Sonogenetics is an emerging field, which aims to control cell functions via acoustic waves.
Here it was shown that protein function could be controlled by applying ultrasound. To achieve this, autocatalytic protein splicing was used.
doi.org/10.1021/jacs...
#iGEM2026#SynBio#biochemistry
Here it was shown that protein function could be controlled by applying ultrasound. To achieve this, autocatalytic protein splicing was used.
doi.org/10.1021/jacs...
#iGEM2026#SynBio#biochemistry
Ultrasonic Control of Protein Splicing by Split Inteins
Utilizing ultrasound as an external stimulus to remotely modulate the activity of proteins is an important aspect of sonopharmacology and establishes the basis for the emerging field of sonogenetics. ...
doi.org
October 13, 2025 at 5:36 AM
Sonogenetics is an emerging field, which aims to control cell functions via acoustic waves.
Here it was shown that protein function could be controlled by applying ultrasound. To achieve this, autocatalytic protein splicing was used.
doi.org/10.1021/jacs...
#iGEM2026#SynBio#biochemistry
Here it was shown that protein function could be controlled by applying ultrasound. To achieve this, autocatalytic protein splicing was used.
doi.org/10.1021/jacs...
#iGEM2026#SynBio#biochemistry
🧪 This Neurotech Reports article on sonogenetics and Merge Labs is free to read: www.neurotechreports.com/pages/sonoge...
#neurotech #neuroscience
#neurotech #neuroscience
Merge Labs, Sam Altman, genetic targeting, ultrasound systems, Open AI, mechanosensitive channels
www.neurotechreports.com
October 1, 2025 at 1:39 AM
🧪 This Neurotech Reports article on sonogenetics and Merge Labs is free to read: www.neurotechreports.com/pages/sonoge...
#neurotech #neuroscience
#neurotech #neuroscience
🧪 Sonogenetics = gene therapy + ultrasound.
I interviewed @logantcollins.bsky.social on the nuances of this technique.
Merge Labs may be first to try.
Will it work?
Let’s see what emerges from Merge.
🧠 Neurotech Reports article link in comments.
#neurotech #neuroscience
I interviewed @logantcollins.bsky.social on the nuances of this technique.
Merge Labs may be first to try.
Will it work?
Let’s see what emerges from Merge.
🧠 Neurotech Reports article link in comments.
#neurotech #neuroscience
October 1, 2025 at 1:39 AM
🧪 Sonogenetics = gene therapy + ultrasound.
I interviewed @logantcollins.bsky.social on the nuances of this technique.
Merge Labs may be first to try.
Will it work?
Let’s see what emerges from Merge.
🧠 Neurotech Reports article link in comments.
#neurotech #neuroscience
I interviewed @logantcollins.bsky.social on the nuances of this technique.
Merge Labs may be first to try.
Will it work?
Let’s see what emerges from Merge.
🧠 Neurotech Reports article link in comments.
#neurotech #neuroscience
To make human brains more amenable to computer chip implants researchers will try using gene therapy to sensitize neurons with ultrasounds in an approach called sonogenetics.
www.extremetech.com/science/gene...
www.extremetech.com/science/gene...
Gene Therapy Could Let Future Implants Control the Brain Via Ultrasound
One of Sam Altman’s pet projects aims to engineer the brain to better work with brain-computer interface implants.
www.extremetech.com
August 22, 2025 at 5:00 PM
To make human brains more amenable to computer chip implants researchers will try using gene therapy to sensitize neurons with ultrasounds in an approach called sonogenetics.
www.extremetech.com/science/gene...
www.extremetech.com/science/gene...
Sam Altman just got into BCI by backing Merge Labs 🧠
- Valued at $850M after a $250M raise
- Developing high-performance, non-invasive brain-computer interfaces
- Their bet: focused ultrasound + neuronal gene editing (sonogenetics)
#neuroskyence #neuropapers #openAI #BCI
- Valued at $850M after a $250M raise
- Developing high-performance, non-invasive brain-computer interfaces
- Their bet: focused ultrasound + neuronal gene editing (sonogenetics)
#neuroskyence #neuropapers #openAI #BCI
Sam Altman’s new startup wants to merge machines and humans
Merge Labs is a new Neuralink rival developing brain-computer interfaces.
