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arkanalabs.bsky.social
(1/3) The patient is a 76-year-old man with numerous complaints including weakness, myalgia, arthralgia, back pain radiating down bilateral legs, cramps and twitching, imbalance, speech disorder, difficulty walking, and numbness.

#NeuroNotes #neuropath #pathology #neuromuscularpath
July 22, 2025 at 1:05 PM
arkanalabs.bsky.social

What is your diagnosis based on the provided frozen section H&E, modified Gomori Trichrome, esterase and myosin heavy chain fast (MHCf)?

#NeuroNotes #neuromuscular #neuropath
December 17, 2024 at 4:54 PM
arkanalabs.bsky.social
The patient is a 92-year-old-male and presented progressive muscle weakness that began in the left upper extremity and spread to the BLEs and bulbar muscles. CK WNL. EMG/NCS: widespread denervation and reinnervation.

Based on the images below what is the most likely etiology? #NeuroNotes #pathsky
September 24, 2025 at 1:03 PM
arkanalabs.bsky.social
What is the likely diagnosis based on the info in this thread?

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
November 26, 2024 at 2:59 PM
arkanalabs.bsky.social
(1/2) The patient is a 62-year-old woman with asthma, GERD, moderate alcohol intake, and hypertension who presents with 4 weeks of weakness, arthralgia, and fatigue. Her family history is significant for breast cancer and alcohol abuse.

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
January 27, 2025 at 2:22 PM
arkanalabs.bsky.social
Which genetic test is required to establish the diagnosis in this 59-year-old with distal muscle weakness, mild myotonia, and persistently elevated CPK values (200-300 U/L)?

#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
September 29, 2025 at 1:15 PM
arkanalabs.bsky.social
The answer is: Collagen pockets

To learn more, head to our blog: www.arkanalabs.com/collagen-poc...

#neuropath #neuromuscular #neuronotes #pathology
Collagen Pockets in Nerve Biopsy
When small unmyelinated axons are lost to damage, collagen pockets in nerve biopsies are one morphologic sign of axonal loss.
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November 4, 2025 at 2:53 PM
arkanalabs.bsky.social
This previously healthy 35-year-old patient presented with proximal upper and lower extremity weakness and myalgias. Laboratory studies showed normal CPK. The patient's home medication is negative for myotoxic medications.

#NeuroNotes #neuropath #pathology #neuromuscularpath
August 26, 2025 at 12:55 PM
arkanalabs.bsky.social
1/ Last we we showed a 62-year-old man with sudden onset of progressive anesthesia and dysesthesia in hands & feet, and left foot drop. Today we're doing a follow-up of that case.

Last week's post: https://buff.ly/4fUjYGv

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
Arkana Labs (@arkanalabs.bsky.social)
(1/3) The patient is a 62-year-old man with sudden onset of progressive anesthesia and dysesthesia in hands & feet, and left foot drop. His current medications are atorvastatin, gabapentin,…
bsky.app
January 13, 2025 at 2:15 PM
arkanalabs.bsky.social
This 65-year-old patient presented with bilateral symmetrical proximal upper and lower extremity muscle weakness, dysphagia and skin rash. 🧵

#neuropath #NeuroNotes #pathX #pathology
February 18, 2025 at 2:59 PM
arkanalabs.bsky.social
Teenage male with normal developmental milestones but difficulty playing sports or running.

What is the diagnosis? Check the thread for more diagnostic images 👇

#pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes
March 31, 2025 at 1:08 PM
arkanalabs.bsky.social
Muscle bx was performed on 60 y/o patient w/ complaints of muscle weakness. Several small intramuscular nerve twigs were noted on glutaraldehyde-fixed toluidine blue stained thick sections.

What normal structure is demonstrated in the electron microscopy images?

#NeuroNotes #neuropath #pathology
June 30, 2025 at 1:05 PM
arkanalabs.bsky.social
Correct Answer: Amyloidosis

Head to our blog for a more detailed explanation and additional reading: www.arkanalabs.com/76-year-old-...

