It was a double ribosome talk day for us in Bonn with talks today by Ranen Aviner from @czbiohub.bsky.social and Simon @bekkerjensenlab.bsky.social from BRIC Copenhagen. Simon is visiting for the @rhinelandrna.bsky.social tomorrow and Ranen is a visiting scientist in my and Ina‘s lab. #RNAsky
November 13, 2025 at 4:44 PM
It was a double ribosome talk day for us in Bonn with talks today by Ranen Aviner from @czbiohub.bsky.social and Simon @bekkerjensenlab.bsky.social from BRIC Copenhagen. Simon is visiting for the @rhinelandrna.bsky.social tomorrow and Ranen is a visiting scientist in my and Ina‘s lab. #RNAsky
November 12, 2025 at 10:29 PM
Despair seems like a reasonable course of action
'Some estimates are that up to 20% of the entire proteome can bind RNA and moreover that about 20% of all known protein complexes have an RNA component in them and you really have to think about how to deal with such large figures.'
'Some estimates are that up to 20% of the entire proteome can bind RNA and moreover that about 20% of all known protein complexes have an RNA component in them and you really have to think about how to deal with such large figures.'
RNA and Proteins: Who Bosses Whom?
www.science.org
November 12, 2025 at 1:58 PM
'With the discovery of riboregulation, this puzzling situation recently changed profoundly for some of these non-canonical RBPs (...) This review will build on textbook features of classical RBPs and further aims to broaden the perspective of biologically meaningful RNA-protein interactions.'
Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
The advent of system-wide proteomic approaches has largely expanded the number of
RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming
our understanding of biolog...
www.cell.com
November 12, 2025 at 1:58 PM
If you're in Ghent tomorrow ! I'll be sharing our recent progress deciphering the sRNA-based dominance/recessivity interactions at the self-incompatibility locus in Arabidopsis 🌱
TOMORROW: SEMINAR by @vincentcastric.bsky.social from @univlille.bsky.social @cnrs.fr, invited by @pnovik.bsky.social and @yvdp.bsky.social. @viblifesciences.bsky.social
November 12, 2025 at 10:50 AM
We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky
November 11, 2025 at 3:53 PM
We’ll soon be advertising a postdoc position (3 years) to study how mRNA-specific translational regulation shapes the innate immune system, in collaboration with @alf-castello.bsky.social. The formal ad will be out soon but get in touch if you’d like an informal chat! #RNASky
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
November 11, 2025 at 10:57 AM
Our new special collection "Protein-Nucleic Acid Interactions: From Origins to Design (2025)" is now published in Current Opinion in Structural Biology. I'm excited to have both co-edited it with Shandar Ahmad and contributed a review!
www.sciencedirect.com/special-issu...
www.sciencedirect.com/special-issu...
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
November 11, 2025 at 10:55 AM
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:24 AM
November 10, 2025 at 12:23 AM
Wowwww that's super cool!
#RNAsky
#RNAsky
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Circadian clock control of ribosome composition promotes rhythmic translation and termination fidelity
Lamb et al. show that the circadian clock rhythmically remodels ribosome composition in Neurospora crassa. Clock-regulated incorporation of the ribosomal protein eL31 is required for rhythmic translation and translation fidelity, linking temporal ribosome remodeling to daily changes in proteome diversity.
dlvr.it
November 9, 2025 at 12:48 AM
Wowwww that's super cool!
#RNAsky
#RNAsky
I highly recommend this meeting! 👌 #RNAsky
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
codon usage
About the Conference
Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...
sites.google.com
November 7, 2025 at 6:43 PM
I highly recommend this meeting! 👌 #RNAsky
I am NOT surprised, was sure this could exist.
Beautiful!!!! #RNAsky 🤩🤩🤩
Beautiful!!!! #RNAsky 🤩🤩🤩
wait, wait, what 😱
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases in @science.org
www.science.org/doi/10.1126/...
November 7, 2025 at 8:41 AM
I am NOT surprised, was sure this could exist.
