🧬🛡️How are new immune mechanisms created?
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
November 27, 2025 at 9:35 AM
🧬🛡️How are new immune mechanisms created?
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!
doi.org/10.1073/pnas...
Overall, Lamassu keeps its nuclease (LmuA) inactive within the LmuA₁B₂C₁ complex.
When viral replication begins, Lamassu senses the replication intermediates, triggering an ATP-dependent rearrangement that releases LmuA.
LmuA tetramerizes into an active nuclease that dregades cellular DNA.
When viral replication begins, Lamassu senses the replication intermediates, triggering an ATP-dependent rearrangement that releases LmuA.
LmuA tetramerizes into an active nuclease that dregades cellular DNA.
November 27, 2025 at 9:35 AM
Overall, Lamassu keeps its nuclease (LmuA) inactive within the LmuA₁B₂C₁ complex.
When viral replication begins, Lamassu senses the replication intermediates, triggering an ATP-dependent rearrangement that releases LmuA.
LmuA tetramerizes into an active nuclease that dregades cellular DNA.
When viral replication begins, Lamassu senses the replication intermediates, triggering an ATP-dependent rearrangement that releases LmuA.
LmuA tetramerizes into an active nuclease that dregades cellular DNA.
We looked for Lamassu across ~23,000 genomes, and found 3,829 Lamassu ! They are present in ~15% of prokaryotes.
They fall into two major clades, long and short, with short Lamassu being far more diverse, modular and widespread. How can such modularity evolve at the structural level ?
They fall into two major clades, long and short, with short Lamassu being far more diverse, modular and widespread. How can such modularity evolve at the structural level ?
November 27, 2025 at 9:35 AM
We looked for Lamassu across ~23,000 genomes, and found 3,829 Lamassu ! They are present in ~15% of prokaryotes.
They fall into two major clades, long and short, with short Lamassu being far more diverse, modular and widespread. How can such modularity evolve at the structural level ?
They fall into two major clades, long and short, with short Lamassu being far more diverse, modular and widespread. How can such modularity evolve at the structural level ?
Why did Lamassu attract our attention?
Because its core protein, LmuB, belongs to the SMC family, a family usually dedicated to chromosome organization and DNA repair, not immunity.
This raised an intriguing possibility: had bacteria repurposed a repair machine as a viral sensor?
Because its core protein, LmuB, belongs to the SMC family, a family usually dedicated to chromosome organization and DNA repair, not immunity.
This raised an intriguing possibility: had bacteria repurposed a repair machine as a viral sensor?
November 27, 2025 at 9:35 AM
Why did Lamassu attract our attention?
Because its core protein, LmuB, belongs to the SMC family, a family usually dedicated to chromosome organization and DNA repair, not immunity.
This raised an intriguing possibility: had bacteria repurposed a repair machine as a viral sensor?
Because its core protein, LmuB, belongs to the SMC family, a family usually dedicated to chromosome organization and DNA repair, not immunity.
This raised an intriguing possibility: had bacteria repurposed a repair machine as a viral sensor?
Sketching practice and came up with the idea of Bronze Rage ©️
Story of a disgraced greek aristocrat turned dancer and his young Lamassu companion
Story of a disgraced greek aristocrat turned dancer and his young Lamassu companion
November 23, 2025 at 11:03 PM
Sketching practice and came up with the idea of Bronze Rage ©️
Story of a disgraced greek aristocrat turned dancer and his young Lamassu companion
Story of a disgraced greek aristocrat turned dancer and his young Lamassu companion
Where did such a system come from?
Phylogenetic & structural comparisons point to a clear origin: the SbcCD DNA-repair complex. Lamassu emerged through sequential step including coiled-coil shortening, loss of SbcCD nuclease and integration of modular effectors into LmuA.
Phylogenetic & structural comparisons point to a clear origin: the SbcCD DNA-repair complex. Lamassu emerged through sequential step including coiled-coil shortening, loss of SbcCD nuclease and integration of modular effectors into LmuA.
November 27, 2025 at 9:35 AM
Where did such a system come from?
Phylogenetic & structural comparisons point to a clear origin: the SbcCD DNA-repair complex. Lamassu emerged through sequential step including coiled-coil shortening, loss of SbcCD nuclease and integration of modular effectors into LmuA.
