Using #InVivo #VolumeImaging, we found #age related #vascular changes:
• ↑ #Tortuosity of #PenetratingArterioles
• ↓ #Arteriolar-capillary density
• ↑ #Capillaries at the venous end + #aneurysm-like bulbs downstream of #PrecapillarySphincters.

By recording #cortical #angiograms during i.v. injection of FITC-dextran 🟢 in #adult and #old #NG2DsRed mice, we time-colored the #arterioles 🔴 and #venules 🔵. We found that #OldMice have less #collaterals and more #tortuous #PenetratingArterioles.

Did you know that #neuronal #processes arrange perpendicular to #vascular direction around #penetratingarterioles and arterial end #capillaries? 🤔 I have speculated that this may enhance #neurovascularcoupling. Here I show examples in the #human #brain. 🧠 vb.bioscientifica.com/view/journal...