Still no way close to finding out what is going on with my heart problems but the retatrutide has definitely done a body good 😊
November 11, 2025 at 1:40 PM
Still no way close to finding out what is going on with my heart problems but the retatrutide has definitely done a body good 😊
I'm recently back on Retatrutide and it's had several benefits I immediately recognized again.
I'm gonna need folks to understand that just because the worst people in America are obsessed with GLP-1s exclusively because of weight loss does not mean they are not LIFE SAVING for a lot of people.
There's a reason they're studying their impact on Long Covid right now.
There's a reason they're studying their impact on Long Covid right now.
November 6, 2025 at 8:36 PM
I'm recently back on Retatrutide and it's had several benefits I immediately recognized again.
Who can 3D print me a retatrutide molecule for my desk? 😁
November 6, 2025 at 5:09 PM
Who can 3D print me a retatrutide molecule for my desk? 😁
Yeah, they've also lost the technical edge on both the pill and the most effective GLP-1(Lilly's Retatrutide) so there's not much there for them
November 6, 2025 at 10:02 PM
Yeah, they've also lost the technical edge on both the pill and the most effective GLP-1(Lilly's Retatrutide) so there's not much there for them
Not me banging the drums LOUDLY the last year or so, SURPASS CVOT was remarkable. Retatrutide is going to be even better
Heck on a renal note, Boheringer Ingelheim is following in Lilly's footsteps and checking to see if the GFR rise with their GLP1/GCG agonist survodutide is real too!
Heck on a renal note, Boheringer Ingelheim is following in Lilly's footsteps and checking to see if the GFR rise with their GLP1/GCG agonist survodutide is real too!
November 4, 2025 at 1:17 AM
Not me banging the drums LOUDLY the last year or so, SURPASS CVOT was remarkable. Retatrutide is going to be even better
Heck on a renal note, Boheringer Ingelheim is following in Lilly's footsteps and checking to see if the GFR rise with their GLP1/GCG agonist survodutide is real too!
Heck on a renal note, Boheringer Ingelheim is following in Lilly's footsteps and checking to see if the GFR rise with their GLP1/GCG agonist survodutide is real too!
Many of my followers know I'm an absolute retatrutide fanboy. I was on the drug in trial, it changed my life forever. It did something funny to my kidney function. It raised my GFR about 20% in 19 months as seen below Pick a measure it rose. Lilly noticed this too and started a trial looking it 🧵
October 30, 2025 at 11:26 PM
Many of my followers know I'm an absolute retatrutide fanboy. I was on the drug in trial, it changed my life forever. It did something funny to my kidney function. It raised my GFR about 20% in 19 months as seen below Pick a measure it rose. Lilly noticed this too and started a trial looking it 🧵
This paragraph is the money shot of what I think is what retatrutide is probably doing. Modulating lipids(⬆️ ketones) and modulating the RAAS system through the macula dense(which has glucagon receptors)
October 30, 2025 at 11:26 PM
This paragraph is the money shot of what I think is what retatrutide is probably doing. Modulating lipids(⬆️ ketones) and modulating the RAAS system through the macula dense(which has glucagon receptors)
Enter TRANSCEND-CKD. As the graphic below shows this is a trial of retatrutide in diabetics and non diabetics with CKD. And Lilly spared NO expense on this trial. This pre-print details just how extensive they are studying the kidney. This is gonna be a deep dive so hold on #NephSky #NephJC
October 30, 2025 at 11:26 PM
Exploratory points include the effect of retatrutide to placebo for the change from baseline to Week 16 and to Week 24 in kidney and abdominal adipose tissue, and renal diffusion, assessed using non-invasive, multimodal MRI techniques, and creatinine- and cystatin C eGFR
WHEW
Ain't done yet!
WHEW
Ain't done yet!
a man is standing in front of a shelf full of oxi clean
ALT: a man is standing in front of a shelf full of oxi clean
media.tenor.com
October 30, 2025 at 11:26 PM
Exploratory points include the effect of retatrutide to placebo for the change from baseline to Week 16 and to Week 24 in kidney and abdominal adipose tissue, and renal diffusion, assessed using non-invasive, multimodal MRI techniques, and creatinine- and cystatin C eGFR
WHEW
Ain't done yet!
WHEW
Ain't done yet!
Now open access in @ndt-era.bsky.social
Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in pts with CKD
🧐Retatrutide is a novel triple incretin agonist targeting GIP, GLP-1, and glucagon receptors
▶️ academic.oup.com/ndt/article/...
Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in pts with CKD
🧐Retatrutide is a novel triple incretin agonist targeting GIP, GLP-1, and glucagon receptors
▶️ academic.oup.com/ndt/article/...
October 30, 2025 at 8:56 AM
Now open access in @ndt-era.bsky.social
Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in pts with CKD
🧐Retatrutide is a novel triple incretin agonist targeting GIP, GLP-1, and glucagon receptors
▶️ academic.oup.com/ndt/article/...
Rationale, Design, and Baseline Characteristics of the TRANSCEND-CKD trial of Retatrutide in pts with CKD
🧐Retatrutide is a novel triple incretin agonist targeting GIP, GLP-1, and glucagon receptors
▶️ academic.oup.com/ndt/article/...
In what I can only describe as foreshadowing for retatrutide in a few months, Mazdutide(dual GLP1/glucagon agonist) caused 10.3% weight loss in only 32 weeks vs semaglutide. That's impressive loss. And 48% of patient had A1c <7 and >10% weight loss. Most impressive!
Innovent's Mazdutide Shows Superiority in Glycemic Control with Weight Loss over Semaglutide in a Head-to-head Phase 3 Clinical Trial DREAMS-3
/PRNewswire/ -- Innovent Biologics, Inc. ("Innovent") (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes...
www.prnewswire.com
October 27, 2025 at 2:45 PM
In what I can only describe as foreshadowing for retatrutide in a few months, Mazdutide(dual GLP1/glucagon agonist) caused 10.3% weight loss in only 32 weeks vs semaglutide. That's impressive loss. And 48% of patient had A1c <7 and >10% weight loss. Most impressive!
This mRNA result is spectacular. It reminds me of this less heralded result with retatrutide slowed down cancer progression for also complicated and unexpected ways. This was in lung and pancreatic cancers.
October 25, 2025 at 4:49 PM
This mRNA result is spectacular. It reminds me of this less heralded result with retatrutide slowed down cancer progression for also complicated and unexpected ways. This was in lung and pancreatic cancers.
A quick and dirty chart illustrating my weight loss since I started the Retatrutide study and the trend since I had to stop dosing back on 8/8. High was 349.4. Low was 160.7 on 7/7. Current is 181.8 lbs.
October 23, 2025 at 5:52 PM
A quick and dirty chart illustrating my weight loss since I started the Retatrutide study and the trend since I had to stop dosing back on 8/8. High was 349.4. Low was 160.7 on 7/7. Current is 181.8 lbs.
Another retatrutide trial patient with incredible results this time a diabetic over 10 months...
A1c down to 5.3%
Weight down 21% (70lbs!) and no plateau yet.
Off one hypertension med, and reduced dose of 2nd.
And then the kidney function changes...
A1c down to 5.3%
Weight down 21% (70lbs!) and no plateau yet.
Off one hypertension med, and reduced dose of 2nd.
And then the kidney function changes...
October 21, 2025 at 2:32 PM
Another retatrutide trial patient with incredible results this time a diabetic over 10 months...
A1c down to 5.3%
Weight down 21% (70lbs!) and no plateau yet.
Off one hypertension med, and reduced dose of 2nd.
And then the kidney function changes...
A1c down to 5.3%
Weight down 21% (70lbs!) and no plateau yet.
Off one hypertension med, and reduced dose of 2nd.
And then the kidney function changes...
So for #Nephsky help me understand a few things about this retatrutide CKD study. I understand a few of the labs(UACR, 24 hr electrolytes and radiology outcomes) but if retatrutide does actually help increase GFR without hyperfiltration how would FENa change? What would the various MRI changes mean?
October 19, 2025 at 8:47 PM
So for #Nephsky help me understand a few things about this retatrutide CKD study. I understand a few of the labs(UACR, 24 hr electrolytes and radiology outcomes) but if retatrutide does actually help increase GFR without hyperfiltration how would FENa change? What would the various MRI changes mean?