Phylogenetic & structural comparisons point to a clear origin: the SbcCD DNA-repair complex. Lamassu emerged through sequential step including coiled-coil shortening, loss of SbcCD nuclease and integration of modular effectors into LmuA.
Ea Nasir :v
Based it on a silly meme I saw with the Lamassu whispering to him xD
Based it on a silly meme I saw with the Lamassu whispering to him xD
November 22, 2025 at 2:54 AM
Ea Nasir :v
Based it on a silly meme I saw with the Lamassu whispering to him xD
Based it on a silly meme I saw with the Lamassu whispering to him xD
Part 93 of 200 in historically interesting things to inspire your ttrpg dnd
2,700-year-old Assyrian lamassu at ancient Dur-Sharrukin
2,700-year-old Assyrian lamassu at ancient Dur-Sharrukin
November 14, 2025 at 2:47 AM
Part 93 of 200 in historically interesting things to inspire your ttrpg dnd
2,700-year-old Assyrian lamassu at ancient Dur-Sharrukin
2,700-year-old Assyrian lamassu at ancient Dur-Sharrukin
I promise that i ever come into millions, I'll commission you to make a pair of Assyrian Lamassu for my front door, how about that?
November 14, 2025 at 4:53 PM
I promise that i ever come into millions, I'll commission you to make a pair of Assyrian Lamassu for my front door, how about that?
Yo ho so my Twitter got locked so i decided to say f u twitter I quit anyway. Bluesky is better than you anyway. So with that anyone wanna be moots with this firey lamassu? I promise I won’t start fires 👉🏻👈🏻 or use fireball. #Vtuber #Vtubersupport
November 8, 2025 at 4:56 PM
Yo ho so my Twitter got locked so i decided to say f u twitter I quit anyway. Bluesky is better than you anyway. So with that anyone wanna be moots with this firey lamassu? I promise I won’t start fires 👉🏻👈🏻 or use fireball. #Vtuber #Vtubersupport
Finished up my proxy for a Daemonsmith on Infernal Taurus until I can get the real kit. This is a 3d print based on the old Lamassu. Additional pics in the comments.
#warhammercommunity #ageofsigmar #aos #paintingwarhammer #warhammer #chaosdwarfs #miniaturepainting #nerdlings #helsmithsofhashut
#warhammercommunity #ageofsigmar #aos #paintingwarhammer #warhammer #chaosdwarfs #miniaturepainting #nerdlings #helsmithsofhashut
October 27, 2025 at 3:18 AM
Finished up my proxy for a Daemonsmith on Infernal Taurus until I can get the real kit. This is a 3d print based on the old Lamassu. Additional pics in the comments.
#warhammercommunity #ageofsigmar #aos #paintingwarhammer #warhammer #chaosdwarfs #miniaturepainting #nerdlings #helsmithsofhashut
#warhammercommunity #ageofsigmar #aos #paintingwarhammer #warhammer #chaosdwarfs #miniaturepainting #nerdlings #helsmithsofhashut
Assyrian winged bull necklace 🐂🪽
Based on the lamassu (guardian of the gates) at Dur Sharrukin, Iraq.
🛍️ tephraarts.etsy.com/listing/4393...
#archaeology #assyria #mesopotamia #bull
Based on the lamassu (guardian of the gates) at Dur Sharrukin, Iraq.
🛍️ tephraarts.etsy.com/listing/4393...
#archaeology #assyria #mesopotamia #bull
October 27, 2025 at 12:10 PM
Assyrian winged bull necklace 🐂🪽
Based on the lamassu (guardian of the gates) at Dur Sharrukin, Iraq.
🛍️ tephraarts.etsy.com/listing/4393...
#archaeology #assyria #mesopotamia #bull
Based on the lamassu (guardian of the gates) at Dur Sharrukin, Iraq.
🛍️ tephraarts.etsy.com/listing/4393...
#archaeology #assyria #mesopotamia #bull
i think its time to go back and rework some of my sphinx worldbuilding for my plans to add manticore and lamassu
October 25, 2025 at 11:12 PM
i think its time to go back and rework some of my sphinx worldbuilding for my plans to add manticore and lamassu
Guillermo Muñoz Vera. Lamassu, 2013
October 20, 2025 at 5:47 PM
Guillermo Muñoz Vera. Lamassu, 2013
The only time cherubim have a definite description is in Ezekiel, where they have human bodies, wings, and four faces. However, the word is probably cognate with an Assyrian word for the lamassu or shedu, they pull the chariot of God, and their spread wings serve as a seat for God.
