In a CKD pt, the fear of giving iv contrast during a CT (to diagnose cancer) is more than the fear of cancer.
I need radiologists/techs to understand that
A. If I’ve signed the form, I know what I’m doing!
B. The risk of “contrast nephrotoxicity” is negligible, perhaps non-existent.
Read the lit!
I need radiologists/techs to understand that
A. If I’ve signed the form, I know what I’m doing!
B. The risk of “contrast nephrotoxicity” is negligible, perhaps non-existent.
Read the lit!
October 24, 2025 at 2:18 AM
In a CKD pt, the fear of giving iv contrast during a CT (to diagnose cancer) is more than the fear of cancer.
I need radiologists/techs to understand that
A. If I’ve signed the form, I know what I’m doing!
B. The risk of “contrast nephrotoxicity” is negligible, perhaps non-existent.
Read the lit!
I need radiologists/techs to understand that
A. If I’ve signed the form, I know what I’m doing!
B. The risk of “contrast nephrotoxicity” is negligible, perhaps non-existent.
Read the lit!
thoughts about using linezolid for empiric CNS coverage to avoid nephrotoxicity from vancomycin?
In situations where an LP isn’t immediately feasible, the combination of empiric vancomycin plus acyclovir can be rough on the kidneys.
In situations where an LP isn’t immediately feasible, the combination of empiric vancomycin plus acyclovir can be rough on the kidneys.
#idsky #neurosky #idcrit
#MRSA/#MRSE CNS infection not responding to IV #Vancomycin, follow @idsainfo.bsky.social ‘17 guidelines & begin intrathecal/intraventricular vanc, or switch to #linezolid?
@bradspellberg.bsky.social @mbrigmon.bsky.social @pulmcrit.bsky.social @idvilchez.bsky.social
#MRSA/#MRSE CNS infection not responding to IV #Vancomycin, follow @idsainfo.bsky.social ‘17 guidelines & begin intrathecal/intraventricular vanc, or switch to #linezolid?
@bradspellberg.bsky.social @mbrigmon.bsky.social @pulmcrit.bsky.social @idvilchez.bsky.social
October 15, 2025 at 8:58 PM
thoughts about using linezolid for empiric CNS coverage to avoid nephrotoxicity from vancomycin?
In situations where an LP isn’t immediately feasible, the combination of empiric vancomycin plus acyclovir can be rough on the kidneys.
In situations where an LP isn’t immediately feasible, the combination of empiric vancomycin plus acyclovir can be rough on the kidneys.
Using #KidneyOrganoids, this #STTT study shows that AAV transduction during #GeneTherapy promotes #Nephrotoxicity by inducing #Genotoxicity and IL-1β secretion, which activates the canonical NFκB pathway. #medsky @harvardmed.bsky.social
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
October 15, 2025 at 9:30 AM
Using #KidneyOrganoids, this #STTT study shows that AAV transduction during #GeneTherapy promotes #Nephrotoxicity by inducing #Genotoxicity and IL-1β secretion, which activates the canonical NFκB pathway. #medsky @harvardmed.bsky.social
#OpenAccess: doi.org/10.1038/s413...
#OpenAccess: doi.org/10.1038/s413...
Blast from past @sfishbane @kdjhaveri @JAMAOnc Nephrotoxicity of the BRAF Inhibitors Vemurafenib and Dabrafenib http://ja.ma/2rntj25
December 9, 2024 at 8:26 PM
Blast from past @sfishbane @kdjhaveri @JAMAOnc Nephrotoxicity of the BRAF Inhibitors Vemurafenib and Dabrafenib http://ja.ma/2rntj25
Nephrotoxicity of the BRAF Inhibitors Vemurafenib and Dabrafenib http://bit.ly/1BRI6FT with @sfishbane @CKINnews @ASNKidney #onconephrology
December 16, 2024 at 2:46 PM
Nephrotoxicity of the BRAF Inhibitors Vemurafenib and Dabrafenib http://bit.ly/1BRI6FT with @sfishbane @CKINnews @ASNKidney #onconephrology
COX-2 inhibitor used for rheumatoid and osteoarthritis; boxed warning for risk of cardiovascular thrombotic events, and GI bleeding/ulceration; hepatotoxicity and nephrotoxicity are possible. Which one?
