I'm very happy with it! What do you think? :3 🐉💜
I've posted all the steps of working on this drawing here patreon.com/8404052/join
#wingsoffire #icewing #sanding #qinter #qibli #winter #spike #spikedragon #americandragon #jakelong #jake_long #spyro
I've posted all the steps of working on this drawing here patreon.com/8404052/join
#wingsoffire #icewing #sanding #qinter #qibli #winter #spike #spikedragon #americandragon #jakelong #jake_long #spyro
November 18, 2025 at 12:50 PM
This is the biggest art I've done!, and I'm very happy with it! What do you think? :3 🐉💜
I've posted all the steps of working on this drawing here patreon.com/8404052/join
#wingsoffire #icewing #sanding #qinter #qibli #winter #spike #spikedragon #americandragon #jakelong #jake_long #spyro
I've posted all the steps of working on this drawing here patreon.com/8404052/join
#wingsoffire #icewing #sanding #qinter #qibli #winter #spike #spikedragon #americandragon #jakelong #jake_long #spyro
A spike in FIP, wOBA, and xwOBA in 2025 complicates the left-hander’s bid for a long-term deal. #cubs #chicago #behereforit
Age Concerns, Statistical Decline, & Groundballs: Evaluating Framber Valdez’s Free Agent Market
A spike in FIP, wOBA, and xwOBA in 2025 complicates the left-hander’s bid for a long-term deal.
dlvr.it
November 18, 2025 at 12:49 PM
A spike in FIP, wOBA, and xwOBA in 2025 complicates the left-hander’s bid for a long-term deal. #cubs #chicago #behereforit
I haven't checked yet, but I would expect a pulse as all the runoff and yuck passes through. We have N sensors here too and they showed a spike as the flood passed. I'll be interested to see how long your P takes to subside!
November 18, 2025 at 12:49 PM
I haven't checked yet, but I would expect a pulse as all the runoff and yuck passes through. We have N sensors here too and they showed a spike as the flood passed. I'll be interested to see how long your P takes to subside!
I was kidding, Spike. 😂
November 18, 2025 at 12:45 PM
I was kidding, Spike. 😂
bolando arte pra carimbar os pacotinhos dos produtos ✨
November 18, 2025 at 12:45 PM
bolando arte pra carimbar os pacotinhos dos produtos ✨
Hello Traders!
📉Stocks🔻Extend Slide, Cloudfare outage roils internet
🇺🇸USD⬆️mostly firmer but Oct jobless claims spike, weekly ADP due today
🇯🇵JPY 🔻drops to fresh 9 mo lows on fiscal concerns, verbal intervention escalates
🇪🇺EUR🔻on risk off flows
🇨🇦CAD⬆️ leads gains today
🇦🇺AUD⬆️ but RBA minutes so willing
📉Stocks🔻Extend Slide, Cloudfare outage roils internet
🇺🇸USD⬆️mostly firmer but Oct jobless claims spike, weekly ADP due today
🇯🇵JPY 🔻drops to fresh 9 mo lows on fiscal concerns, verbal intervention escalates
🇪🇺EUR🔻on risk off flows
🇨🇦CAD⬆️ leads gains today
🇦🇺AUD⬆️ but RBA minutes so willing
November 18, 2025 at 12:35 PM
Hello Traders!
📉Stocks🔻Extend Slide, Cloudfare outage roils internet
🇺🇸USD⬆️mostly firmer but Oct jobless claims spike, weekly ADP due today
🇯🇵JPY 🔻drops to fresh 9 mo lows on fiscal concerns, verbal intervention escalates
🇪🇺EUR🔻on risk off flows
🇨🇦CAD⬆️ leads gains today
🇦🇺AUD⬆️ but RBA minutes so willing
📉Stocks🔻Extend Slide, Cloudfare outage roils internet
🇺🇸USD⬆️mostly firmer but Oct jobless claims spike, weekly ADP due today
🇯🇵JPY 🔻drops to fresh 9 mo lows on fiscal concerns, verbal intervention escalates
🇪🇺EUR🔻on risk off flows
🇨🇦CAD⬆️ leads gains today
🇦🇺AUD⬆️ but RBA minutes so willing
Jeg tjekkede også lige - har ingen problemer nogen steder.. Jeg så der var en spike.. men det var så det..
November 18, 2025 at 12:33 PM
Jeg tjekkede også lige - har ingen problemer nogen steder.. Jeg så der var en spike.. men det var så det..
However, in order to allow fusion and infection, big rearrangements of the Spike protein are needed, so it makes sense that the opposite face is also essential for viral entry.
That might be why Spike TMD is the only fully-conserved TMD across all SARS-CoV-2 VOCs...
That might be why Spike TMD is the only fully-conserved TMD across all SARS-CoV-2 VOCs...
November 18, 2025 at 12:33 PM
However, in order to allow fusion and infection, big rearrangements of the Spike protein are needed, so it makes sense that the opposite face is also essential for viral entry.
That might be why Spike TMD is the only fully-conserved TMD across all SARS-CoV-2 VOCs...
That might be why Spike TMD is the only fully-conserved TMD across all SARS-CoV-2 VOCs...
Another controversy that existed was if the TMD can oligomerize by itself thus aiding Spike trimerization, since there are no structures of full-length pre-fusion Spike.
We showed that it does, and the only way to disrupt the oligomer is to disrupt the GxxAG motif.
We showed that it does, and the only way to disrupt the oligomer is to disrupt the GxxAG motif.
November 18, 2025 at 12:33 PM
Another controversy that existed was if the TMD can oligomerize by itself thus aiding Spike trimerization, since there are no structures of full-length pre-fusion Spike.
We showed that it does, and the only way to disrupt the oligomer is to disrupt the GxxAG motif.
We showed that it does, and the only way to disrupt the oligomer is to disrupt the GxxAG motif.
As for viral entry, scrambling the TMD sequence completely disrupted Spike cell-cell fusion activity...
and mutating the AG from the GxxAG motif also did! This residues might be playing an essential role in fusing the viral and host membranes, but how?
and mutating the AG from the GxxAG motif also did! This residues might be playing an essential role in fusing the viral and host membranes, but how?
November 18, 2025 at 12:33 PM
As for viral entry, scrambling the TMD sequence completely disrupted Spike cell-cell fusion activity...
and mutating the AG from the GxxAG motif also did! This residues might be playing an essential role in fusing the viral and host membranes, but how?
and mutating the AG from the GxxAG motif also did! This residues might be playing an essential role in fusing the viral and host membranes, but how?
It was shocking to see how almost any change that you apply to this region abolishes viral entry of Spike-pseudotyped VSV particles.
Any whole-turn scan and insertion on the N-terminal and core regions of the TMD blocked infectivity, implying essential structural motifs within the helix.
Any whole-turn scan and insertion on the N-terminal and core regions of the TMD blocked infectivity, implying essential structural motifs within the helix.
November 18, 2025 at 12:33 PM
It was shocking to see how almost any change that you apply to this region abolishes viral entry of Spike-pseudotyped VSV particles.
Any whole-turn scan and insertion on the N-terminal and core regions of the TMD blocked infectivity, implying essential structural motifs within the helix.
Any whole-turn scan and insertion on the N-terminal and core regions of the TMD blocked infectivity, implying essential structural motifs within the helix.