Join us for tomorrow's #comp #IO webinar: Using Spatial Biology to Monitor Tumor Immune Interactions. Review methods for extracting information on the tumor immune microenvironment from spatial imaging and spatial genomics assays!
Register: https://www.sitcancer.org/edu/webinars/computational
Register: https://www.sitcancer.org/edu/webinars/computational
November 12, 2025 at 4:02 PM
Join us for tomorrow's #comp #IO webinar: Using Spatial Biology to Monitor Tumor Immune Interactions. Review methods for extracting information on the tumor immune microenvironment from spatial imaging and spatial genomics assays!
Register: https://www.sitcancer.org/edu/webinars/computational
Register: https://www.sitcancer.org/edu/webinars/computational
Sellist 💩 jagab Eesti tervisekassa lepinguline perearst ⚠️Helen Lasn, kes saab palka maksumaksja taskust
🩺🤡☠️
Patsiendi kaitsmine on jätkuvalt patsiendi enese asi.
Äkki võtaks kõigi nende aastate järel viimaks midagi ette, et hea doktor saaks pühenduda oma armastatud Zinzino võrkturundusele?
🩺🤡☠️
Patsiendi kaitsmine on jätkuvalt patsiendi enese asi.
Äkki võtaks kõigi nende aastate järel viimaks midagi ette, et hea doktor saaks pühenduda oma armastatud Zinzino võrkturundusele?
November 12, 2025 at 4:17 AM
Sellist 💩 jagab Eesti tervisekassa lepinguline perearst ⚠️Helen Lasn, kes saab palka maksumaksja taskust
🩺🤡☠️
Patsiendi kaitsmine on jätkuvalt patsiendi enese asi.
Äkki võtaks kõigi nende aastate järel viimaks midagi ette, et hea doktor saaks pühenduda oma armastatud Zinzino võrkturundusele?
🩺🤡☠️
Patsiendi kaitsmine on jätkuvalt patsiendi enese asi.
Äkki võtaks kõigi nende aastate järel viimaks midagi ette, et hea doktor saaks pühenduda oma armastatud Zinzino võrkturundusele?
Online now: The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes
Tu et al. present a systematic analysis of the tumor microenvironment across 14,837 breast cancers, identifying distinct cellular patterns that predict disease-specific survival independently of genomic and intrinsic subtypes. Characterizing microenvironment composition may provide critical prognostic markers that can complement current molecular classification for treatment selection and preventing recurrence.
dlvr.it
November 11, 2025 at 8:19 PM
Online now: The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
November 11, 2025 at 6:21 PM
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
@caldaslab.bsky.social rocks!
@ims-mrl.bsky.social
@hebrewuniversity.bsky.social
@lautenbergc.bsky.social
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes: Cell Reports Medicine www.cell.com/cell-reports...
@ims-mrl.bsky.social
@hebrewuniversity.bsky.social
@lautenbergc.bsky.social
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes: Cell Reports Medicine www.cell.com/cell-reports...
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes
Tu et al. present a systematic analysis of the tumor microenvironment across 14,837
breast cancers, identifying distinct cellular patterns that predict disease-specific
survival independently of genom...
www.cell.com
November 10, 2025 at 6:57 PM
@caldaslab.bsky.social rocks!
@ims-mrl.bsky.social
@hebrewuniversity.bsky.social
@lautenbergc.bsky.social
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes: Cell Reports Medicine www.cell.com/cell-reports...
@ims-mrl.bsky.social
@hebrewuniversity.bsky.social
@lautenbergc.bsky.social
The tumor microenvironment of 14,837 breast cancers is associated with clinical outcome independently of genomic subtypes: Cell Reports Medicine www.cell.com/cell-reports...
Aging Tumor Microenvironment Fuels Cancer Risk: Genetic and Epigenetic Changes Elevate Clonal Expansion Post-50, Paving Path for New Therapies.
by Easwaran H and Weeraratna AT in Nat Rev Cancer #MedSky
👉 get more here
📖 read the article:
by Easwaran H and Weeraratna AT in Nat Rev Cancer #MedSky
👉 get more here
📖 read the article:
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer - Nature Reviews Cancer
In this Review, Easwaran and Weeraratna outline how ageing leads to epigenetic alterations in the tissue microenvironment, enhancing clonal expansion of mutations and ultimately increasing cancer risk.
www.nature.com
November 10, 2025 at 6:43 PM
We found that tumor–microenvironment interactions significantly shape chemotherapy response, depending on ER subtype. ER– tumors relied more on mature, adaptive immune cells, while ER+ tumors showed a more innate/early-adaptive response pattern.
November 10, 2025 at 5:24 PM
We found that tumor–microenvironment interactions significantly shape chemotherapy response, depending on ER subtype. ER– tumors relied more on mature, adaptive immune cells, while ER+ tumors showed a more innate/early-adaptive response pattern.
