#PRTC
2/2 Similar oral↔gut strains expand in gut; translocators carry collagenase-like prtC gene (fecal prtC abundance being a robust ACLD biomarker - auPR 0.91); prtC⁺ isolates worsen barrier & fibrosis in CCl₄ mice; collagenase activity increases in patients; prtC activity was confirmed for V. parvula.
October 20, 2025 at 11:43 AM
🚨 New preprint 🚨

In cirrhosis, oral👄 microbes (Veillonella, Streptococcus) translocate ↘️ gut, carry a collagenase-like enzyme (prtC), disrupt⛓️‍💥 the intestinal barrier & ⬆️ hepatic fibrosis 🧬

www.biorxiv.org/content/10.1...
Microbial oral-gut translocation in advanced chronic liver disease is linked to exacerbation of intestinal barrier dysfunction and hepatic fibrosis
While microbiome perturbations are associated with advanced chronic liver disease (ACLD), microbial disease mechanisms are poorly understood. Using multi-omics analyses of paired saliva and faecal sam...
www.biorxiv.org
September 28, 2025 at 8:06 AM
Shuttle Bus Locations:

Vienna Station:
Bus Bay M (MetroAccess) -
stop ID #5004711

Dunn Loring Station:
Bus Bay E - stop ID #5004799

West Falls Church Station:
Bus Bay G- (PRTC) - stop ID #5001955

Customers can board F50 from Vienna to Ballston Station.
September 13, 2025 at 9:47 AM
Laljit Bhullar meets Transport Unions; assures Swift Resolution of Genuine Demands

Punjab Newsline, Chandigarh- Punjab Transport Minister Laljit Singh Bhullar held a detailed meeting with the representatives of the Punjab Roadways/PUNBUS/PRTC Contract Workers Union and the Punjab Roadways (PUNBUS)…
Laljit Bhullar meets Transport Unions; assures Swift Resolution of Genuine Demands
Punjab Newsline, Chandigarh- Punjab Transport Minister Laljit Singh Bhullar held a detailed meeting with the representatives of the Punjab Roadways/PUNBUS/PRTC Contract Workers Union and the Punjab Roadways (PUNBUS) State Transport Workers Union to deliberate on their demands. The meeting was attended by the Union leaders including State President Resham Singh Gill, State General Secretaryr. Shamsher Singh Dhillon, Senior Vice President Jaspal Singh Bajwa among others. The Transport Minister was accompanied by Secretary Transport Varun Roojam, Managing Director PRTC BS Shergill, Director State Transport Rajeev Kumar Gupta along with senior officials of the Finance and Personnel Departments.
balkikhalnews.com
August 19, 2025 at 11:45 AM
Over 3,000 state buses to remain off road today

Nearly 3,000 buses of the state public sector undertakings — PRTC, Punbus and Punjab Roadways — will remain off road tomorrow, as the employees’ unions of the undertakings have gone on strike.Meanwhile, commuters are set to face a lot of…
Over 3,000 state buses to remain off road today
Nearly 3,000 buses of the state public sector undertakings — PRTC, Punbus and Punjab Roadways — will remain off road tomorrow, as the employees’ unions of the undertakings have gone on strike.Meanwhile, commuters are set to face a lot of inconvenience as the government has failed to make any alternative arrangement for them.After a failed dialogue with the state government over floating tenders for issuing bus permits under the kilometre scheme to private players, the unions today announced that the strike would continue till their demands were met.Harkesh Kumar, senior vice-president of the PRTC, Punbus and Punjab Roadways contract workers unions, said apart from scrapping the tenders under the kilometre scheme for private players, the unions had alleged that the Transport Minister Laljit Bhullar had failed to fulfil their demands.The government has called for another round of meeting with the union leader tomorrow to end the dialogue.
balkikhalnews.com
August 15, 2025 at 8:43 PM
PRTC strike disrupts travel across Punjab as 8,000 contractual workers protest

