Jaque-Fernandez, Allard et al. @cnrs.fr show that depolarization of #zebrafish #SkeletalMuscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers rupress.org/jgp/article/...
November 11, 2025 at 5:02 PM
Jaque-Fernandez, Allard et al. @cnrs.fr show that depolarization of #zebrafish #SkeletalMuscle fibers evokes a Mn²⁺ quenching signal that does not result from store-operated Ca²⁺ entry but from a displacement of Mn²⁺ accumulated on intracellular Ca²⁺ buffers rupress.org/jgp/article/...
N. J. Ayres, et al.: Ultracold neutron energy spectrum and storage properties from magnetically induced spin depolarization https://arxiv.org/abs/2511.06884 https://arxiv.org/pdf/2511.06884 https://arxiv.org/html/2511.06884
November 11, 2025 at 6:43 AM
N. J. Ayres, et al.: Ultracold neutron energy spectrum and storage properties from magnetically induced spin depolarization https://arxiv.org/abs/2511.06884 https://arxiv.org/pdf/2511.06884 https://arxiv.org/html/2511.06884
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner: doi.org/10.1016/j.ce...
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
November 9, 2025 at 8:56 PM
REM sleep reduces subthreshold depolarization in cortical pyramidal neurons in a region-specific manner: doi.org/10.1016/j.ce...
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
"NMDA receptors drive subthreshold depolarization specifically during REM sleep."
Racial Depolarization cancelled?
🤔
🤔
November 8, 2025 at 6:07 PM
Racial Depolarization cancelled?
🤔
🤔
Collin and Denton counties are still subject to the laws of demographics & marginal depolarization.
It's inevitable Texas will flip. Only question is timing; the way things are headed it's getting closer by day.
My theory is a direct correlation between WTI and R vote share.
Prove me wrong.
It's inevitable Texas will flip. Only question is timing; the way things are headed it's getting closer by day.
My theory is a direct correlation between WTI and R vote share.
Prove me wrong.
November 8, 2025 at 5:24 PM
Collin and Denton counties are still subject to the laws of demographics & marginal depolarization.
It's inevitable Texas will flip. Only question is timing; the way things are headed it's getting closer by day.
My theory is a direct correlation between WTI and R vote share.
Prove me wrong.
It's inevitable Texas will flip. Only question is timing; the way things are headed it's getting closer by day.
My theory is a direct correlation between WTI and R vote share.
Prove me wrong.
Would probs have to entail a sharp depolarization of suburban southern whites which probs means the GOP gets locked out of power for a decade
November 8, 2025 at 1:17 AM
Would probs have to entail a sharp depolarization of suburban southern whites which probs means the GOP gets locked out of power for a decade
Charestiste Posted this on Twitter.
@charestiste.bsky.social
Complete depolarization. Rutland to the right of upper mission (arguably) is a first.
Dilworth and Glenmore likely decided this. I can’t believe how red south central is too.
@charestiste.bsky.social
Complete depolarization. Rutland to the right of upper mission (arguably) is a first.
Dilworth and Glenmore likely decided this. I can’t believe how red south central is too.
November 7, 2025 at 6:33 AM
Charestiste Posted this on Twitter.
@charestiste.bsky.social
Complete depolarization. Rutland to the right of upper mission (arguably) is a first.
Dilworth and Glenmore likely decided this. I can’t believe how red south central is too.
@charestiste.bsky.social
Complete depolarization. Rutland to the right of upper mission (arguably) is a first.
Dilworth and Glenmore likely decided this. I can’t believe how red south central is too.
Heart function also improved in treated DMD rats. In the wild type animals treated with the high GT dose however an increased QT interval was seen. This has to do with the polarization and depolarization of the heart and is a risk factor for arrhythmia
November 6, 2025 at 9:15 PM
Heart function also improved in treated DMD rats. In the wild type animals treated with the high GT dose however an increased QT interval was seen. This has to do with the polarization and depolarization of the heart and is a risk factor for arrhythmia
This research paper presents a novel energy calculation algorithm that leverages quantum phase difference estimation (QPDE) and tensor-network-based unitary compression. The algorithm efficiently implements QPDE, reducing depolarization noise exponentially.