www.theverge.com
August 18, 2025 at 1:26 PM
Sam Altman just got into BCI by backing Merge Labs 🧠
- Valued at $850M after a $250M raise
- Developing high-performance, non-invasive brain-computer interfaces
- Their bet: focused ultrasound + neuronal gene editing (sonogenetics)
#neuroskyence #neuropapers #openAI #BCI
- Valued at $850M after a $250M raise
- Developing high-performance, non-invasive brain-computer interfaces
- Their bet: focused ultrasound + neuronal gene editing (sonogenetics)
#neuroskyence #neuropapers #openAI #BCI
If these goons were serious about animal welfare they’d be dumping billions into emerging noninvasive methods like functional ultrasound imaging, better DREADDs, maybe sonogenetics or magnetogenetics. But what they actually want is an excuse to axe half of our science to fund more bombs and cops
July 15, 2025 at 11:56 PM
If these goons were serious about animal welfare they’d be dumping billions into emerging noninvasive methods like functional ultrasound imaging, better DREADDs, maybe sonogenetics or magnetogenetics. But what they actually want is an excuse to axe half of our science to fund more bombs and cops
This review on #sonogenetics discusses the properties of ultrasound waves, ultrasound-sensitive proteins used in sonogenetics, and its potential in managing conditions like #NeurologicalDisorders, #cancer, & ophthalmic diseases, & in #StemCellTherapy. #medsky
#OpenAccess: www.sciencedirect.co...
#OpenAccess: www.sciencedirect.co...
April 14, 2025 at 2:00 PM
This review on #sonogenetics discusses the properties of ultrasound waves, ultrasound-sensitive proteins used in sonogenetics, and its potential in managing conditions like #NeurologicalDisorders, #cancer, & ophthalmic diseases, & in #StemCellTherapy. #medsky
#OpenAccess: www.sciencedirect.co...
#OpenAccess: www.sciencedirect.co...
✨ Physical cues like light and ultrasound enable precise, non-invasive gene circuit control.
👁️ Optogenetics offers high spatiotemporal resolution, while sonogenetics uses ultrasound to activate cellular responses deep within tissues. 🔊
2/5
👁️ Optogenetics offers high spatiotemporal resolution, while sonogenetics uses ultrasound to activate cellular responses deep within tissues. 🔊
2/5
January 11, 2025 at 7:00 AM
✨ Physical cues like light and ultrasound enable precise, non-invasive gene circuit control.
👁️ Optogenetics offers high spatiotemporal resolution, while sonogenetics uses ultrasound to activate cellular responses deep within tissues. 🔊
2/5
👁️ Optogenetics offers high spatiotemporal resolution, while sonogenetics uses ultrasound to activate cellular responses deep within tissues. 🔊
2/5
What do sonogenetics and magnetogenetics look like?
November 19, 2024 at 3:23 PM
What do sonogenetics and magnetogenetics look like?
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics. @biorxivpreprint. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8t1d
www.biorxiv.org
October 30, 2024 at 7:58 AM
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics. @biorxivpreprint. Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8t1d
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics https://www.biorxiv.org/content/10.1101/2024.10.16.618766v1
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics https://www.biorxiv.org/content/10.1101/2024.10.16.618766v1
Sonogenetics offers non-invasive and cell-type specific modulation of cells genetically engineered t
www.biorxiv.org
October 18, 2024 at 12:49 PM
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics https://www.biorxiv.org/content/10.1101/2024.10.16.618766v1
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics https://www.biorxiv.org/content/10.1101/2024.10.16.618766v1
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics https://www.biorxiv.org/content/10.1101/2024.10.16.618766v1
Sonogenetics offers non-invasive and cell-type specific modulation of cells genetically engineered t
www.biorxiv.org
October 18, 2024 at 12:49 PM
Human TRPV4 engineering yields an ultrasound-sensitive actuator for sonogenetics https://www.biorxiv.org/content/10.1101/2024.10.16.618766v1
And that’s a wrap:
#optodbs2024 comes to a close! Mark your 📆: The next one will be June 10-12 2026.
This time we saw cutting edge fiber optic guidance, sonogenetics, targeted drug delivery, and of course a lot of closed loop DBS & Optogenetics. What will we see in 2 years? 👏
#optodbs2024 comes to a close! Mark your 📆: The next one will be June 10-12 2026.
This time we saw cutting edge fiber optic guidance, sonogenetics, targeted drug delivery, and of course a lot of closed loop DBS & Optogenetics. What will we see in 2 years? 👏
November 22, 2024 at 12:00 PM
And that’s a wrap:
#optodbs2024 comes to a close! Mark your 📆: The next one will be June 10-12 2026.
