November 24, 2024 at 9:43 AM
Shorter is better table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky #medsky #tbsky
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky #medsky #tbsky
🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
November 21, 2024 at 2:56 PM
Shorter is better table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky #medsky #tbsky
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky #medsky #tbsky
Not a RCT, but more evidence for #Shorterisbetter in GAS pharyngitis. @bradspellberg.bsky.social
Effect of a widespread reduction in treatment duration for group A streptococcal pharyngitis on outcomes including household transmission
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Effect of a widespread reduction in treatment duration for group A streptococcal pharyngitis on outcomes including household transmission
Shorter-course treatment for group A streptococcal pharyngitis may be equivalent to ten-days for clinical cure but effectiveness for pharyngeal GAS eradication is uncertain.
doi.org
June 9, 2025 at 4:35 PM
Not a RCT, but more evidence for #Shorterisbetter in GAS pharyngitis. @bradspellberg.bsky.social
Good question for the next #UTI #guidelines or meanwhile for dedicated studies... Now the focus is on #ShorterIsBetter but the topic of modifying doses over the #antibiotic course in case of improvement according to primary infection site/source is still neglected.
July 20, 2025 at 6:56 PM
Good question for the next #UTI #guidelines or meanwhile for dedicated studies... Now the focus is on #ShorterIsBetter but the topic of modifying doses over the #antibiotic course in case of improvement according to primary infection site/source is still neglected.
Cannot thank @drandrekalil.bsky.social enough for inviting me to write this commentary on the BALANCE trial for ACP Journal Club in @annalsofim.bsky.social this month!
#ShorterIsBetter #IDSky @unmc-id.bsky.social
www.acpjournals.org/doi/10.7326/...
#ShorterIsBetter #IDSky @unmc-id.bsky.social
www.acpjournals.org/doi/10.7326/...
March 4, 2025 at 3:44 AM
Cannot thank @drandrekalil.bsky.social enough for inviting me to write this commentary on the BALANCE trial for ACP Journal Club in @annalsofim.bsky.social this month!
#ShorterIsBetter #IDSky @unmc-id.bsky.social
www.acpjournals.org/doi/10.7326/...
#ShorterIsBetter #IDSky @unmc-id.bsky.social
www.acpjournals.org/doi/10.7326/...
#IDSky I updated all-in-one table for #ShorterIsBetter approach based on @bradspellberg.bsky.social original work. All references of mentioned studies in the table are available on: www.bradspellberg.com/shorter-is-b...
PDF document is availabe on demand (send me DM).
PDF document is availabe on demand (send me DM).
February 23, 2025 at 3:48 PM
#IDSky I updated all-in-one table for #ShorterIsBetter approach based on @bradspellberg.bsky.social original work. All references of mentioned studies in the table are available on: www.bradspellberg.com/shorter-is-b...
PDF document is availabe on demand (send me DM).
PDF document is availabe on demand (send me DM).
‼ Excepciones a #Shorterisbetter 👉🏻 Hay situaciones concretas en las que un ciclo "corto" de antibióticos NO es igual de eficaz que uno "largo" (ej. otitis media < 2 años, aspergilosis pulmonar crónica...)
Tabla noviembre 2024 #BradSpellberg
#EAAD #WAAW #AntimicrobialResistance
Tabla noviembre 2024 #BradSpellberg
#EAAD #WAAW #AntimicrobialResistance
November 22, 2024 at 4:15 PM
‼ Excepciones a #Shorterisbetter 👉🏻 Hay situaciones concretas en las que un ciclo "corto" de antibióticos NO es igual de eficaz que uno "largo" (ej. otitis media < 2 años, aspergilosis pulmonar crónica...)
Tabla noviembre 2024 #BradSpellberg
#EAAD #WAAW #AntimicrobialResistance
Tabla noviembre 2024 #BradSpellberg
#EAAD #WAAW #AntimicrobialResistance
Shorter is better table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky ##medsky #tbsky
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky ##medsky #tbsky
🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
November 21, 2024 at 2:28 PM
Shorter is better table is updated
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky ##medsky #tbsky
Wow, 4 RCTs [non S.aureus] bactremia
7d is non inferior to 14d
Spread the word
Credit goes to my friend: Dr.Brad Spellberg #shorterisbetter #idsky ##medsky #tbsky
👍Fantastic study 👀 at whether #shorterisbetter in Neutropenic Bacteremia in adults. >80% GNB with almost 18% MDRO, profound neutropenia in 83% of enrollees & post therapy Abx PPX in 65%. Adequate source control in 70%-100%. No diff in relapse or ☠️ if <10 vs > 10 ABX days. #IDSky #TIDSky
Congratulations to @nischalr3.bsky.social and his team for their paper being selected as the @thetxidjournal.bsky.social 2024 Bob Rubin Clinical Impact Awardee - this award selects the paper felt to have the biggest impact on clinical care in #TxID!
