Love this exquisite spatiotemporal study on the construction of cortical perivascular niche🤩

Vessel coverage: #SmoothMuscleCell & Astrocyte earlier than #PerivascularMacrophages & #PerivascularFibroblast

Dysplastic cerebrovasculature in human #ArterioVenousMalformation

Vessel-enriched scRNAseq

Up to 8 #SmoothMuscleCell subclusters

2 MYOCD-LGALS3+ #Fibromyocyte subset😆
▶️A transition population b/w SMC & #PerivascularFibroblast?

#Science 2022
www.science.org/doi/10.1126/...

Meningeal Origin+Migration/Proliferation dynamics of #PerivascularFibroblast in postnatal (P5-14)🐭🧠vasculature

PF undergoes clonal expansion on penetrating vessels😆

Julie Siegenthaler lab Development 2023
journals.biologists.com/dev/article/...