#randomizedtrials
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f2harrell.bsky.social
The necessity of analyzing parallel group randomized studies by actually comparing the parallel groups needs to be hammered home. I’m so glad to see this letter @statsepi.bsky.social #statistics #rct #randomizedtrials
statsepi.bsky.social Darren Dahly @statsepi.bsky.social · Oct 2
Sincere kudos to the editors of the American Journal of Gastroenterology for publishing our letter (with @timpmorris.bsky.social).

journals.lww.com/ajg/citation...
October 2, 2024 at 1:02 PM
jameslindlibrary.bsky.social
Ahoy! You might also be interested in reading the piece Dave Sackett wrote for me about why he became a clinician trialist. It's available free here: www.jameslindlibrary.org/articles/why...
#RandomizedTrials #DaveSackett #EBM
Why did I become a clinician-trialist? - The James Lind Library
The seeds of iconoclasm In 1956 I went to the University of Illinois College of Medicine to be taught how to become a physician. Despite the College’s well-deserved reputation, a ...
www.jameslindlibrary.org
September 9, 2025 at 8:38 AM
jameslindlibrary.bsky.social
Ahoy! You might also be interested in reading the piece Dave Sackett wrote for me about why he became a clinician trialist. It's available free here: www.jameslindlibrary.org/articles/why...
#RandomizedTrials #DaveSackett #EBM
September 9, 2025 at 8:42 AM
miguelhernan.org
In Chapter 10 of "Causal Inference: What If", we describe arguments for adjustment in randomized trials and refute some fallacies used to advise against adjustment.
www.hsph.harvard.edu/miguel-herna...

A practical challenge is how to incorporate adjustment into the design of #randomizedtrials.
November 26, 2024 at 1:38 PM
trialschangelives.bsky.social
This week's reading and learning: Dave Sackett's essay from 25 years ago on why not gaining "coal-face" commitment and not using the uncertainty principle can lead to the failure of randomised trials
www.cmaj.ca/content/162/... #ReadAboutTrials
#RCT #EBHC #EBM #RandomizedTrials
@cmaj.ca
Why randomized controlled trials fail but needn't: 1. Failure to gain "coal-face" commitment and to use the uncertainty principle
From the undersideMy pager went off as I was half-dozing, half-reading the newspaper. Yuri Gagarin, born the same year as me, had just become the first man to orbit the earth; Nelson Mandela, not yet ...
www.cmaj.ca
September 8, 2025 at 3:20 PM
thaithanhnha.bsky.social
CONSORT 2025 statement: updated guideline for reporting randomized trials.

www.nature.com/articles/s41...

@natmedicine.bsky.social
#CardioSky #MedSky #RandomizedTrials
April 19, 2025 at 1:04 PM
trialschangelives.bsky.social
#CochraneDaily Just published! Study of 50 Cochrane reviews found that only one quarter (109 of 423) of the included trials which examined the primary outcome had been pre-registered www.jclinepi.com/article/S089...
#Cochrane
#RCT #RandomizedTrials
@jclinepi.bsky.social
Patterns of pre-registration and publication of trials in Cochrane systematic reviews of interventions
It is widely recognised that selective reporting clinical trial results based on their outcomes, in the forms of publication bias, outcome reporting bias, or p-hacking, has detrimental effects on the ...
www.jclinepi.com
September 5, 2025 at 10:54 AM
denismongin.bsky.social
Do people register their #randomizedtrials before starting it ?
We studied more than 1000 RCT in #rheumatology to answer this question, to see how it evolved in time and how it varied between RCTs⬇️

Just published in @jclinepi.bsky.social :
jclinepi.com/article/S089...

#Metaresearch #EpiSky
Prospective registration of trials: where we are, why, and how we could get better
Transparent trial conduct requires prospective registration of a randomized controlled clinical trial (RCT) before the enrollment of the first participant. We aimed to (1) estimate the proportion of R...
jclinepi.com
November 26, 2024 at 2:02 PM
trialschangelives.bsky.social
#WordsOfToday "Would trying to solve the puzzle of designing a study to solve the puzzle of whether people solving puzzles is good for the brain, help solve the puzzle?" Oko Dus, 2020

#Puzzle #Sudoku #Crossword
#RandomizedTrials #RCT
#WhoseTrialIsItAnyway?
#QuotesDaily
September 26, 2025 at 10:51 AM
denismongin.bsky.social
Women’s authorship in RCTs: how much, how is it evolving?

We analyzed the gender of authors in all #randomizedtrials in #rheumatology since 2009.

Short answer: Not great, and not improving.

Just published in RMD Open: doi.org/10.1136/rmdo...

Some details below ⬇️ 1/5
#Metaresearch #EpiSky
Trends and influences in women authorship in randomised controlled trials in rheumatology: a comprehensive analysis of all published RCTs from 2009 to 2023
Objectives We examined the evolution and influencing factors of women’s authorship in randomised controlled trials (RCTs) published in rheumatology. Methods We analysed all RCTs published in rheumato...
rmdopen.bmj.com
March 31, 2025 at 8:38 AM