I think my glycogen levels dropping due to the retatrutide is what's causing my fatigue because once I eat I feel much better 🪿
October 16, 2025 at 5:42 PM
I think my glycogen levels dropping due to the retatrutide is what's causing my fatigue because once I eat I feel much better 🪿
So I've had to stop training altogether due to fatigue which is difficult tbh however the retatrutide does seem to be working as my love handles have shrank quite significantly and I only had my first jab on Saturday so that's good news thankfully 🪿
October 15, 2025 at 11:26 AM
So I've had to stop training altogether due to fatigue which is difficult tbh however the retatrutide does seem to be working as my love handles have shrank quite significantly and I only had my first jab on Saturday so that's good news thankfully 🪿
#GLP1 medicines now address weight loss and other health conditions through innovative formulations and expanded indications, highlighting key questions about their efficacy and safety.
ja.ma/4og9wNX
ja.ma/4og9wNX
October 14, 2025 at 4:00 PM
#GLP1 medicines now address weight loss and other health conditions through innovative formulations and expanded indications, highlighting key questions about their efficacy and safety.
ja.ma/4og9wNX
ja.ma/4og9wNX
My new 500 vial freezer storage box is amazing. #peptides #glp #retatrutide #biohacking #glp1 #peptide
October 12, 2025 at 2:03 AM
My new 500 vial freezer storage box is amazing. #peptides #glp #retatrutide #biohacking #glp1 #peptide
I'm guessing that this will apply to Retatrutide as well, since it's a GIP agonist, right?
September 29, 2025 at 4:46 PM
I'm guessing that this will apply to Retatrutide as well, since it's a GIP agonist, right?
2 years ago today I took the first dose of what ended up being retatrutide. 21 tubes of blood. One injection in front of the lead investigator. I was the 498th patient (out of 2300) to get Reta. My life has wildly changed for the positive because of it. Can't wait for the trial data on spring 2026!
September 25, 2025 at 3:05 PM
2 years ago today I took the first dose of what ended up being retatrutide. 21 tubes of blood. One injection in front of the lead investigator. I was the 498th patient (out of 2300) to get Reta. My life has wildly changed for the positive because of it. Can't wait for the trial data on spring 2026!
As I've upped GLP-1 Retatrutide dose: I find social media diminishing in interest as to your opinions, or anyone knowing mine. I'm close to quitting alcohol. I thought I was cheating on my diet but still lost weight the fastest I'd ever seen. This did not happen on even high-dose Tirzepatide.
September 16, 2025 at 7:42 PM
As I've upped GLP-1 Retatrutide dose: I find social media diminishing in interest as to your opinions, or anyone knowing mine. I'm close to quitting alcohol. I thought I was cheating on my diet but still lost weight the fastest I'd ever seen. This did not happen on even high-dose Tirzepatide.
Even in the shorter term phase 2 data the average triglyceride reduction was 40% on retatrutide. Lilly did a deeper dive on that data and found retatrutide down regulates ApoC3 and ANGPTL3/8 both of which are critical factors for triglyceride levels.
September 16, 2025 at 6:12 PM
Even in the shorter term phase 2 data the average triglyceride reduction was 40% on retatrutide. Lilly did a deeper dive on that data and found retatrutide down regulates ApoC3 and ANGPTL3/8 both of which are critical factors for triglyceride levels.
4 month update on my sister's retatrutide trial:
She's down 30lbs now! Nearly 2lbs a week for 16 weeks straight.
Triglycerides down 63%
Total cholesterol down 21%
LDL down 14%
VLDL down 38%
GFR is up ~9%
Endometriosis symptoms have significantly decreased.
Just amazing drug as always.
She's down 30lbs now! Nearly 2lbs a week for 16 weeks straight.
Triglycerides down 63%
Total cholesterol down 21%
LDL down 14%
VLDL down 38%
GFR is up ~9%
Endometriosis symptoms have significantly decreased.
Just amazing drug as always.
September 16, 2025 at 12:57 AM
4 month update on my sister's retatrutide trial:
She's down 30lbs now! Nearly 2lbs a week for 16 weeks straight.
Triglycerides down 63%
Total cholesterol down 21%
LDL down 14%
VLDL down 38%
GFR is up ~9%
Endometriosis symptoms have significantly decreased.
Just amazing drug as always.
She's down 30lbs now! Nearly 2lbs a week for 16 weeks straight.
Triglycerides down 63%
Total cholesterol down 21%
LDL down 14%
VLDL down 38%
GFR is up ~9%
Endometriosis symptoms have significantly decreased.
Just amazing drug as always.
Hard to say, but it's a possibility. Obviously we have essentially no data on switching from tirzepatide to retatrutide for diabetes but the extra mechanism of action could get you under 5 especially because it increases insulin sensitivity so much.
March 17, 2025 at 10:00 AM
Hard to say, but it's a possibility. Obviously we have essentially no data on switching from tirzepatide to retatrutide for diabetes but the extra mechanism of action could get you under 5 especially because it increases insulin sensitivity so much.