Commuters across the state faced significant travel disruptions as approximately 8,000 contractual employees of the Pepsu Road Transport Corporation (PRTC) and Punbus staged a strike across 27 depots in Punjab. The…
PRTC strike disrupts travel across Punjab as 8,000 contractual workers protest
Commuters across the state faced significant travel disruptions as approximately 8,000 contractual employees of the Pepsu Road Transport Corporation (PRTC) and Punbus staged a strike across 27 depots in Punjab. The protest resulted in a halt of government-run buses, leaving many passengers stranded and chasing private buses in the rain to reach their destinations. At the new interstate bus terminus, Harkesh Vicky, vice president of the PRTC Contractual Employees Union, expressed frustration over the lack of action from the government. Despite 45 meetings with Chief Minister Bhagwant Singh Mann, finance minister Harpal Singh Cheema and transport minister Laljit Singh Bhullar, he claimed that their demands, including job regularisation and pay parity, remain unaddressed.
balkikhalnews.com
August 15, 2025 at 12:39 PM
$PRTC -1% [Vedanta's VE202 failed its Phase 2 UC study, missing its primary endpoint, though well-tolerated. The company will now focus on VE303 (C. difficile Phase 3) and VE707.] news.puretechhealth.com/news-release...
August 13, 2025 at 4:30 PM
#PRTC PureTech Founded Entity Vedanta Biosciences Announces Phase 2 Study of VE202 in Ulcerative Colitis Did Not Meet Primary Endpoint

https://www.stocktitan.net/news/PRTC/pure-tech-founded-entity-vedanta-biosciences-announces-phase-2-study-hgkgis1qkjql.html
PureTech Founded Entity Vedanta Biosciences Announces Phase 2 Study of VE202 in Ulcerative Colitis Did Not Meet Primary Endpoint
Vedanta Biosciences, a PureTech (NASDAQ: PRTC) Founded Entity, announced that its Phase 2 COLLECTiVE202 study of VE202 for ulcerative colitis (UC) treatment failed to meet its primary endpoint of endoscopic response. While the treatment was well-tolerated with no serious adverse events, the response rates were not statistically different from placebo.The company will now focus on its lead program VE303, currently in Phase 3 trials for recurrent Clostridioides difficile infection (CDI). VE303 previously showed promising Phase 2 results with a 30.5% absolute risk reduction compared to placebo. The program has received Fast Track and Orphan Drug designations from the FDA. Additionally, Vedanta is advancing VE707 for preventing multidrug-resistant infections, with an IND submission planned for 2026.
www.stocktitan.net
August 13, 2025 at 4:16 PM
PureTech spins out new lung disease unit to advance IPF candidate $PRTC firstwordpharma.com/story/5988322
August 12, 2025 at 3:13 PM
Potomac & Rappahannock Transportation Commission (PRTC) successfully modernized their CAD/AVL system by migrating to the Vontas Cloud. The result? A smooth six-month implementation that marked a major step forward in transit innovation. Read the full story: vontas.com/how-prtc-sec...
June 26, 2025 at 2:47 PM
#PRTC #VOR PureTech Founded Entity Vor Bio Announces Exclusive Global License Agreement with RemeGen for Late-Stage Autoimmune Asset and $175 Million Private Placement

https://www.stocktitan.net/news/PRTC/pure-tech-founded-entity-vor-bio-announces-exclusive-global-license-00phr8ffq4rm.html
PureTech Founded Entity Vor Bio Announces Exclusive Global License Agreement with RemeGen for Late-Stage Autoimmune Asset and $175 Million Private Placement
PureTech's (Nasdaq: PRTC) Founded Entity Vor Bio (Nasdaq: VOR) has secured an exclusive global license agreement with RemeGen for telitacicept, a novel dual-target fusion protein, along with a $175 million private placement. The license agreement grants Vor Bio rights outside Greater China and includes an initial payment of $125 million ($45M upfront + $80M in warrants), with potential regulatory and commercial milestones exceeding $4 billion plus tiered royalties.Telitacicept, already approved in China for multiple autoimmune conditions, is currently in global Phase 3 trials with results expected in H1 2027. Additionally, Vor Bio appointed Dr. Jean-Paul Kress as CEO and Chairman, replacing Dr. Robert Ang.The private placement involves issuing warrants for 700 million shares at $0.25 per warrant, closing expected on June 27, 2025.
www.stocktitan.net
June 26, 2025 at 6:00 AM
ついに初上陸!「台湾祭 in 奈良橿原2025」開催決定!台湾の風を感じる、旅気分を奈良で。 www.nara-np.co.jp/prtimes/prtc...
ついに初上陸!「台湾祭 in 奈良橿原2025」開催決定!台湾の風を感じる、旅気分を奈良で。|奈良新聞デジタル
www.nara-np.co.jp
June 2, 2025 at 4:21 AM
#PRTC PureTech’s Deupirfenidone (LYT-100) Demonstrates Strong and Durable Efficacy as a Monotherapy with Favorable Tolerability in Phase 2b ELEVATE IPF Trial