Beautiful!!!! #RNAsky 🤩🤩🤩
Beautiful!!!! #RNAsky 🤩🤩🤩
Next Codon Usage Meeting, May 31st to June 3rd, 2026 in Montreal right after the RNA Society Meeting. The list of speakers will be up soon.
sites.google.com/view/codonus...
sites.google.com/view/codonus...
codon usage
About the Conference
Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...
sites.google.com
November 6, 2025 at 11:16 PM
We just got an ERC synergy to work on our beloved tRNAs and see what nature could tell us!
Very happy and excited to be part of this mission! Congratulations to all the 4 labs!
More in this link: erc.europa.eu/news-events/...
#ERC #synergy_grants #RNA #rnasky
Very happy and excited to be part of this mission! Congratulations to all the 4 labs!
More in this link: erc.europa.eu/news-events/...
#ERC #synergy_grants #RNA #rnasky
November 6, 2025 at 12:27 PM
We just got an ERC synergy to work on our beloved tRNAs and see what nature could tell us!
Very happy and excited to be part of this mission! Congratulations to all the 4 labs!
More in this link: erc.europa.eu/news-events/...
#ERC #synergy_grants #RNA #rnasky
Very happy and excited to be part of this mission! Congratulations to all the 4 labs!
More in this link: erc.europa.eu/news-events/...
#ERC #synergy_grants #RNA #rnasky
And we wrapped up the first edition of #AsiaRNA2025 yesterday - too many awesome talks to post. Thanks everyone for sharing mostly unpublished and rather exciting results. Posting a few highlights 👇
#RNASky
#RNASky
November 6, 2025 at 12:02 PM
And we wrapped up the first edition of #AsiaRNA2025 yesterday - too many awesome talks to post. Thanks everyone for sharing mostly unpublished and rather exciting results. Posting a few highlights 👇
#RNASky
#RNASky
www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 5, 2025 at 6:02 PM
Advice required from ppl who do #CRISPR screens.
I want to do a CRISPRi screen. But, due to the nature of my assay, i can't use pooled sgRNAs. I need to do it individually for each guide.
Any suggestions on how to create such a library easily, cheaply & quickly?
Any company who can make it?
#RNASky
I want to do a CRISPRi screen. But, due to the nature of my assay, i can't use pooled sgRNAs. I need to do it individually for each guide.
Any suggestions on how to create such a library easily, cheaply & quickly?
Any company who can make it?
#RNASky
November 5, 2025 at 5:45 PM
#TEsky #RNAsky A specialized bacterial group II intron is a highly efficient retrotransposon doi.org/10.1186/s131...
A specialized bacterial group II intron is a highly efficient retrotransposon - Mobile DNA
Mobile group II introns are site-specific retrotransposons composed of a large self-splicing ribozyme and an intron-encoded reverse transcriptase that are widespread in bacterial and organellar genome...
doi.org
November 5, 2025 at 3:08 PM
#TEsky #RNAsky A specialized bacterial group II intron is a highly efficient retrotransposon doi.org/10.1186/s131...
Great work from my colleague and neighbor Shuo Gu and his team! #RNAsky #RNAbiology
New online: DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01671-wMalagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger microRNAs, revealing a strand-switch mechanism in tumorigenesis.
go.nature.com
November 4, 2025 at 11:47 AM
Great work from my colleague and neighbor Shuo Gu and his team! #RNAsky #RNAbiology
Our new paper maps the tRNA modification landscape in Vibrio cholerae! 💫
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
The tRNA epitranscriptomic landscape and RNA modification enzymes in Vibrio cholerae
Author summary This study charts the first genome-wide map of transfer RNA (tRNA) modifications in the cholera pathogen, Vibrio cholerae, revealing how chemical marks on tRNAs shape translation and st...
journals.plos.org
November 3, 2025 at 11:58 PM
Our new paper maps the tRNA modification landscape in Vibrio cholerae! 💫
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
We describe differences from E. coli and discuss links to decoding of stress-related codons 🦠
Huge thanks to amazing co-authors and collaborators!
@plos.org #rnasky #microsky #tRNAmodifications
Interesting!
#RNASky
#RNASky
And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!
Pseudouridine selects RNAs for extracellular transport
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using geno...
www.biorxiv.org
November 2, 2025 at 8:11 PM
Interesting!
#RNASky
#RNASky
November 1, 2025 at 10:39 PM