We identified 7 distinct tumor microenvironment (“TME”) Types that capture immune, stromal, and vascular patterns, normalized for tumor cellularity. The TME Types independently predicted disease-specific survival beyond genomic and intrinsic subtype.
November 10, 2025 at 5:24 PM
We identified 7 distinct tumor microenvironment (“TME”) Types that capture immune, stromal, and vascular patterns, normalized for tumor cellularity. The TME Types independently predicted disease-specific survival beyond genomic and intrinsic subtype.
We first benchmarked 15 tumor microenvironment deconvolution methods in 693 breast cancers with matched imaging mass cytometry from the METABRIC cohort. InstaPrism (cousin of BayesPrism) consistently performed best—so we used it for the full 14,837-sample cohort.
November 10, 2025 at 5:24 PM
We first benchmarked 15 tumor microenvironment deconvolution methods in 693 breast cancers with matched imaging mass cytometry from the METABRIC cohort. InstaPrism (cousin of BayesPrism) consistently performed best—so we used it for the full 14,837-sample cohort.
We created a meta-cohort of 14,837 breast cancers with clinically annotated RNA-seq data. Using deconvolution, we asked whether the tumor microenvironment could predict outcomes independently of genomic and intrinsic subtype.
November 10, 2025 at 5:24 PM
We created a meta-cohort of 14,837 breast cancers with clinically annotated RNA-seq data. Using deconvolution, we asked whether the tumor microenvironment could predict outcomes independently of genomic and intrinsic subtype.
The tumor microenvironment—the non-cancerous part of a tumor—plays a major role in patient outcomes and treatment response, yet it’s rarely examined in the clinic.
We asked: can characterizing the microenvironment be clinically useful if done on top of current tumor subtyping?
We asked: can characterizing the microenvironment be clinically useful if done on top of current tumor subtyping?
November 10, 2025 at 5:24 PM
The tumor microenvironment—the non-cancerous part of a tumor—plays a major role in patient outcomes and treatment response, yet it’s rarely examined in the clinic.
We asked: can characterizing the microenvironment be clinically useful if done on top of current tumor subtyping?
We asked: can characterizing the microenvironment be clinically useful if done on top of current tumor subtyping?
My poor laptop wishes I learned how to use the cluster earlier, but it’s sacrifice was not in vain! We learned some important things about the breast cancer tumor microenvironment, described in our paper published today:
www.cell.com/cell-reports...
Here's the 🧵
www.cell.com/cell-reports...
Here's the 🧵
November 10, 2025 at 5:24 PM
My poor laptop wishes I learned how to use the cluster earlier, but it’s sacrifice was not in vain! We learned some important things about the breast cancer tumor microenvironment, described in our paper published today:
www.cell.com/cell-reports...
Here's the 🧵
www.cell.com/cell-reports...
Here's the 🧵
How does the tumor microenvironment change as cancer progresses - & which cells appear, persist, or disappear along the way?
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Study reveals dynamics of breast tumor microenvironment over time | Johanna Joyce posted on the topic | LinkedIn
How does the tumor microenvironment change as cancer progresses — and which cells appear, persist, or disappear along the way?
In this new study, a wonderful collaboration with Jean Hausser and his l...
www.linkedin.com
November 10, 2025 at 3:06 PM
How does the tumor microenvironment change as cancer progresses - & which cells appear, persist, or disappear along the way?
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Excited to share our new study on the #TME answering this question!
Great collaboration with the Hausser lab 🧪🧬🔬
Open access link: www.cell.com/iscience/ful...
Read more ⏬
Researchers led by Ludwig @unil.bsky.social’s @johannajoyce.bsky.social, Spenser Watson and alumnus Jean Hausser have captured the temporal cellular dynamics of the tumor microenvironment over four weeks following tumor induction in a mouse model of breast cancer. bit.ly/4nCzA59
#CanSky #OncoSky
#CanSky #OncoSky
November 10, 2025 at 2:59 PM
Researchers led by Ludwig @unil.bsky.social’s @johannajoyce.bsky.social, Spenser Watson and alumnus Jean Hausser have captured the temporal cellular dynamics of the tumor microenvironment over four weeks following tumor induction in a mouse model of breast cancer. bit.ly/4nCzA59
#CanSky #OncoSky
#CanSky #OncoSky
Webinar on Tumor Microenvironment: A Game Changer for Cancer Research and Drug Discovery#Canada#Toronto#Cancer_Research#Tumor_Microenvironment#Xtalks
Webinar on Tumor Microenvironment: A Game Changer for Cancer Research and Drug Discovery
Join the upcoming Xtalks webinar to explore innovative strategies for modeling the tumor microenvironment and advancing cancer research.
third-news.com
November 10, 2025 at 1:50 PM
Webinar on Tumor Microenvironment: A Game Changer for Cancer Research and Drug Discovery#Canada#Toronto#Cancer_Research#Tumor_Microenvironment#Xtalks
This research paper explores the dual roles of tumor-associated macrophages (TAMs) in the tumor microenvironment.