#neuropath #neuromuscular #neuronotes #pathology
76-year-old with weakness
Clinical History:The patient has numerous complaints including weakness, myalgia, arthralgia, back pain radiating down bilateral legs, cramps and twitching, imbalance,…
www.arkanalabs.com
July 24, 2025 at 2:06 PM
arkanalabs.bsky.social
(2/2) She is currently taking trazodone, gabapentin, and buspirone. Her physical exam reveals normal sensation and 4/5 strength throughout.

#neuronotes #neuropath
March 17, 2025 at 1:15 PM
arkanalabs.bsky.social
This 75-year-old patient presented with slowly progressive generalized muscle weakness of approximately 2 years’ duration.

What is your diagnosis based images from figures #1 - #4?

#NeuroNotes #neuropath #pathology #neuromuscularpath
May 26, 2025 at 1:08 PM
arkanalabs.bsky.social
1/ The 21-year-old patient presented with skin rash and proximal upper and lower extremity weakness of several weeks duration. Laboratory studies showed elevated CPK (12000 to 14000 range).

#pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes
April 7, 2025 at 2:17 PM
arkanalabs.bsky.social
(1/3) The patient is a 62-year-old man with sudden onset of progressive anesthesia and dysesthesia in hands & feet, and left foot drop. His current medications are atorvastatin, gabapentin, levothyroxine and pregabalin.

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
January 9, 2025 at 3:41 PM
arkanalabs.bsky.social
The patient is an 5-year-old male with progressive muscle weakness and elevated CPK. Gowers maneuver was noted on physical examination. Family history was negative for neuromuscular disorder. A muscle biopsy was performed.

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
December 4, 2024 at 3:00 PM
arkanalabs.bsky.social
(2/2) She has been treated initially with prednisone with only mild improvement. Her lab results show a highest CK of 1582, alkaline phosphatase of 121, CRP of 35.9, and an absolute eosinophilia.

What is the diagnosis?

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
January 27, 2025 at 2:22 PM
arkanalabs.bsky.social
Answer choices:
A.) PCR fragment analysis of CNBP
B.) Muscular dystrophy gene panel
C.) PCR fragment analysis of DPMK
D.) Myositis specific antibody panel

#NeuroNotes #neuropath #pathology #neuromuscularpath #neurosky #pathsky
September 29, 2025 at 1:15 PM
arkanalabs.bsky.social
Head to our blog to read the answer to this week's #NeuroNotes: www.arkanalabs.com/partially-ne...

#neuropath #neuromuscular #pathology
Partially necrotic and regenerating myofibers
Clinical History The 21-year-old patient presented with skin rash and proximal upper and lower extremity weakness of several weeks duration.…
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April 8, 2025 at 3:05 PM
arkanalabs.bsky.social
1/ This 45-year-old patient underwent muscle biopsy to evaluate for muscle weakness. The biopsy showed denervation type changes (neurogenic atrophy). An unusual looking muscle fiber was noted on paraffin sections.

#pathtwitter #pathx #neuromuscularpath #neuropath #neuronotes
April 14, 2025 at 3:30 PM
arkanalabs.bsky.social
2/ Brain MRI was normal. A biopsy was performed.

What is your diagnosis based on H&E, immunohistochemical (EMA, GFAP and KI67) and MYCN FISH images?

#neuromuscularpath #neuropath #neuronotes
April 28, 2025 at 1:07 PM
arkanalabs.bsky.social
This 50-year-old patient underwent muscle biopsy to evaluate for cramps and myalgias.

What is the structure in the image?

#DiagnoseThis #NeuroNotes #neuropath #neuromuscular
March 10, 2025 at 2:11 PM
arkanalabs.bsky.social
Teenage male with normal developmental milestones but difficult playing sports or running.

What is your diagnosis? 

#NeuroNotes #neuropath #pathology #neuromuscularpath
May 5, 2025 at 1:08 PM