Attending a fascinating talk by
Prof Begona Heras on “Structural insights into the function and inhibition of bacterial virulence proteins. “
Looking for overlaps with methods we are putting together in the Structural Phylogenetics space. #StrPhy #StructuralPhylogenetics @strphy.bsky.social
Prof Begona Heras on “Structural insights into the function and inhibition of bacterial virulence proteins. “
Looking for overlaps with methods we are putting together in the Structural Phylogenetics space. #StrPhy #StructuralPhylogenetics @strphy.bsky.social
October 15, 2025 at 2:05 AM
Attending a fascinating talk by
Prof Begona Heras on “Structural insights into the function and inhibition of bacterial virulence proteins. “
Looking for overlaps with methods we are putting together in the Structural Phylogenetics space. #StrPhy #StructuralPhylogenetics @strphy.bsky.social
Prof Begona Heras on “Structural insights into the function and inhibition of bacterial virulence proteins. “
Looking for overlaps with methods we are putting together in the Structural Phylogenetics space. #StrPhy #StructuralPhylogenetics @strphy.bsky.social
Future work 1) inclusion of custom structure search 2) and I am working on digesting large scale text data via LLMs to offer meaningful text-based insights per query.
Feedback requested:
What would you improve?
#Structome #StructuralPhylogenetics #Science
Feedback requested:
What would you improve?
#Structome #StructuralPhylogenetics #Science
February 8, 2025 at 9:19 PM
Future work 1) inclusion of custom structure search 2) and I am working on digesting large scale text data via LLMs to offer meaningful text-based insights per query.
Feedback requested:
What would you improve?
#Structome #StructuralPhylogenetics #Science
Feedback requested:
What would you improve?
#Structome #StructuralPhylogenetics #Science
New in the #StructuralPhylogenetics special section:
Dixson et al. show that structural and physicochemical features of proteins uncover remote evolutionary relationships and provide a new toolset to revisit mitochondrial enzyme evolution.
@genomebiolevol.bsky.social
Dixson et al. show that structural and physicochemical features of proteins uncover remote evolutionary relationships and provide a new toolset to revisit mitochondrial enzyme evolution.
@genomebiolevol.bsky.social
Inference of Cytochrome P450 Evolutionary History Using Structural and Physicochemical Metrics
Abstract. Cytochrome P450s are a superfamily of heme-binding monooxygenases involved with the detoxification of intrinsic and extrinsic toxins. They are ne
academic.oup.com
October 15, 2025 at 10:52 PM
New in the #StructuralPhylogenetics special section:
Dixson et al. show that structural and physicochemical features of proteins uncover remote evolutionary relationships and provide a new toolset to revisit mitochondrial enzyme evolution.
@genomebiolevol.bsky.social
Dixson et al. show that structural and physicochemical features of proteins uncover remote evolutionary relationships and provide a new toolset to revisit mitochondrial enzyme evolution.
@genomebiolevol.bsky.social
August 22, 2025 at 12:20 PM
#structuralphylogenetics #strphylo #proteins #evolution
Great example of what protein 3D structures can tell us about evolution and the origin of eukaryotes
Great example of what protein 3D structures can tell us about evolution and the origin of eukaryotes
🧵In collaboration with Caroline Puente-Lelievre, Ed Moody, Rosie Cater, and Tom Williams we just submitted a new paper describing the prokaryotic origins of the COMMD protein family. @cpuentelelievre.bsky.social, @rosemaryjcater.bsky.social. @kmichie.bsky.social. 1/n
The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking
The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...
www.biorxiv.org
September 3, 2025 at 1:44 AM
#structuralphylogenetics #strphylo #proteins #evolution
Great example of what protein 3D structures can tell us about evolution and the origin of eukaryotes
Great example of what protein 3D structures can tell us about evolution and the origin of eukaryotes
Structome-TM preprint now live @ www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
#Science #Structome #StructuralPhylogenetics
@biorxivpreprint.bsky.social
#Science #Structome #StructuralPhylogenetics
Structome-TM: Complementing dataset assembly for structural phylogenetics by addressing size-based biases
The increasing availability of protein structures presents new opportunities for detecting homologous proteins. While global alignment methods are widely used and generally effective, they often strug...
www.biorxiv.org
February 8, 2025 at 9:10 PM
Structome-TM preprint now live @ www.biorxiv.org/content/10.1...
@biorxivpreprint.bsky.social
#Science #Structome #StructuralPhylogenetics
@biorxivpreprint.bsky.social
#Science #Structome #StructuralPhylogenetics
We’ve set up a dedicated Bluesky space for structural phylogenetics: @strphy.bsky.social. Follow for community updates.
#StrPhy #StructuralPhylogenetics
#StrPhy #StructuralPhylogenetics
October 9, 2025 at 4:04 AM
We’ve set up a dedicated Bluesky space for structural phylogenetics: @strphy.bsky.social. Follow for community updates.
#StrPhy #StructuralPhylogenetics
#StrPhy #StructuralPhylogenetics