#IDSky
onlinelibrary.wiley.com/doi/10.1111/...
#IDSky
onlinelibrary.wiley.com/doi/10.1111/...
Evaluating antimicrobial duration for Gram‐negative bacteremia in patients with neutropenia due to hematologic malignancy or hematopoietic stem cell transplantation
In the management of immunocompromised patients with neutropenia and Gram-negative bloodstream infection, short antimicrobial courses (≤10 days) had comparable propensity score-adjusted 90-day outcom...
onlinelibrary.wiley.com
November 18, 2024 at 3:53 PM
👍Fantastic study 👀 at whether #shorterisbetter in Neutropenic Bacteremia in adults. >80% GNB with almost 18% MDRO, profound neutropenia in 83% of enrollees & post therapy Abx PPX in 65%. Adequate source control in 70%-100%. No diff in relapse or ☠️ if <10 vs > 10 ABX days. #IDSky #TIDSky
#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
November 19, 2024 at 7:05 PM
#ShorterIsBetter in immunocompromised hosts?
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
Short treatments are feasible in early responders without source control issues.
A significant number of observational studies serve as proof-of-concept on the feasibility of short courses in selected patients (see ⚠️)
#AMSsky #IDOnc #TxID #IDsky
In SHORTEN-2, immunocompromised hosts were not excluded if early clinical response and no unresolved source issues exist at randomization.
We hope to generate actionable data to guide the management of Pseudomonas BSI also in this population! 💪🏼
(🧵3/3) #AMSky #IDsky #TxID #IDOnc #ShorterIsBetter
We hope to generate actionable data to guide the management of Pseudomonas BSI also in this population! 💪🏼
(🧵3/3) #AMSky #IDsky #TxID #IDOnc #ShorterIsBetter
April 29, 2025 at 10:29 PM
In SHORTEN-2, immunocompromised hosts were not excluded if early clinical response and no unresolved source issues exist at randomization.
We hope to generate actionable data to guide the management of Pseudomonas BSI also in this population! 💪🏼
(🧵3/3) #AMSky #IDsky #TxID #IDOnc #ShorterIsBetter
We hope to generate actionable data to guide the management of Pseudomonas BSI also in this population! 💪🏼
(🧵3/3) #AMSky #IDsky #TxID #IDOnc #ShorterIsBetter
Only 58 patients to go!
Recruitment is moving along as planned, and fingers crossed, we’ll be done before summer.
Huge shoutout to the @shorten2trial.bsky.social team for keeping up the great work!
#AMSsky #IDSky #ShorterIsBetter
Recruitment is moving along as planned, and fingers crossed, we’ll be done before summer.
Huge shoutout to the @shorten2trial.bsky.social team for keeping up the great work!
#AMSsky #IDSky #ShorterIsBetter
December 2, 2024 at 5:34 PM
Only 58 patients to go!
Recruitment is moving along as planned, and fingers crossed, we’ll be done before summer.
Huge shoutout to the @shorten2trial.bsky.social team for keeping up the great work!
#AMSsky #IDSky #ShorterIsBetter
Recruitment is moving along as planned, and fingers crossed, we’ll be done before summer.
Huge shoutout to the @shorten2trial.bsky.social team for keeping up the great work!
#AMSsky #IDSky #ShorterIsBetter
🦠💊Acabamos la #WAAW2024 con la versión actualizada de la tabla #Shorterisbetter de Brad Spellberg (nov 2024)
¡Recuerda! Una pauta "corta" antibióticos es IGUAL de eficaz que "larga"(en gran nº situaciones) y:
⬇️resistencias, efectos adversos, costes
⬆️adherencia
www.bradspellberg.com/shorter-is-b...