A. Celecoxib
B. Choroquine
C. Leflunomide
D. Naproxen
The answer is in the thread
#PhunQuiz
A. Celecoxib
B. Choroquine
C. Leflunomide
D. Naproxen
The answer is in the thread
#PhunQuiz
April 11, 2025 at 1:10 AM
COX-2 inhibitor used for rheumatoid and osteoarthritis; boxed warning for risk of cardiovascular thrombotic events, and GI bleeding/ulceration; hepatotoxicity and nephrotoxicity are possible. Which one?
A. Celecoxib
B. Choroquine
C. Leflunomide
D. Naproxen
The answer is in the thread
#PhunQuiz
A. Celecoxib
B. Choroquine
C. Leflunomide
D. Naproxen
The answer is in the thread
#PhunQuiz
Childhood cancer survivors need regular kidney function monitoring to detect nephrotoxicity early and prevent serious health issues.
by Kooijmans ECM, Mulder RL (...) Ehrhardt MJ et 31 al. in J Clin Oncol #MedSky
👉 get more here
📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-02534
by Kooijmans ECM, Mulder RL (...) Ehrhardt MJ et 31 al. in J Clin Oncol #MedSky
👉 get more here
📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-02534
July 29, 2025 at 2:43 PM
Childhood cancer survivors need regular kidney function monitoring to detect nephrotoxicity early and prevent serious health issues.
by Kooijmans ECM, Mulder RL (...) Ehrhardt MJ et 31 al. in J Clin Oncol #MedSky
👉 get more here
📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-02534
by Kooijmans ECM, Mulder RL (...) Ehrhardt MJ et 31 al. in J Clin Oncol #MedSky
👉 get more here
📖 read the article: https://ascopubs.org/doi/10.1200/JCO-24-02534
Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy https://www.biorxiv.org/content/10.1101/2023.09.27.559789v1
Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy https://www.biorxiv.org/content/10.1101/2023.09.27.559789v1
Purpose: Cancer treatment with alpha-emitter-based radioligand therapies (-RLTs) demonstrates promis
www.biorxiv.org
September 30, 2023 at 1:02 AM
Pre-clinical Evaluation of Biomarkers for Early Detection of Nephrotoxicity Following Alpha-particle Radioligand Therapy https://www.biorxiv.org/content/10.1101/2023.09.27.559789v1
Just improved the gentamicin page with updated information on nephrotoxicity.
https://en.wikipedia.org/wiki/Gentamicin
#FiKiWiki
https://en.wikipedia.org/wiki/Gentamicin
#FiKiWiki
Gentamicin - Wikipedia
en.wikipedia.org
December 6, 2024 at 7:31 AM
Just improved the gentamicin page with updated information on nephrotoxicity.
https://en.wikipedia.org/wiki/Gentamicin
#FiKiWiki
https://en.wikipedia.org/wiki/Gentamicin
#FiKiWiki
My first @UpToDate chapter #onconephrology
http://www.uptodate.com/contents/chemotherapy-nephrotoxicity-and-dose-modification-in-patients-with-renal-insufficiency-conventional-cytotoxic-agents
http://www.uptodate.com/contents/chemotherapy-nephrotoxicity-and-dose-modification-in-patients-with-renal-insufficiency-conventional-cytotoxic-agents
UpToDate
www.uptodate.com
December 15, 2024 at 6:41 PM
Methotrexate nephrotoxicity, The #Onconephrology Forum Series! https://nephinp.wordpress.com/2019/11/30/methotrexate-nephrotoxicity-the-onconephrology-forum-series/ via @M_Elraggal
Methotrexate nephrotoxicity, The Onconephrology Forum Ser...
Source: Oncologist. 2016 Dec; 21(12): 1471–1482. DHFR: di...
nephinp.wordpress.com
December 13, 2024 at 10:31 PM
Methotrexate nephrotoxicity, The #Onconephrology Forum Series! https://nephinp.wordpress.com/2019/11/30/methotrexate-nephrotoxicity-the-onconephrology-forum-series/ via @M_Elraggal
Saini, S., Rani, L., Shukla, N., Thakur, R. S., Patel, D. K., Ansari, M. S., Banerjee, M. and Gautam, N. K. (2023). Hsp27 over expression protect against cadmium induced nephrotoxicity in #Drosophila. Comp Biochem Physiol C Toxicol Pharmacol: 109716. www.sciencedirect.com/science/arti...
