#medsky🩺🧪
Update on grants #ScienceSky #MedSky 🩺🧪
You might start seeing some grant money roll in, yay.

Con: fed is given benefit of the doubt it will start to review fairly (it won't)
On delayed application review, the NIH grant terminations lawsuit appears to be headed for a settlement.

Both plaintiffs and defendants have submitted a joint document outlining their agreement. Judge Young must sign off on it before it takes effect.

Here's what it says and what all this means 🧵
December 30, 2025 at 3:12 PM
Cool stuff from @washumedicine.bsky.social about how stimulant medications work. Not by activating attention, but rather, reward (dopamine). The stimulant provides MOTIVATION to focus. 🧪 🩺 #MedSky #PsychSky
This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...
December 25, 2025 at 7:51 PM
December 25, 2025 at 10:19 AM
How to talk folks off the misinfo cliff. Give yourself plenty of slack as these talks can be infuriating.

"We're both getting emotional, let's revisit this talk later"
or
"I'm getting pissed off so let's drop it for now, but I'm not going to give up on you. I want you to live." 🩺 🧪 #MedSky
This Christmas: are you seeing family who might have fallen prey to pseudoscience or health misinformation?

Find tips to build trust, find common ground, replace strongly held beliefs with evidence.

Read it here:
🔗 news.immunologic.org/all-i-want-f...

Merry Christmas everyone 🎄
All I Want for Christmas Is Fewer Pseudoscience Takes
A scientist’s guide to navigating health misinformation at the holiday table.
news.immunologic.org
December 25, 2025 at 7:27 PM
December 24, 2025 at 9:37 AM
December 23, 2025 at 5:26 PM
#Stress hormones and sympathetic activation raise blood glucose. Additionally, a positive feedback loop links proinflammatory #cytokine​s to glycaemia. In critical illness, the stress hyperglycaemia ratio helps to distinguish the effects of acute stress from underlying #hyperglycaemia.

🧪 🩺 #MedSky
December 20, 2025 at 9:47 PM
#Hyperuricaemia is strongly associated with the metabolic syndrome (MetS). It is assumed that increased uric acid may be both cause and consequence of #MetS and its components (obesity, hypertension, dyslipidemia, and impaired glucose homeostasis, including type 2 diabetes)

1/2

🧪 🩺 #MedSky
December 21, 2025 at 10:02 AM
A recent scientometric analysis confirms this relationship with respect to #diabetes mellitus, uncovering trends in treatment strategies and potential molecular mechanisms based on 1464 studies.

2/2

🧪 🩺 #MedSky

www.livivo.de/doc/M39991045
pubmed.ncbi.nlm.nih.gov/39991045/
doi.org/10.3389/fend...
December 21, 2025 at 10:02 AM
#Hyperuricaemia is a metabolic disease leading to multiple complications, e.g. gouty arthritis, renal failure, etc. In the setting of Hyperuricaemia, #gout arises as a consequence of positive feedback of elevated urate concentration and impaired kidney function.

🧪 🩺 # MedSky
December 20, 2025 at 12:05 PM
#Resveratrol, a compound contained in berries, peanuts, & wine, is beneficial in gout. Combining modelling techniques of network pharmacology with metabolomics revealed probable mechanisms of action.

🧪🩺 #MedSky

www.livivo.de/doc/M39534253
pubmed.ncbi.nlm.nih.gov/39534253/
doi.org/10.3389/fend...
December 20, 2025 at 12:05 PM
This man is endangering the health of the nation's children, everyone's health! The longer he is in power, corruption, chronic disease and death will take hold. He is the embodiment of human pestilence. #ImpeachRFKJr #MedSky #ScienceSky 🩺🧪
🚨 Today, I formally introduced articles of impeachment against Robert F. Kennedy, Jr.

RFK Jr. has turned his back on science and the safety of the American people. Michiganders cannot take another day of his chaos.
December 10, 2025 at 1:28 PM
There is no plan to prevent the next pandemic. If there was a functional CDC or USDA, there might have been some protocol for this situation but U.S. public health is in "catch-as-catch-can" mode.
There is no plan, no collective response, only individuals "doing their own research." 🩺🧪 #MedSky
December 9, 2025 at 5:21 PM
Gardasil can be eye-wateringly expensive if you are underinsured but Harvard epidemiologists might have some good news for people in lower income countries and the underinsured! medicalnewsbulletin.com/hpv-vaccine-... 🧪 Medskies medsky 🩺⚕️ PedSky health equity reprosky
How many HPV shots do I need? | Medical News Bulletin
Great news for people who need to pay cash for HPV shots. Come over to find out why it might soon be less expensive to protect your kids (and yourself).
medicalnewsbulletin.com
December 5, 2025 at 3:21 PM
Wake up to some nutrition science: #ScienceSky #MedSky #NutritionSky 🩺 🧪🔬
"Sugar free" candies often contain sugar alcohols that were thought to be expelled from the body but that is not the case with sorbitol. source.washu.edu/2025/11/alte...
Alternative sweetener sorbitol linked to liver disease
A study from researchers at Washington University in St. Louis has found connections between the alternative sweetener sorbitol and liver disease.
source.washu.edu
December 4, 2025 at 2:14 PM
With GLP-1 based treatments ubiquitous it's time to check in on safety. Have you had side effects from ozempic? medicalnewsbulletin.com/ozempic-and-...
#GISky #GastroSky Medskies medtwitter medsky 🩺 ⚕️ 🍎📃 public health #drugsafety 🧪
Ozempic and Victoza: Designer Diet Drug Drawbacks | Medical News Bulletin
People turning to GLP-1 agonists like Ozempic and Victoza to aid weight loss should think twice, say Canadian pharmacologists.
medicalnewsbulletin.com
December 1, 2025 at 4:26 PM
Read this article before you bulk and cut. The metabolic changes that take place during repeated cycles of weight loss and gain have a pernicious effect on your heart! medicalnewsbulletin.com/yo-yo-diet-h... 🧪 #bodybuilding #immunosky #lymphocyte lipidtime Medskies medsky 🩺 ⚕️
Why Crash Dieting Is Hurting Your Heart | Medical News Bulletin
You might have heard that Yo-yo dieting makes you more vulnerable to heart disease, but why is that? Scientists say they might have an answer.
medicalnewsbulletin.com
November 25, 2025 at 5:45 PM
Here I cover in @forbes.com how many clinical trials have been disrupted by Trump administration NIH grant terminations and how many patients may have been affected