November 10, 2025 at 1:03 PM
This research paper explores the dual roles of tumor-associated macrophages (TAMs) in the tumor microenvironment.
Tumor-associated macrophages (TAMs) play a dual role in the tumor microenvironment - pro-inflammatory M1 TAMs fight cancer, while pro-tumor M2 TAMs promote angiogenesis, metastasis, and i...
🧵 Thread below
Full analysis: https://helixbrief.com/article/2102383d-07d6-4046-87ec-d779e5f0ba7a
🧵 Thread below
Full analysis: https://helixbrief.com/article/2102383d-07d6-4046-87ec-d779e5f0ba7a
November 10, 2025 at 1:03 PM
Tumor-associated macrophages (TAMs) play a dual role in the tumor microenvironment - pro-inflammatory M1 TAMs fight cancer, while pro-tumor M2 TAMs promote angiogenesis, metastasis, and i...
🧵 Thread below
Full analysis: https://helixbrief.com/article/2102383d-07d6-4046-87ec-d779e5f0ba7a
🧵 Thread below
Full analysis: https://helixbrief.com/article/2102383d-07d6-4046-87ec-d779e5f0ba7a
Both drugs have a cleavable linker that allows the MMAE payload (💣) to be cleaved off in the tumor microenvironment.
November 10, 2025 at 12:06 AM
Both drugs have a cleavable linker that allows the MMAE payload (💣) to be cleaved off in the tumor microenvironment.
Both drugs have a cleavable linker that allows the MMAE payload (💣) to be cleaved off in the tumor microenvironment.
November 10, 2025 at 12:05 AM
Both drugs have a cleavable linker that allows the MMAE payload (💣) to be cleaved off in the tumor microenvironment.
Wen et al. review how YTHDF proteins regulate tumor responses to #radiotherapy by modulating DNA repair & the immune microenvironment, and discuss their potential as therapeutic targets. rupress.org/jem/article/...
📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 8, 2025 at 3:15 PM
Wen et al. review how YTHDF proteins regulate tumor responses to #radiotherapy by modulating DNA repair & the immune microenvironment, and discuss their potential as therapeutic targets. rupress.org/jem/article/...
📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
📘 In #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
A team has mapped the tumor microenvironment of HPV-associated penile cancer at single-cell resolution. The study, published in Precision Clinical Medicine in September 2025, analyzed 52,980 single cells from 11 treatment-naïve PSCC patients.
#human papillomavirus
Details: doi.org/10.1093/pcme...
#human papillomavirus
Details: doi.org/10.1093/pcme...
November 8, 2025 at 7:06 AM
A team has mapped the tumor microenvironment of HPV-associated penile cancer at single-cell resolution. The study, published in Precision Clinical Medicine in September 2025, analyzed 52,980 single cells from 11 treatment-naïve PSCC patients.
#human papillomavirus
Details: doi.org/10.1093/pcme...
#human papillomavirus
Details: doi.org/10.1093/pcme...
These findings indicate that tissue boundaries can serve as targetable mechanisms in metastatic progression, providing insights into the complex interplay between the tumor microenvironment and cancer cell behavior.
November 8, 2025 at 6:05 AM
These findings indicate that tissue boundaries can serve as targetable mechanisms in metastatic progression, providing insights into the complex interplay between the tumor microenvironment and cancer cell behavior.
Today at #SITC2025:
Get a first look at how MERFISH 2.0™ data generated on MERSCOPE Ultra™ is combined with InSituPlex® multiplex immunofluorescence on sequential sections to decode the tumor–immune microenvironment.
12:15-1:45 p.m. & 5:35-7 p.m.
#SpatialBiology #SpatialMultiOmics
Get a first look at how MERFISH 2.0™ data generated on MERSCOPE Ultra™ is combined with InSituPlex® multiplex immunofluorescence on sequential sections to decode the tumor–immune microenvironment.
12:15-1:45 p.m. & 5:35-7 p.m.
#SpatialBiology #SpatialMultiOmics
November 7, 2025 at 4:05 PM
Today at #SITC2025:
Get a first look at how MERFISH 2.0™ data generated on MERSCOPE Ultra™ is combined with InSituPlex® multiplex immunofluorescence on sequential sections to decode the tumor–immune microenvironment.
12:15-1:45 p.m. & 5:35-7 p.m.
#SpatialBiology #SpatialMultiOmics
Get a first look at how MERFISH 2.0™ data generated on MERSCOPE Ultra™ is combined with InSituPlex® multiplex immunofluorescence on sequential sections to decode the tumor–immune microenvironment.
12:15-1:45 p.m. & 5:35-7 p.m.
#SpatialBiology #SpatialMultiOmics
@kepauken.bsky.social, Sharpe et al. show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...
📘 #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
📘 #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
November 7, 2025 at 3:15 PM
@kepauken.bsky.social, Sharpe et al. show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...
📘 #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25
📘 #cancer #immunotherapy collection: rupress.org/jem/collecti...
#SITC25