¡Recuerda! Una pauta "corta" antibióticos es IGUAL de eficaz que "larga"(en gran nº situaciones) y:
⬇️resistencias, efectos adversos, costes
⬆️adherencia
www.bradspellberg.com/shorter-is-b...
November 22, 2024 at 4:15 PM
🦠💊Acabamos la #WAAW2024 con la versión actualizada de la tabla #Shorterisbetter de Brad Spellberg (nov 2024)
¡Recuerda! Una pauta "corta" antibióticos es IGUAL de eficaz que "larga"(en gran nº situaciones) y:
⬇️resistencias, efectos adversos, costes
⬆️adherencia
www.bradspellberg.com/shorter-is-b...
¡Recuerda! Una pauta "corta" antibióticos es IGUAL de eficaz que "larga"(en gran nº situaciones) y:
⬇️resistencias, efectos adversos, costes
⬆️adherencia
www.bradspellberg.com/shorter-is-b...
🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
November 20, 2024 at 10:18 PM
🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
🦠 Shorter antibiotics (≤5 days) for respiratory infections match longer in effectiveness, to combat AMR, per our UK study of 640 patients @MDPIOpenAcces.
📢 Read: communities.springernature.com/posts/shorte...
🔗 Study: www.mdpi.com/1424-8247/17...
#AMR #AntimicrobialStewardship #ShorterIsBetter
📢 Read: communities.springernature.com/posts/shorte...
🔗 Study: www.mdpi.com/1424-8247/17...
#AMR #AntimicrobialStewardship #ShorterIsBetter
July 7, 2025 at 10:31 AM
🦠 Shorter antibiotics (≤5 days) for respiratory infections match longer in effectiveness, to combat AMR, per our UK study of 640 patients @MDPIOpenAcces.
📢 Read: communities.springernature.com/posts/shorte...
🔗 Study: www.mdpi.com/1424-8247/17...
#AMR #AntimicrobialStewardship #ShorterIsBetter
📢 Read: communities.springernature.com/posts/shorte...
🔗 Study: www.mdpi.com/1424-8247/17...
#AMR #AntimicrobialStewardship #ShorterIsBetter
🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
November 20, 2024 at 10:23 PM
🫁💊 #Shorterisbetter Pauta "corta" vs "larga" en tuberculosis (noviembre 2024)
#EAAD #WAAW #AntimicrobialResistance #KeepAntibioticsWorking
#EAAD #WAAW #AntimicrobialResistance #KeepAntibioticsWorking
November 22, 2024 at 4:15 PM
🫁💊 #Shorterisbetter Pauta "corta" vs "larga" en tuberculosis (noviembre 2024)
#EAAD #WAAW #AntimicrobialResistance #KeepAntibioticsWorking
#EAAD #WAAW #AntimicrobialResistance #KeepAntibioticsWorking
"If you're going to give antibiotics to people who don't need them, at least do us the courtesy of doing it for a brief period of time." 💊🦠 #ShorterIsBetter #AntimicrobialStewardship
Antibiotic stewardship, data, and uncertainty: A conversation with Brad Spellberg
www.cidrap.umn.edu
March 26, 2025 at 11:40 AM
"If you're going to give antibiotics to people who don't need them, at least do us the courtesy of doing it for a brief period of time." 💊🦠 #ShorterIsBetter #AntimicrobialStewardship
With our @shorten2trial.bsky.social RCT we will hopefully provide further specific data on P. aeruginosa BSIs, including those occurring in immunocompromised hosts 🤞🏻
#ShorterIsBetter #PsWatch #AMSsky #IDSky #IDOnc #TxID
#ShorterIsBetter #PsWatch #AMSsky #IDSky #IDOnc #TxID
November 24, 2024 at 4:44 PM
With our @shorten2trial.bsky.social RCT we will hopefully provide further specific data on P. aeruginosa BSIs, including those occurring in immunocompromised hosts 🤞🏻
#ShorterIsBetter #PsWatch #AMSsky #IDSky #IDOnc #TxID
#ShorterIsBetter #PsWatch #AMSsky #IDSky #IDOnc #TxID
This table must be reposted by every physician, every ID and Critical Care clinician, every surgeon, every medical or pharmacy resident or intern, every antibiotic steward.
Please spread the word. Shorter is better! #idsky #medsky ##shorterisbetter
Please spread the word. Shorter is better! #idsky #medsky ##shorterisbetter
🔥Everyone's favorite #shorterisbetter table is updated🔥
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
"BALANCE is now published,
so the table is now updated!