December 15, 2023 at 6:27 PM
Saini, S., Rani, L., Shukla, N., Thakur, R. S., Patel, D. K., Ansari, M. S., Banerjee, M. and Gautam, N. K. (2023). Hsp27 over expression protect against cadmium induced nephrotoxicity in #Drosophila. Comp Biochem Physiol C Toxicol Pharmacol: 109716. www.sciencedirect.com/science/arti...
And there is the longer term followup study AURORA 2 that did not show signs of nephrotoxicity (concern of course with CNI)
pubmed.ncbi.nlm.nih.gov/37466424/
pubmed.ncbi.nlm.nih.gov/37466424/
Safety and Efficacy of Long-Term Voclosporin Treatment for Lupus Nephritis in the Phase 3 AURORA 2 Clinical Trial - PubMed
Data demonstrate the safety and efficacy of long-term voclosporin treatment over three years of follow-up in patients with LN.
pubmed.ncbi.nlm.nih.gov
October 1, 2025 at 7:56 PM
And there is the longer term followup study AURORA 2 that did not show signs of nephrotoxicity (concern of course with CNI)
pubmed.ncbi.nlm.nih.gov/37466424/
pubmed.ncbi.nlm.nih.gov/37466424/
Cellular casts containing #renal #tubular #epithelial cells and a few WBCs SM-stained (left) and unstained. #AKI due to #ischemic #ATN Plus toxic ATN 2/2 cisplatin #nephrotoxicity #urinarysediment #pisseprophet #spinyourownurine #liquidkidneybiopsy
December 18, 2024 at 6:17 PM
Cellular casts containing #renal #tubular #epithelial cells and a few WBCs SM-stained (left) and unstained. #AKI due to #ischemic #ATN Plus toxic ATN 2/2 cisplatin #nephrotoxicity #urinarysediment #pisseprophet #spinyourownurine #liquidkidneybiopsy
Our new study evaluating gentamicin dosing strategies for endocarditis was published in @jac_amr! We saw HUGE rates of nephrotoxicity (~50%) in the divided dosing group. Next research question from our MGB group - time to ditch gent altogether?
November 21, 2024 at 2:40 PM
Our new study evaluating gentamicin dosing strategies for endocarditis was published in @jac_amr! We saw HUGE rates of nephrotoxicity (~50%) in the divided dosing group. Next research question from our MGB group - time to ditch gent altogether?
nth.
Conclusion
This case underscores the importance of recognizing isolated nephrotoxicity as a distinct clinical entity in paracetamol overdose. Early identification, supportive management, and close monitoring are crucial for favorable outcomes.
Conclusion
This case underscores the importance of recognizing isolated nephrotoxicity as a distinct clinical entity in paracetamol overdose. Early identification, supportive management, and close monitoring are crucial for favorable outcomes.
November 25, 2024 at 5:48 AM
nth.
Conclusion
This case underscores the importance of recognizing isolated nephrotoxicity as a distinct clinical entity in paracetamol overdose. Early identification, supportive management, and close monitoring are crucial for favorable outcomes.
Conclusion
This case underscores the importance of recognizing isolated nephrotoxicity as a distinct clinical entity in paracetamol overdose. Early identification, supportive management, and close monitoring are crucial for favorable outcomes.
Vancomycin and piperacillin tazobactam friends or foes?!
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
November 18, 2024 at 3:49 AM
Vancomycin and piperacillin tazobactam friends or foes?!
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
Pseudo or true nephrotoxicity?
#idsky
www.nephjc.com/news/pip-taz...
What’s wrong with NSAIDs?
What’s the most common analgesics we personally use?
There’s no kidney function left to damage anymore in dialysis (leaving the Q of nephrotoxicity aside)
#NephJC
What’s the most common analgesics we personally use?
There’s no kidney function left to damage anymore in dialysis (leaving the Q of nephrotoxicity aside)
#NephJC
January 22, 2025 at 1:58 AM
What’s wrong with NSAIDs?
What’s the most common analgesics we personally use?
There’s no kidney function left to damage anymore in dialysis (leaving the Q of nephrotoxicity aside)
#NephJC
What’s the most common analgesics we personally use?