October 15, 2025 at 1:21 PM
The only time cherubim have a definite description is in Ezekiel, where they have human bodies, wings, and four faces. However, the word is probably cognate with an Assyrian word for the lamassu or shedu, they pull the chariot of God, and their spread wings serve as a seat for God.
New online: Structure and activation mechanism of a Lamassu phage and plasmid defense system
Structure and activation mechanism of a Lamassu phage and plasmid defense system
Nature Structural & Molecular Biology, Published online: 14 October 2025; doi:10.1038/s41594-025-01677-4Li et al. show that a Lamassu defense system protects bacteria from phage infection by activating a lethal tetrameric DNA-cutting enzyme. In the absence of phages, a protein clamp holds the enzyme as an inactive monomer, preventing self-damage.
go.nature.com
October 14, 2025 at 11:15 AM
New online: Structure and activation mechanism of a Lamassu phage and plasmid defense system
Yo #portfolioday ! ! !
I'm Freyorr! I don't have much time to draw anymore, but I mostly draw my ocs and the occasional map :-)
I'm Freyorr! I don't have much time to draw anymore, but I mostly draw my ocs and the occasional map :-)
October 14, 2025 at 5:34 PM
Yo #portfolioday ! ! !
I'm Freyorr! I don't have much time to draw anymore, but I mostly draw my ocs and the occasional map :-)
I'm Freyorr! I don't have much time to draw anymore, but I mostly draw my ocs and the occasional map :-)
It’s time for the tie with the miniature Lamassu(s)…
October 6, 2025 at 1:45 PM
It’s time for the tie with the miniature Lamassu(s)…
This week's listening habits
October 4, 2025 at 11:52 PM
This week's listening habits
Mytologické bytosti starověké Mezopotámie
Mezopotámská mytologie je plná fascinujících bytostí. Mezi nejznámější patří Lamassu, ochranné božství, a Pazuzu, démon domova. Dalšími jsou Uridimmu, strážci chrámů, a Anzu, levohlavý orel. Každá z těchto bytostí má jedinečný příběh.
Mezopotámská mytologie je plná fascinujících bytostí. Mezi nejznámější patří Lamassu, ochranné božství, a Pazuzu, démon domova. Dalšími jsou Uridimmu, strážci chrámů, a Anzu, levohlavý orel. Každá z těchto bytostí má jedinečný příběh.
March 29, 2024 at 3:51 PM
Mytologické bytosti starověké Mezopotámie
Mezopotámská mytologie je plná fascinujících bytostí. Mezi nejznámější patří Lamassu, ochranné božství, a Pazuzu, démon domova. Dalšími jsou Uridimmu, strážci chrámů, a Anzu, levohlavý orel. Každá z těchto bytostí má jedinečný příběh.
Mezopotámská mytologie je plná fascinujících bytostí. Mezi nejznámější patří Lamassu, ochranné božství, a Pazuzu, démon domova. Dalšími jsou Uridimmu, strážci chrámů, a Anzu, levohlavý orel. Každá z těchto bytostí má jedinečný příběh.
A very old set of ballpoint pen sketches, from a mythical creatures list I did one year.
Ahklut, Baku, Lamassu, a weird Disney take on a Chimera lol
Ahklut, Baku, Lamassu, a weird Disney take on a Chimera lol
October 7, 2023 at 12:23 AM
A very old set of ballpoint pen sketches, from a mythical creatures list I did one year.
Ahklut, Baku, Lamassu, a weird Disney take on a Chimera lol
Ahklut, Baku, Lamassu, a weird Disney take on a Chimera lol
You left your Lamassu at Khorsabad? Oh.
December 22, 2024 at 3:35 PM
You left your Lamassu at Khorsabad? Oh.
Labubu = Lamassu × Pazuzu
If you know basic kabbalah it's actually not too hard to make a golem out of a labubu. Don't recommend it though. They have a pre-existing body-dharma. As soon as they wake they run straight for the sea. V hard to counter. Lost the first one. No idea what it's doing out there. Moved like lightning.
October 10, 2025 at 4:51 AM
Labubu = Lamassu × Pazuzu
i desire attention, reskeet a girl dick (it's me. i'm the dick)
November 5, 2023 at 7:09 AM
i desire attention, reskeet a girl dick (it's me. i'm the dick)