November 6, 2025 at 1:11 PM
This research paper presents a novel energy calculation algorithm that leverages quantum phase difference estimation (QPDE) and tensor-network-based unitary compression. The algorithm efficiently implements QPDE, reducing depolarization noise exponentially.
particularly within CD4 + , CD8 + T-cell subsets. suggesting a lymphocyte-specific vulnerability.
-Mitochondrial dysfunction in PBMCs from activation of the intrinsic apoptotic pathway, characterized by mitochondrial membrane depolarization, an ⏫️ Bax/Bcl-2 ratio & elevated Caspase-3 activation
-Mitochondrial dysfunction in PBMCs from activation of the intrinsic apoptotic pathway, characterized by mitochondrial membrane depolarization, an ⏫️ Bax/Bcl-2 ratio & elevated Caspase-3 activation
November 6, 2025 at 5:37 AM
particularly within CD4 + , CD8 + T-cell subsets. suggesting a lymphocyte-specific vulnerability.
-Mitochondrial dysfunction in PBMCs from activation of the intrinsic apoptotic pathway, characterized by mitochondrial membrane depolarization, an ⏫️ Bax/Bcl-2 ratio & elevated Caspase-3 activation
-Mitochondrial dysfunction in PBMCs from activation of the intrinsic apoptotic pathway, characterized by mitochondrial membrane depolarization, an ⏫️ Bax/Bcl-2 ratio & elevated Caspase-3 activation
1/ Midterm gut check a year out. Assuming a D+4 generic ballot, I think Democrats are narrowly favored to take the House, even if the VRA is shredded. I think white college voters will continue to race towards Dems and racial depolarization is halted or reversed and this is pretty bad for the GOP.
November 5, 2025 at 8:39 PM
1/ Midterm gut check a year out. Assuming a D+4 generic ballot, I think Democrats are narrowly favored to take the House, even if the VRA is shredded. I think white college voters will continue to race towards Dems and racial depolarization is halted or reversed and this is pretty bad for the GOP.
Make them do the wave! When their arms are up, their sodium channel is open, and the excitement (depolarization) spreads across the classroom, but doesn’t go backwards because they’re tired from just having stood up and need a chance to reset.
They’ll roll their eyes, but they’ll remember!
They’ll roll their eyes, but they’ll remember!
November 5, 2025 at 1:35 PM
Make them do the wave! When their arms are up, their sodium channel is open, and the excitement (depolarization) spreads across the classroom, but doesn’t go backwards because they’re tired from just having stood up and need a chance to reset.
They’ll roll their eyes, but they’ll remember!
They’ll roll their eyes, but they’ll remember!
Andersen, M. K., Robertson, R. M., MacMillan, H. A. (2025). Temperature sensitivity of spreading depolarization in the CNS of Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol, 329(1):R134-r149 journals.physiology.org/doi/full/10....
November 4, 2025 at 7:40 PM
Andersen, M. K., Robertson, R. M., MacMillan, H. A. (2025). Temperature sensitivity of spreading depolarization in the CNS of Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol, 329(1):R134-r149 journals.physiology.org/doi/full/10....
21 eday strikes me as genuinely impossible because of vote method depolarization
November 3, 2025 at 6:35 PM
21 eday strikes me as genuinely impossible because of vote method depolarization
Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...
November 3, 2025 at 6:28 PM
Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) www.sciencedirect.com/science/arti...
Are we going to see more racial depolarization in favor of Reps? Is the Gen Z vote going to be ever more polarized along gender lines? The lack of Trump on the ballot is probably going to help this, but it’s not doing anything about the underlying trends. I just can’t see the backlash sticking.
November 3, 2025 at 5:10 PM
Are we going to see more racial depolarization in favor of Reps? Is the Gen Z vote going to be ever more polarized along gender lines? The lack of Trump on the ballot is probably going to help this, but it’s not doing anything about the underlying trends. I just can’t see the backlash sticking.
I like Klein and I find he is thoughtful and earnest enough to not deserve the kinds of heat he gets from the left, but he is obsessed by a retvrn to 1960s era party depolarization, and the consensus on liberalism, anti-communism, and racism it was built on is gone and should stay dead.