GNB bacteremia is now listed as Bacteremia(non S.aureus)
Neary 5,000 patients have now been randomized to 1 vs. 2 Constantine Units for non S. aureus bacteremia " Dr.Spellberg #idsky
November 20, 2024 at 10:28 PM
This table must be reposted by every physician, every ID and Critical Care clinician, every surgeon, every medical or pharmacy resident or intern, every antibiotic steward.
Please spread the word. Shorter is better! #idsky #medsky ##shorterisbetter
Please spread the word. Shorter is better! #idsky #medsky ##shorterisbetter
Instant follow my dear friend
Welcome to #idsky
@bradspellberg.bsky.social
Wouldn't imagine #idsky without him, his knowledge and wisdom
He's the myths buster
#shorterisbetter
A legend & jedi master for #IDTwitter and everyone #mustfollow him #medsky #AMSsky #utisky #tbsky
Welcome to #idsky
@bradspellberg.bsky.social
Wouldn't imagine #idsky without him, his knowledge and wisdom
He's the myths buster
#shorterisbetter
A legend & jedi master for #IDTwitter and everyone #mustfollow him #medsky #AMSsky #utisky #tbsky
December 1, 2024 at 4:59 AM
Instant follow my dear friend
Welcome to #idsky
@bradspellberg.bsky.social
Wouldn't imagine #idsky without him, his knowledge and wisdom
He's the myths buster
#shorterisbetter
A legend & jedi master for #IDTwitter and everyone #mustfollow him #medsky #AMSsky #utisky #tbsky
Welcome to #idsky
@bradspellberg.bsky.social
Wouldn't imagine #idsky without him, his knowledge and wisdom
He's the myths buster
#shorterisbetter
A legend & jedi master for #IDTwitter and everyone #mustfollow him #medsky #AMSsky #utisky #tbsky
From @drtoddlee.bsky.social @dremilymcd.bsky.social @angelahuttner.bsky.social @josemolinagb.bsky.social et al in @jama.com Network Open:
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
March 23, 2025 at 5:20 PM
From @drtoddlee.bsky.social @dremilymcd.bsky.social @angelahuttner.bsky.social @josemolinagb.bsky.social et al in @jama.com Network Open:
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
It’s really cool to see the #IDSky community light up with discussion of the BALANCE trial results. Yet another brick in the #ShorterIsBetter canon.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early,
appropriate antibiotic therapy is important, but the duration of treatment is uncertain.
In a multicenter, non...
www.nejm.org
November 20, 2024 at 7:28 PM
It’s really cool to see the #IDSky community light up with discussion of the BALANCE trial results. Yet another brick in the #ShorterIsBetter canon.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
#idsky #shorterisbetter outpatient oncology pts w/uncomplicated infections treated for 7d vs 14d for UTI, SSTI and LRTI showed no worse outcomes with shorter duration #idmeded #meded
Is shorter better in oncology patients, too? A retrospective cohort study of short- versus long-course antibiotic therapy for uncomplicated infections in solid tumor patients receiving care in ambulatory oncology clinics
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Is shorter better in oncology patients, too? A retrospective cohort study of short- versus long-course antibiotic therapy for uncomplicated infections in solid tumor patients receiving care
This retrospective cohort study evaluated short- vs. long-course antibiotics for uncomplicated infections in ambulatory solid tumor patients.
bit.ly
August 28, 2025 at 6:56 PM
#idsky #shorterisbetter outpatient oncology pts w/uncomplicated infections treated for 7d vs 14d for UTI, SSTI and LRTI showed no worse outcomes with shorter duration #idmeded #meded
🆕 Just published in NEJM!
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections | NEJM
Bloodstream infections are associated with substantial morbidity and mortality. Early, appropriate antibiotic therapy is important, but the duration of treatment is uncertain. In a multicenter, non...
www.nejm.org
November 20, 2024 at 3:24 PM
🆕 Just published in NEJM!
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter
The BALANCE trial definitively establishes 7-day treatments as the standard of care for uncomplicated BSIs, with more than 3,600 randomized patients.
Fantastic work! @drtoddlee.bsky.social
www.nejm.org/doi/full/10.... #AMSsky #IDSky #ShorterIsBetter