There’s no kidney function left to damage anymore in dialysis (leaving the Q of nephrotoxicity aside)
#NephJC
Editorial: When the drug induces kidney diseases: nephrotoxicity and intoxication/poisoning - goo.gl/alerts/NTRGZK #GoogleAlerts
goo.gl
May 20, 2025 at 2:36 AM
Editorial: When the drug induces kidney diseases: nephrotoxicity and intoxication/poisoning - goo.gl/alerts/NTRGZK #GoogleAlerts
2/ Why do we adjust doses?🤔
2 main reasons for renal dose adjustments in critically ill patients:
👉Prevent toxicity (eg. vancomycin, aminoglycosides to reduce nephrotoxicity/ototoxicity)
👉 Save $$$ (eg optimizing beta-lactam concentrations)
It isn't an efficacy issue (theoretically more=↑effective)
2 main reasons for renal dose adjustments in critically ill patients:
👉Prevent toxicity (eg. vancomycin, aminoglycosides to reduce nephrotoxicity/ototoxicity)
👉 Save $$$ (eg optimizing beta-lactam concentrations)
It isn't an efficacy issue (theoretically more=↑effective)
an elderly woman says that 's quite effective in front of a white board
ALT: an elderly woman says that 's quite effective in front of a white board
media.tenor.com
December 13, 2024 at 9:19 PM
2/ Why do we adjust doses?🤔
2 main reasons for renal dose adjustments in critically ill patients:
👉Prevent toxicity (eg. vancomycin, aminoglycosides to reduce nephrotoxicity/ototoxicity)
👉 Save $$$ (eg optimizing beta-lactam concentrations)
It isn't an efficacy issue (theoretically more=↑effective)
2 main reasons for renal dose adjustments in critically ill patients:
👉Prevent toxicity (eg. vancomycin, aminoglycosides to reduce nephrotoxicity/ototoxicity)
👉 Save $$$ (eg optimizing beta-lactam concentrations)
It isn't an efficacy issue (theoretically more=↑effective)
🚫 No mortality benefit has been demonstrated by the empiric addition of vancomycin in FN without an indication. [PMID: 2019772]
⚠️ Vancomycin overuse has been associated with the development of resistance (e.g., VRE), as well as nephrotoxicity and other undesirable side effects.
⚠️ Vancomycin overuse has been associated with the development of resistance (e.g., VRE), as well as nephrotoxicity and other undesirable side effects.
February 10, 2025 at 7:40 PM
🚫 No mortality benefit has been demonstrated by the empiric addition of vancomycin in FN without an indication. [PMID: 2019772]
⚠️ Vancomycin overuse has been associated with the development of resistance (e.g., VRE), as well as nephrotoxicity and other undesirable side effects.
⚠️ Vancomycin overuse has been associated with the development of resistance (e.g., VRE), as well as nephrotoxicity and other undesirable side effects.
Nephrotoxicity in CAR-T cell therapy - Transplantation and Cellular Therapy @astct.bsky.social www.astctjournal.org/article/S266...
Nephrotoxicity in CAR-T cell therapy
Modern immunotherapies revolutionize cancer treatment. Due to advances in molecular
biology, therapies such as immune checkpoint inhibitors, naked, armed, and bispecific
monoclonal antibodies, and chi...
www.astctjournal.org
March 20, 2025 at 12:59 PM
Nephrotoxicity in CAR-T cell therapy - Transplantation and Cellular Therapy @astct.bsky.social www.astctjournal.org/article/S266...
Children w/cancer have had significant improvements in cure rates, but survivors have been left w/long-term adverse effects, including nephrotoxicity. Read this Educational Review of nephrotoxicity of immunotherapy & therapies used to treat pediatric cancer.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
July 9, 2025 at 7:13 PM
Children w/cancer have had significant improvements in cure rates, but survivors have been left w/long-term adverse effects, including nephrotoxicity. Read this Educational Review of nephrotoxicity of immunotherapy & therapies used to treat pediatric cancer.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
This suggests that this natural nano-drug could be a promising therapeutic approach to mitigate the nephrotoxicity associated with cisplatin treatment.
August 3, 2025 at 4:21 PM
This suggests that this natural nano-drug could be a promising therapeutic approach to mitigate the nephrotoxicity associated with cisplatin treatment.
Vancomycin-associated Tubular Casts and Vancomycin Nephrotoxicity - Kidney International Reports https://www.kireports.org/article/S2468-0249(21)01148-7/fulltext?dgcid=raven_jbs_aip_email#%20
December 11, 2024 at 4:41 PM
Vancomycin-associated Tubular Casts and Vancomycin Nephrotoxicity - Kidney International Reports https://www.kireports.org/article/S2468-0249(21)01148-7/fulltext?dgcid=raven_jbs_aip_email#%20