https://www.stocktitan.net/news/PRTC/pure-tech-s-deupirfenidone-lyt-100-demonstrates-strong-and-durable-w8agbq2zyov7.html
PureTech’s Deupirfenidone (LYT-100) Demonstrates Strong and Durable Efficacy as a Monotherapy with Favorable Tolerability in Phase 2b ELEVATE IPF Trial
PureTech Health (PRTC) presented promising Phase 2b ELEVATE IPF trial results for deupirfenidone (LYT-100) at the 2025 ATS Conference. The drug demonstrated significant efficacy in treating idiopathic pulmonary fibrosis (IPF). At 825 mg TID dosing, deupirfenidone showed an 80.9% treatment effect vs. placebo, approximately 50% greater than pirfenidone's 54.1% effect. The drug slowed lung function decline to -21.5 mL over 26 weeks and preliminary 52-week data showed -32.8 mL decline, comparable to healthy older adults' natural decline. Importantly, deupirfenidone maintained favorable tolerability despite 50% higher drug exposure compared to pirfenidone. PureTech plans to meet with the FDA by Q3 2025 and aims to initiate Phase 3 trials by year-end.
www.stocktitan.net
May 20, 2025 at 9:15 PM
INDIA: PRTC workers renew protest against Punjab govt over long-pending demands yespunjab.com/prtc-workers...
PRTC workers renew protest against Punjab govt over long-pending demands - Yes Punjab News
PRTC workers protest in Barnala over unmet demands, including salary delays and reinstatement, threatening a statewide agitation if not addressed soon.
yespunjab.com
May 18, 2025 at 11:02 AM
#PRTC PureTech Announces Publication of New Research Highlighting Untold Experiences of People Living with Idiopathic Pulmonary Fibrosis (IPF)

https://www.stocktitan.net/news/PRTC/pure-tech-announces-publication-of-new-research-highlighting-untold-a1r96o5g21q5.html
PureTech Announces Publication of New Research Highlighting Untold Experiences of People Living with Idiopathic Pulmonary Fibrosis (IPF)
PureTech Health (NASDAQ: PRTC) has published new research in BMC Pulmonary Medicine revealing critical insights into the experiences of people living with Idiopathic Pulmonary Fibrosis (IPF). The study, conducted with 106 IPF patients across the US, highlighted significant challenges in diagnosis, treatment, and quality of life.Key findings include varied diagnosis timelines with frequent delays, low antifibrotic treatment uptake, and challenges in managing multiple health conditions. Nearly 90% of participants reported managing additional health challenges alongside IPF. The research also revealed that while supplemental oxygen therapy provides symptom relief, patients face logistical, financial, and emotional challenges.The study, led by Dr. Camilla Graham and conducted in collaboration with experts from the University of Alabama, Vanderbilt University Medical Center, and the Pulmonary Fibrosis Foundation, emphasizes the need for enhanced disease awareness, streamlined diagnosis, and patient-centered treatment approaches.
www.stocktitan.net
May 9, 2025 at 11:00 AM
PureTech ($PRTC) reports solid FY results! Revenue soared 45% Y/Y to $4.83M, and GAAP EPS came in at $0.21. 💪 Positive signs! #Earnings #Stocks #Biotech
April 30, 2025 at 9:00 AM
Cheema Holds Meeting with Roadways Punbus/PRTC Contract Workers Union

Assures early resolution of legitimate demands Punjab Newsline, Chandigarh, April 9- Punjab Finance Minister Harpal Singh Cheema held a meeting with the Punjab Roadways Punbus/PRTC Contract Workers Union on Wednesday to address…
Cheema Holds Meeting with Roadways Punbus/PRTC Contract Workers Union
Assures early resolution of legitimate demands Punjab Newsline, Chandigarh, April 9- Punjab Finance Minister Harpal Singh Cheema held a meeting with the Punjab Roadways Punbus/PRTC Contract Workers Union on Wednesday to address their demands comprehensively. The meeting took place at his office in the Punjab Secretariat and was attended by Transport Minister Laljit Singh Bhullar and ACS (Transport) D.K. Tiwari. During the discussions, Cheema reaffirmed the Punjab government's commitment to the welfare of its employees under the leadership of Chief Minister Bhagwant Singh Mann. He said that the Cabinet Sub-Committee, which he chairs, has implemented a policy aimed at regularizing the services of numerous contract-based employees without subjecting them to legal hurdles.
balkikhalnews.com
April 10, 2025 at 4:57 AM