CEPI, Serum Institute of India and the University of Oxford collaborate to manufacture ChAdOx1 NipahB vaccines for Phase II trials and

Where Science Meets Security

Nipah virus continues to loom as one of the most potent viral threats to human health, but India’s focused pursuit of monoclonal

The Indian Council of Medical Research (ICMR) has invited Expressions of Interest (EoI) from eligible organisations, companies, and manufacturers for the development and production of monoclonal antibodies (mAbs) against Nipah viral disease. Nipah virus (NiV) has emerged as a major...

The Indian Council of Medical Research (ICMR) has invited Expressions of Interest (EoI) from eligible organisations, companies, and manufacturers for the

The Indian Council of Medical Research (ICMR) has invited Expressions of Interest (EoI) from eligible organisations, companies, and manufacturers for the

(Vax-Before-Travel News)

AbstractNipah virus (NiV) comprises two strains, Malaysia and Bangladesh, associated with severe respiratory and/or neurological disease in humans. Experimentally infected Syrian hamsters demonstrate the full spectrum of clinical signs reported in humans, serving as valuable pre-clinical screening models for NiV disease. Medical countermeasure development relies on well-characterized disease models to understand disease progression, guiding pre-clinical and clinical trial design. Variability in NiV-disease presentation and outcome necessitates large group sizes in animal model natural history studies. To advance the use of hamsters in NiV pre-clinical studies, we analysed in-house data from 19 independent studies comprising over 500 hamsters intranasally or intraperitoneally infected with NiV-Malaysia or NiV-Bangladesh. We demonstrate strain- and route-associated differences in clinical course, lethality, and viral loads, presenting cohort and individual data. These analyses provide key data to guide experimental design for pathogenesis, pathophysiology, and medical countermeasure studies.

Alt: a girl with purple hair is standing in front of a calendar that says 1983

Antiviral prescribing for children with increased risk for severe influenza declined during the COVID-19 pandemic compared with the prepandemic period, despite unchanged treatment guidelines, researchers reported last week in JAMA Network Open. For the study, a team led by researchers...

In September cholera cases were down 27% from August.