Weekly CTU Trial Update! 📢
Huge milestones this week:
@easyas-trial.bsky.social welcomed its 1,000th UK participant and completed an SIV with Erasmus MC, Netherlands!
Momentum continues for @coloprevent.bsky.social with a new Resveratrol trial randomisation. Onwards! 📈
Huge milestones this week:
@easyas-trial.bsky.social welcomed its 1,000th UK participant and completed an SIV with Erasmus MC, Netherlands!
Momentum continues for @coloprevent.bsky.social with a new Resveratrol trial randomisation. Onwards! 📈
November 10, 2025 at 8:40 AM
Weekly CTU Trial Update! 📢
Huge milestones this week:
@easyas-trial.bsky.social welcomed its 1,000th UK participant and completed an SIV with Erasmus MC, Netherlands!
Momentum continues for @coloprevent.bsky.social with a new Resveratrol trial randomisation. Onwards! 📈
Huge milestones this week:
@easyas-trial.bsky.social welcomed its 1,000th UK participant and completed an SIV with Erasmus MC, Netherlands!
Momentum continues for @coloprevent.bsky.social with a new Resveratrol trial randomisation. Onwards! 📈
In my experience, this is generally only a significant problem when there's a lot of what we used to call "points of contact" involving randomisation.
If it's the kind of play where a GM is asking for skill checks every 20 seconds then you're going to get bogged down in card logistics.
If it's the kind of play where a GM is asking for skill checks every 20 seconds then you're going to get bogged down in card logistics.
November 9, 2025 at 10:29 AM
In my experience, this is generally only a significant problem when there's a lot of what we used to call "points of contact" involving randomisation.
If it's the kind of play where a GM is asking for skill checks every 20 seconds then you're going to get bogged down in card logistics.
If it's the kind of play where a GM is asking for skill checks every 20 seconds then you're going to get bogged down in card logistics.
New blog post: The population model and the randomisation model of statistical inference
janhove.github.io/posts/2025-1...
janhove.github.io/posts/2025-1...
November 9, 2025 at 9:37 AM
New blog post: The population model and the randomisation model of statistical inference
janhove.github.io/posts/2025-1...
janhove.github.io/posts/2025-1...
aleatory.
A term used to describe art where there is a chance element in it, where a degree of randomisation is brought in. There is no need to wait for the artist to do this: simply take any painting or book, cut it into small pieces, and even the most mundane art can become vibrant and new.
A term used to describe art where there is a chance element in it, where a degree of randomisation is brought in. There is no need to wait for the artist to do this: simply take any painting or book, cut it into small pieces, and even the most mundane art can become vibrant and new.
November 8, 2025 at 9:52 PM
aleatory.
A term used to describe art where there is a chance element in it, where a degree of randomisation is brought in. There is no need to wait for the artist to do this: simply take any painting or book, cut it into small pieces, and even the most mundane art can become vibrant and new.
A term used to describe art where there is a chance element in it, where a degree of randomisation is brought in. There is no need to wait for the artist to do this: simply take any painting or book, cut it into small pieces, and even the most mundane art can become vibrant and new.
In awe of the perfection of scattered colours, sizes and shapes. Perfect randomisation.
November 8, 2025 at 12:01 PM
In awe of the perfection of scattered colours, sizes and shapes. Perfect randomisation.
The product of randomisation in music .... Stoned Jazz
#Jazz #Music #Bandcamp
academy-of-rock.bandcamp.com/track/stoned...
#Jazz #Music #Bandcamp
academy-of-rock.bandcamp.com/track/stoned...
Stoned Jazz, by Ignorance is Bliss
from the album Jazz Club
academy-of-rock.bandcamp.com
November 8, 2025 at 10:55 AM
The product of randomisation in music .... Stoned Jazz
#Jazz #Music #Bandcamp
academy-of-rock.bandcamp.com/track/stoned...
#Jazz #Music #Bandcamp
academy-of-rock.bandcamp.com/track/stoned...
It’s just drawing the line 3 times with offsets & a bit of randomisation, then varying line width based on speed
November 7, 2025 at 2:31 PM
It’s just drawing the line 3 times with offsets & a bit of randomisation, then varying line width based on speed
I understand Mendelian randomisation as a form of instrumental variables.
And like all instrumental variables, it's black magic and not to be trusted.
And like all instrumental variables, it's black magic and not to be trusted.
November 6, 2025 at 7:51 PM
I understand Mendelian randomisation as a form of instrumental variables.
And like all instrumental variables, it's black magic and not to be trusted.
And like all instrumental variables, it's black magic and not to be trusted.
Yeah, more examples and better randomisation would have been more satisfying (and probably more useful, tbh)
November 4, 2025 at 3:39 PM
Yeah, more examples and better randomisation would have been more satisfying (and probably more useful, tbh)
So in a way seeing trains in operation feels like observing one large mechanism/contraption (like a mechanical cuckoo clock or astrological one) with some level of predictability, marvelling at complexity and automation of it's parts, while it still has enough randomisation to keep it fresh.