🛟 🧪 😷 #AcademicSky #MedSky #episky🩺 #HiSciSky Public Health #science

www.forbes.com/sites/brucel...
NIH Grant Cuts Have Disrupted 383 Clinical Trials With 74,311 Patients
A study found that Trump administration NIH grant cuts led to termination of 118 trials studying cancer, 97 studying infectious diseases and 140 testing new treatments.
www.forbes.com
November 21, 2025 at 10:16 PM
Adults with the highest levels of physical activity at midlife and late life had 41% and 45% lower risk of all-cause #dementia, compared with those with the lowest levels of physical activity.

I guess we better get exercising folks

#medsky 🩺🧪
Physical Activity Over the Adult Life Course and Risk of Dementia
This cohort study uses data from the Framingham Heart Study to evaluate whether higher physical activity levels in early adult life, midlife, or late life are associated with lower risk of all-cause o...
jamanetwork.com
November 20, 2025 at 3:38 AM
Nope, absolutely not. This is defacement of public property and this CDC needs to be sued. This is public endangerment, endangering children! 🧪 #ScienceSky #MedSky 🩺
I want to scream so loudly I shatter the moon, what's it going to take!?
CDC has overhauled its website to assert that “the claim ‘vaccines do not cause autism’ is not an evidence-based claim”
November 20, 2025 at 3:16 AM
How Early Detection Helped Maria Menounos Against Pancreatic Cancer

Here I cover in @forbes.com my conversation with Maria Menounos

🛟 🧪 😷 #AcademicSky #MedSky #episky🩺 #HiSciSky Public Health #science

www.forbes.com/sites/brucel...
How Early Detection Helped Maria Menounos Against Pancreatic Cancer
Maria Menounos talked about her experiences with having a meningioma and then a neuroendocrine cancer of her pancreas and the importance of early detection of cancer.
www.forbes.com
November 17, 2025 at 3:39 PM
A detailed analysis of the immune response to a pig-to-human kidney transplant in a brain-dead patient over a period of two months is reported in two studies in Nature. Read here: spklr.io/63329BMpeR and here: spklr.io/63321BMpeT

#medsky 🩺⚕️#Xenotransplantation 🧪
Physiology and immunology of pig-to-human decedent kidney xenotransplant - Nature
Xenotransplantation of genetically-modified pig kidneys offers a solution to the scarcity of organs for end-stage renal disease patients.1 We performed a 61-day alpha-Gal knock-out pig kidney and thymic autograft transplant into a nephrectomized brain-dead human using clinically approved immunosuppression, without CD40 blockade or additional genetic modification. Hemodynamic and electrolyte stability and dialysis independence were achieved. Post-operative day (POD) 10 biopsies revealed glomerular IgM and IgA deposition, activation of early complement components and mesangiolysis with stable renal function without proteinuria, a phenotype not seen in allotransplantation. On POD 33, an abrupt increase in serum creatinine was associated with antibody-mediated rejection and increased donor-specific IgG. Plasma exchange, C3/C3b inhibition and rabbit anti-thymocyte globulin (rATG), completely reversed xenograft rejection. Pre-existing donor-reactive T cell clones expanded progressively in the circulation post-transplant, acquired an effector transcriptional profile and were detected in the POD 33 rejecting xenograft prior to rATG treatment. This study provides the first long-term physiologic, immunologic, and infectious disease monitoring of a pig-to-human kidney xenotransplant and indicates that pre-existing xenoreactive T cells and induced antibodies to unknown epitope(s) present a major challenge, despite significant immunosuppression. It also demonstrates that a minimally gene-edited pig kidney can support long-term life-sustaining physiologic functions in a human.
spklr.io
November 17, 2025 at 11:05 AM
New H3N2 Subclade K Flu Strain Sparks Fears Of ‘Cruel Winter’
Here's my coverage in @forbes.com of this
🛟 🧪 😷 #AcademicSky #MedSky #episky🩺 #HiSciSky Public Health #science

www.forbes.com/sites/brucel...
New H3N2 Subclade K Flu Strain Sparks Fears Of ‘Cruel Winter’
A new influenza A strain subclade K is circulating due to H3N2 picking up seven mutations this summer. Will this lead to a worse flu season through the winter.
www.forbes.com
November 14, 2025 at 6:37 PM
Breathing Through Your Butt Is Closer As An Option After New Study
Here's my coverage in @forbes.com of the possibility of butt-breathing
🛟 🧪 😷 #AcademicSky #MedSky #episky🩺 #HiSciSky Public Health #science

www.forbes.com/sites/brucel...
Breathing Through Your Butt Is Closer As An Option After New Study
A new study shows progress in the possibility of butt breathing. Here's what's behind the possibility of injecting oxygen- carrying perfluorodecalin up into your rectum.
www.forbes.com
November 14, 2025 at 6:48 PM