This time we saw cutting edge fiber optic guidance, sonogenetics, targeted drug delivery, and of course a lot of closed loop DBS & Optogenetics. What will we see in 2 years? 👏
#optodbs2024 comes to a close! Mark your 📆: The next one will be June 10-12 2026.
This time we saw cutting edge fiber optic guidance, sonogenetics, targeted drug delivery, and of course a lot of closed loop DBS & Optogenetics. What will we see in 2 years? 👏
Future concept: open BBB with FUS, transfect the region to express more mechanoreceptors (sonogenetics). Then use FUS to modulate the area. 🤯
November 22, 2024 at 1:45 PM
Future concept: open BBB with FUS, transfect the region to express more mechanoreceptors (sonogenetics). Then use FUS to modulate the area. 🤯
Problem with invasive arrays (such as Utah A) on cortex is that cortex moves and over time this hurts cortex drastically. Sonogenetics has temporal and spatial resolution to go contactless!
November 22, 2024 at 1:36 PM
Problem with invasive arrays (such as Utah A) on cortex is that cortex moves and over time this hurts cortex drastically. Sonogenetics has temporal and spatial resolution to go contactless!
Super fascinating talk about Optogenetics (including in humans!) and sonogenetics to restore vision by Serge Picault at #optodbs2024
November 22, 2024 at 1:28 PM
Super fascinating talk about Optogenetics (including in humans!) and sonogenetics to restore vision by Serge Picault at #optodbs2024
Would you be terribly surprised to learn that this person hangs out in the Jordan Peterson subreddit?
May 16, 2024 at 5:10 PM
Would you be terribly surprised to learn that this person hangs out in the Jordan Peterson subreddit?
Will sonogenetics one day replace invasive deep brain stimulation @DBSThinkTank Cool video and new paper out in nature communications! https://doi.org/10.1038/ncomms9264 by @salkinstitute https://www.youtube.com/watch?v=tNnRd0JfT4o @leaddbs
Sonogenetics is a non-invasive approach to activating neu...
Common optogenetic approaches require surgical procedures...
doi.org
December 1, 2024 at 9:47 PM
Will sonogenetics one day replace invasive deep brain stimulation @DBSThinkTank Cool video and new paper out in nature communications! https://doi.org/10.1038/ncomms9264 by @salkinstitute https://www.youtube.com/watch?v=tNnRd0JfT4o @leaddbs
In a first for "sonogenetics", researchers control mammalian cells with sound (i.e. ultrasound) https://www.salk.edu/news-release/in-a-first-for-sonogenetics-researchers-control-mammalian-cells-with-sound/ "activate human cells in a dish and brain cells inside living mice"
In a first for “sonogenetics,” researchers control mammal...
LA JOLLA—Salk scientists have engineered mammalian cells ...
www.salk.edu
April 7, 2025 at 12:26 AM
In a first for "sonogenetics", researchers control mammalian cells with sound (i.e. ultrasound) https://www.salk.edu/news-release/in-a-first-for-sonogenetics-researchers-control-mammalian-cells-with-sound/ "activate human cells in a dish and brain cells inside living mice"
Note that all of these approaches with electrodes, optogenetics or sonogenetics activating primary visual cortex assume that imposing activation can give meaningful pictorial vision; this is unproven and need not hold up if doing so disrupts the error signal in predictive coding
April 7, 2025 at 1:55 AM
Note that all of these approaches with electrodes, optogenetics or sonogenetics activating primary visual cortex assume that imposing activation can give meaningful pictorial vision; this is unproven and need not hold up if doing so disrupts the error signal in predictive coding
Sonogenetics: Using Sound waves to manipulate neurons. Going places in the brain where Optogenetics have not. Beam us up Scotty.@SfNtweets
ow.ly/ZrC830h0thj
ow.ly/ZrC830h0thj
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December 5, 2024 at 6:44 AM
Sonogenetics: Using Sound waves to manipulate neurons. Going places in the brain where Optogenetics have not. Beam us up Scotty.@SfNtweets
ow.ly/ZrC830h0thj
ow.ly/ZrC830h0thj
'#Sonogenetics' allows brain cells to be controlled by sound waves http://www.theguardian.com/science/2015/sep/15/sonogenetics-allows-brain-cells-to-be-controlled-by-sound-waves
'Sonogenetics' allows brain cells to be controlled by sou...
Scientists have used genetically modified worms to show t...
www.theguardian.com
April 12, 2025 at 3:20 AM
'#Sonogenetics' allows brain cells to be controlled by sound waves http://www.theguardian.com/science/2015/sep/15/sonogenetics-allows-brain-cells-to-be-controlled-by-sound-waves