November 4, 2025 at 11:51 AM
So in a way seeing trains in operation feels like observing one large mechanism/contraption (like a mechanical cuckoo clock or astrological one) with some level of predictability, marvelling at complexity and automation of it's parts, while it still has enough randomisation to keep it fresh.
Congratulations to PI Graeme Ambler & the Research Delivery Team at Cambridge University Hospitals NHS Foundation Trust for randomising the 2️⃣nd participant in November!🎇🎇 Cambridge have been open for 1️⃣6️⃣ months & with 2️⃣8️⃣ participants have an above average monthly randomisation rate of 1️⃣.7️⃣5️⃣ per month!
November 4, 2025 at 10:36 AM
Congratulations to PI Graeme Ambler & the Research Delivery Team at Cambridge University Hospitals NHS Foundation Trust for randomising the 2️⃣nd participant in November!🎇🎇 Cambridge have been open for 1️⃣6️⃣ months & with 2️⃣8️⃣ participants have an above average monthly randomisation rate of 1️⃣.7️⃣5️⃣ per month!
Last I went they gave you an hour free. Turning on non-persistent MAC randomisation meant you could get another free hour by disconnecting and reconnecting. And I swear the walls are a cage to prevent you using your own data...
November 3, 2025 at 9:04 PM
Last I went they gave you an hour free. Turning on non-persistent MAC randomisation meant you could get another free hour by disconnecting and reconnecting. And I swear the walls are a cage to prevent you using your own data...
“Intercurrent events” are post-randomisation events (eg discontinuation of treatment or treatment switching) and the estimand describes precisely how these events will be handled in the analysis. 3/8
November 3, 2025 at 7:44 AM
“Intercurrent events” are post-randomisation events (eg discontinuation of treatment or treatment switching) and the estimand describes precisely how these events will be handled in the analysis. 3/8
#BabyPferd couldn't decide which game to play, so I modified a simple randomisation code to decide for us. It chose "Tricky Wave", which made her realise she'd like to play Snap. Which basically made me feeling exactly how a field partner deciding they won't randomise my study, after all, does.
November 2, 2025 at 9:08 PM
#BabyPferd couldn't decide which game to play, so I modified a simple randomisation code to decide for us. It chose "Tricky Wave", which made her realise she'd like to play Snap. Which basically made me feeling exactly how a field partner deciding they won't randomise my study, after all, does.
New Mendelian randomisation study finds no strong evidence that higher genetically predicted adiposity increases head & neck cancer risk. This suggests obesity itself may not be a major causal driver, after accounting for smoking.
buff.ly/G0cu6i0
buff.ly/G0cu6i0
November 1, 2025 at 2:59 PM
New Mendelian randomisation study finds no strong evidence that higher genetically predicted adiposity increases head & neck cancer risk. This suggests obesity itself may not be a major causal driver, after accounting for smoking.
buff.ly/G0cu6i0
buff.ly/G0cu6i0
🏆 We need 3 more randomisations to secure the all-time monthly record. Which site/team will secure the final randomisation? Two days left to claim the victory! Tag your colleagues! @nihr.bsky.social @mft-edi.bsky.social @nhsuhlg-ri.bsky.social @nhsuhlg.bsky.social
October 30, 2025 at 8:13 AM
🏆 We need 3 more randomisations to secure the all-time monthly record. Which site/team will secure the final randomisation? Two days left to claim the victory! Tag your colleagues! @nihr.bsky.social @mft-edi.bsky.social @nhsuhlg-ri.bsky.social @nhsuhlg.bsky.social
Path to Nowhere CN Look-Ahead (October 2025)
01. Optimising In-Battle UI/VFX Obstruction
02. Record Player Optimisation
03. New Sinner Tag Filter
04. Carousel Theme/Sinner/Scene Randomisation Support
01. Optimising In-Battle UI/VFX Obstruction
02. Record Player Optimisation
03. New Sinner Tag Filter
04. Carousel Theme/Sinner/Scene Randomisation Support
October 29, 2025 at 4:16 PM
Path to Nowhere CN Look-Ahead (October 2025)
01. Optimising In-Battle UI/VFX Obstruction
02. Record Player Optimisation
03. New Sinner Tag Filter
04. Carousel Theme/Sinner/Scene Randomisation Support
01. Optimising In-Battle UI/VFX Obstruction
02. Record Player Optimisation
03. New Sinner Tag Filter
04. Carousel Theme/Sinner/Scene Randomisation Support
No evidence for a causal link between plasma lipids and multiple sclerosis susceptibility and severity: a Mendelian randomisation study #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.27.25338893v1
http://medrxiv.org/cgi/content/short/2025.10.27.25338893v1
October 29, 2025 at 8:02 AM
No evidence for a causal link between plasma lipids and multiple sclerosis susceptibility and severity: a Mendelian randomisation study #NeuroDegeneration 🧪🧠
http://medrxiv.org/cgi/content/short/2025.10.27.25338893v1
http://medrxiv.org/cgi/content/short/2025.10.27.25338893v1
No evidence for a causal link between plasma lipids and multiple sclerosis susceptibility and severity: a Mendelian randomisation study https://www.medrxiv.org/content/10.1101/2025.10.27.25338893v1
October 29, 2025 at 12:26 AM
No evidence for a causal link between plasma lipids and multiple sclerosis susceptibility and severity: a Mendelian randomisation study https://www.medrxiv.org/content/10.1101/2025.10.27.25338893v1
Ophthopedia Update: No evidence of a causal relationship between negative emotions and glaucoma: evidence triangulation from genetic correlation, Mendelian randomisation and colocalisation: Purpose
Observational studies suggest that anxiety and depression disorders have significant correlation,…
Observational studies suggest that anxiety and depression disorders have significant correlation,…
No evidence of a causal relationship between negative emotions and glaucoma: evidence triangulation from genetic correlation, Mendelian randomisation and colocalisation
Purpose
Observational studies suggest that anxiety and depression disorders have significant correlation, but these results may have been influenced by confounding factors, and negative emotions that do not meet the criteria for clinical mental disease diagnosis are more common, the evidence for this association is unclear. This study employed whole-genome linkage disequilibrium score regression (LDSC), Mendelian randomisation (MR), Bayesian colocalisation (colocalisation) to explore association between common negative emotions and glaucoma.