November 2, 2025 at 4:35 PM
I like Klein and I find he is thoughtful and earnest enough to not deserve the kinds of heat he gets from the left, but he is obsessed by a retvrn to 1960s era party depolarization, and the consensus on liberalism, anti-communism, and racism it was built on is gone and should stay dead.
Our joint research project on depolarization now has a little web description! www.wiso.uni-hamburg.de/en/fachberei...
DEveloping POLARIZation Interventions based on Empathy
www.wiso.uni-hamburg.de
November 2, 2025 at 2:30 PM
Our joint research project on depolarization now has a little web description! www.wiso.uni-hamburg.de/en/fachberei...
Voltage-gated calcium channels allow Ca++ influx following membrane depolarization. The channel complex consists of several subunits:
The red forms the central pore through which Ca++ ions pass.
The extracellular and intracellular proteins regulate channel activation and inactivation.
The red forms the central pore through which Ca++ ions pass.
The extracellular and intracellular proteins regulate channel activation and inactivation.
November 1, 2025 at 7:00 PM
Voltage-gated calcium channels allow Ca++ influx following membrane depolarization. The channel complex consists of several subunits:
The red forms the central pore through which Ca++ ions pass.
The extracellular and intracellular proteins regulate channel activation and inactivation.
The red forms the central pore through which Ca++ ions pass.
The extracellular and intracellular proteins regulate channel activation and inactivation.
For this reason, *depolarization*, i.e. the reunification of left and right political groups that have long been at odds, could be an apocalyptically bad outcome for some people. Probably it wouldn't be, but we really shouldn't be invested in the polarization-is-bad narrative.
November 1, 2025 at 12:13 AM
For this reason, *depolarization*, i.e. the reunification of left and right political groups that have long been at odds, could be an apocalyptically bad outcome for some people. Probably it wouldn't be, but we really shouldn't be invested in the polarization-is-bad narrative.
Some depolarization of voting method, maybe?
October 31, 2025 at 10:51 PM
Some depolarization of voting method, maybe?
This is why we need ideological depolarization. Retvrn to conservative Dems and liberal Republicans being sizable factions in their parties.
I'm doing my part as a pro-free market, pro-military, pro-law and order guy who is registered as a Dem.
I'm doing my part as a pro-free market, pro-military, pro-law and order guy who is registered as a Dem.
October 30, 2025 at 8:54 PM
This is why we need ideological depolarization. Retvrn to conservative Dems and liberal Republicans being sizable factions in their parties.
I'm doing my part as a pro-free market, pro-military, pro-law and order guy who is registered as a Dem.
I'm doing my part as a pro-free market, pro-military, pro-law and order guy who is registered as a Dem.
Lasting depolarization won't come from asking individuals to be better; it will come from re-engineering the system that rewards being worse. We must deal with the dynamical feedback between “elites” and masses.
October 30, 2025 at 3:00 PM
Lasting depolarization won't come from asking individuals to be better; it will come from re-engineering the system that rewards being worse. We must deal with the dynamical feedback between “elites” and masses.
The average effect of depolarization treatments is modest at best (“a 5.4-point shift on a 101-point scale”) and decays within 2 weeks. Even more discouragingly, "stacking" multiple interventions or repeating them as "booster shots" doesn't produce significantly larger or more durable results.
October 30, 2025 at 3:00 PM
The average effect of depolarization treatments is modest at best (“a 5.4-point shift on a 101-point scale”) and decays within 2 weeks. Even more discouragingly, "stacking" multiple interventions or repeating them as "booster shots" doesn't produce significantly larger or more durable results.
Many depolarization programs highlight the importance of acknowledging common ground, often assuming that democratic values are something we can all agree on. This paper underscores why that's a bad assumption—and how support for multiracial pluralistic democracy is itself related to group identity.
This is a form of social prejudice that @svmiller.com and I find is empirically associated with weak support for democracy. (Will link paper below.) We’ve stalled on the book project but we document that anti-neighbor prejudice of this nature is corrosive to democratic values.
Vance says it is "totally reasonable and acceptable" for people to not want to live next door to people who speak a different language than they do
October 30, 2025 at 2:10 PM
Many depolarization programs highlight the importance of acknowledging common ground, often assuming that democratic values are something we can all agree on. This paper underscores why that's a bad assumption—and how support for multiracial pluralistic democracy is itself related to group identity.