#VascularCalcification
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haoyin.bsky.social
#VascularCalcification #SmoothMuscleCell m6A Epitranscriptomics

High Pi ⏬METTL3 in SMCs

METTL3-YTHDF2 destabilizes RUNX2 mRNA & ⏬ SMC Osteogenesis

S-Adenosylhomocysteine METTL3/14i aggravates aortic calcification in CKD 🐭 (adenine + hi Pi diet)

#CommsBio 2025
www.nature.com/articles/s42...
November 4, 2025 at 8:04 PM
febsopenbio.bsky.social
Diabetes-induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

➡️ buff.ly/bs13bDz

#Diabetes #VascularCalcification #Pyrophosphate
October 28, 2025 at 10:15 AM
haoyin.bsky.social
#VascularCalcification Mechanobiology

#HydrostaticPressure 120 mmHg 7 d➡️
⏫#Piezo1➡️ (⏫ #ERStress GPR78 CHOP➡️)
⏫ #SmoothMuscleCell Calcification (~20% level by 4 mM Pi)

#BBAMolBasisDis 2025
www.sciencedirect.com/science/arti...
October 20, 2025 at 11:33 AM
haoyin.bsky.social
#vascularCalcification

DNA N6-methyladenine/6mA (NOT m6A) of BMP2 gene ⏬OCT4-dependent transcription & #SmoothMuscleCell Calcification

ALKBH1, an eraser of 6mA
⬇️in calcified radial artery of👤CKD
⏫aortic calcification in 🐭+Adenine diet

@jci.org 2021
www.jci.org/articles/vie...
October 12, 2025 at 6:58 PM
sigtrans-sttt.bsky.social
#LINE1 drives #VascularCalcification (VC) via cGAS-STING–mediated #inflammation, and silencing LINE1 or treating with #NRTIs suppresses VSMC osteogenic reprogramming, reduces VC in mice, and lowers VC incidence in humans. #medsky

#OpenAccess in #STTT: doi.org/10.1038/s413...
October 7, 2025 at 11:01 PM
haoyin.bsky.social
#VascularCalcification

#SmoothMuscleCell NAMPT-SIRT1 axis, via suppressing Notch-HES1 signaling, protects against aortic medial calcification in 🐭VitD3 or CKD

#ATVB 2025 @ahajournals.bsky.social
www.ahajournals.org/doi/10.1161/...
September 12, 2025 at 12:23 PM
sthilaire.bsky.social
That happy feeling when someone features a graphic you made in their talk 😇 #ASBMR2025 #vascularcalcification #ACDCmedical #MAC
September 4, 2025 at 10:08 PM
drjenniexu.bsky.social
Chronic Kidney Disease—Mineral and Bone Disorder (CKD-MBD), from Bench to Bedside

#OpenAccess
Full text 👉https://buff.ly/XY11LOV

#CKD
#KidneyHealth
#Dialysis
#BoneDisorder
#VascularCalcification
#Nephrology
#KidneyCare
#nephsky
#medsky
August 13, 2025 at 12:23 AM
haoyin.bsky.social
#VascularCalcification

#Glutaminase1 (GLS1)-derived Glutamate drives #SmoothMuscleCell #Osteogenesis via NMDAR (▶️Ca2+/β-at), not AMPAR, mGlu

Both GLS1 & NMDAR ⏫in 👤calcified arteries #CKD

BPTES (GLS1i)⏬🐭arterial calcification (VitD3)

#AdvSci 2025
advanced.onlinelibrary.wiley.com/doi/10.1002/...
August 2, 2025 at 1:36 PM
febsopenbio.bsky.social
Gut alterations in a chronic kidney disease rat model with diet-induced vascular calcification

👉 buff.ly/ZkuYVrB

#ChronicKidneyDisease #VascularCalcification
June 27, 2025 at 9:22 AM
haoyin.bsky.social
#EndothelialCell to #SmoothMuscleCell communications in #VascularCalcification

CPP2, secondary calciprotein crystalline nanoaggregate, is internalized by EC(▶️Inflammation + altered secretome) & SMC (▶️calcification w/o osteogenic reprogram RUNX2 in 24 h)

#CMLS 2025
link.springer.com/article/10.1...
June 17, 2025 at 8:21 PM
haoyin.bsky.social
How does Genomic Instability cause #VascularCalcification?

A potential STING-STAT1-NLRP3 #Inflammasome cascade in #SmoothMuscleCell Osteogenesis #MedialArterialCacification

Which type of DNA lesions activates STING in calcifying SMC?🧐

#FASEBJ 2025
faseb.onlinelibrary.wiley.com/doi/10.1096/...
April 10, 2025 at 6:53 PM
haoyin.bsky.social
Endothelial-to-Mesenchymal Transition in Cardiovascular Pathophysiology
#EndMT

#Atherosclerosis
#VascularCalcification
#PeripheralArteryDisease
#PulmonaryHypertension
#ValvularHeartDisease
#MyocardialInfarction
#CardiacFibrosis

Krishna Singh lab #IJMS_MDPI 2024
www.mdpi.com/1422-0067/25...
March 24, 2025 at 11:28 AM
haoyin.bsky.social
DJ-1/PARK7 (causal gene of #ParkinsonDisease)⏬Diabetic #VascularCalcification

Acetylation (by NAT10)-Ubiquitination (by TRIM32) cascade degrades DJ-1▶️
⏫STAT1 & RAGE
⏫#SmoothMuscleCell Osteogenesis
⏫SMC MFGE8+ #MatrixVesicle▶️
⏫MV-collagen binding

#CardiovascRes 2024
academic.oup.com/cardiovascre...
February 10, 2025 at 12:34 PM
haoyin.bsky.social
#LaminarShearStress-KLF2 in #EndothelialCell ⏬BMP signaling ▶️⏬#VascularCalcification in hyperlipidemic🐭

BMP4 BMPER as direct targets of KLF2

LSS
⏫BMPER
⏬BMP4 MGP FST

OsteoSense 680 to image aortic calcification in vivo

#CircRes 2021 @ahascience.bsky.social

www.ahajournals.org/doi/10.1161/...
November 23, 2024 at 8:24 PM
haoyin.bsky.social
#SIRT7 protects against VitD3-induced🐭#VascularCalcification

SIRT7 does Not directly modify osteogenic factors RUNX2/BMP2 or contractile markers in 🐭aortic #SmoothMuscleCell +high Pi
Instead, SIRT7 appears antioxidant & anti-senescent

#FreeRadicBiolMed 2024
www.sciencedirect.com/science/arti...
August 9, 2024 at 7:28 PM
haoyin.bsky.social
#PCSK9 #VascularCalcification

50%⏫plasma PCSK9 in👤CKD+atherosclerotic calcification n=104 vs 330 Ctrl

300%⏫plasma PCSK9 in uremic rats
kidney as a PCSK9 source

#SmoothMuscleCell+PCSK9 OE secretes⏫calcific #ExtracellularVesicle

#Atherosclerosis 2022
www.atherosclerosis-journal.com/article/S002...
January 3, 2024 at 8:26 PM
kateisabelle24.bsky.social
@JenniferLees85 presents her work on #vascularcalcification & #vitaminK @Jamietraynor01 @drpaddymark @Kidney_Research @UofGICAMS #eraedta18
November 16, 2024 at 10:37 PM