Design
Bidirectional genetic associations between negative emotion and glaucoma.
Participants
Data from UK Biobank and FinnGen R10.
Methods
MR, whole-genome LDSC, Bayesian colocalisation.
Main outcome measures
Genetic causal associations between negative emotion and glaucoma.
Result
At Bonferroni-corrected levels of significance, there was no genetic correlation, causal association or shared genetic mechanism between any negative emotions and glaucoma, except for depression, which showed a genetic link but no causal evidence.
Conclusions
Depression, anxiety and eight other common negative emotions may not be causally associated with glaucoma and there may be no genetic correlation between them.
dlvr.it
October 28, 2025 at 12:14 PM
Ophthopedia Update: No evidence of a causal relationship between negative emotions and glaucoma: evidence triangulation from genetic correlation, Mendelian randomisation and colocalisation: Purpose
Observational studies suggest that anxiety and depression disorders have significant correlation,…
Observational studies suggest that anxiety and depression disorders have significant correlation,…
I do not think I will ever fully understand Medelian Randomisation
October 28, 2025 at 10:10 AM
I do not think I will ever fully understand Medelian Randomisation
I love @kholbatar.bsky.social art, so wanted to continue the flow of reposting, even though what I create is... I'll say "unskilled" in comparison 😂
I have my moments.
Reskeet with yours.
I have my moments.
Reskeet with yours.
October 27, 2025 at 4:02 PM
I love @kholbatar.bsky.social art, so wanted to continue the flow of reposting, even though what I create is... I'll say "unskilled" in comparison 😂
I have my moments.
Reskeet with yours.
I have my moments.
Reskeet with yours.
Please follow me there for more Lockwoods, as I work to transition from the Sims 4 to an entirely new world. As I said before I am going to continue the main arc here, as Sims Lit, but I will step away from the game entirely. What I need to do is plan out some randomisation.
#TheLockwoods
#TheLockwoods
October 27, 2025 at 11:29 AM
Please follow me there for more Lockwoods, as I work to transition from the Sims 4 to an entirely new world. As I said before I am going to continue the main arc here, as Sims Lit, but I will step away from the game entirely. What I need to do is plan out some randomisation.
#TheLockwoods
#TheLockwoods
A key reason for extending the 3 year BA partial randomisation pilot for small grants for a further 3 years is to generate more evidence re any impact of partial randomisation on outputs (and thus to get at your more/less 'effective' point). A RCT would be a fine thing, but tricky to orchestrate.
October 25, 2025 at 10:16 AM
A key reason for extending the 3 year BA partial randomisation pilot for small grants for a further 3 years is to generate more evidence re any impact of partial randomisation on outputs (and thus to get at your more/less 'effective' point). A RCT would be a fine thing, but tricky to orchestrate.
We’ve been using partial randomisation for over 3 years for our small research grants and it’s reduced bureaucracy, improved diversity (including institutionally) and those who fail the lottery can still tell promotion cttes if they hit our quality bar
www.timeshighereducation.com/news/grants-...
www.timeshighereducation.com/news/grants-...
Grants awarded by lottery popular with minority, junior scholars
Unexpected upsides of ‘randomised’ funding include greater acceptance among rejected applicants, says British Academy head
www.timeshighereducation.com
October 25, 2025 at 10:05 AM
We’ve been using partial randomisation for over 3 years for our small research grants and it’s reduced bureaucracy, improved diversity (including institutionally) and those who fail the lottery can still tell promotion cttes if they hit our quality bar
www.timeshighereducation.com/news/grants-...
www.timeshighereducation.com/news/grants-...