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fmartin54.bsky.social
Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

journals.plos.org/plosbiology/...
Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates
Fungi in the gut microbiome (the "mycobiome") are a neglected component of the human holobiont. This study of gut fungal profiles across natural populations of humans and non-human primates reveals si...
journals.plos.org
November 12, 2025 at 7:16 AM
roederlab.bsky.social
journals.plos.org/plosbiology/...
A common pathway controls cell size in the sepal and leaf epidermis leading to a nonrandom pattern of giant cells
Arabidopsis leaf epidermal cells have a wide range of sizes and ploidies, but the mechanisms patterning their size and spatial distribution remain unclear. This study shows that the pathway controllin...
journals.plos.org
November 11, 2025 at 8:31 PM
richardsever.bsky.social
And another thing: I am far more concerned with data provenance and information/identity verification than peer review right now… 1/2 journals.plos.org/plosbiology/...
November 7, 2025 at 2:30 PM
tomrhysmarshall.bsky.social
I like this recent one on heart-brain interactions.

The phase of the cardiac cycle modulates the excitability of the motor cortex.

journals.plos.org/plosbiology/...
Cardiac activity impacts cortical motor excitability
Human cognition and action can be influenced by internal bodily processes such as heartbeats. By studying motor excitability and muscle activity across the cardiac cycle of humans, this study reveals ...
journals.plos.org
November 7, 2025 at 8:38 AM
jeffspence.github.io
Using theory developed by @yuvalsim.bsky.social and @gs2747.bsky.social (journals.plos.org/plosbiology/...) we predicted that burden tests rank genes by SPECIFICITY!

This is surprising! Burden tests DO NOT rank genes by IMPORTANCE!

These predictions play out in the UKB.

8/n
Left side shows a cartoon of the derivation for why burden test rank genes in part by trait specificity. Selection decreases LoF frequencies, with frequency being inversely proportional to the selection coefficient. Selection is driven by importance across all traits, with the selection coefficient being proportional to the sum of squared effects on all traits. The right hand side shows a stratified QQ plot, where more specifically-expressed genes tend to have much stronger burden test signals.
November 7, 2025 at 12:05 AM
zebrafishrock.bsky.social
Working link: journals.plos.org/plosbiology/...
plosbiology.org PLOS Biology @plosbiology.org · 5d
Mammalian #muscle fiber contractions require voltage-gated #SodiumChannels. This study shows that #zebrafish fast muscle fibers don't require Nav channels, suggesting how anatomical & physiological differences from mouse muscles ensure efficient contraction @plosbiology.org 🧪https://plos.io/49BMaOD
AChRs and nuclei labeling with α-bungarotoxin (red) and Hoechst (blue), respectively, in fast muscle fibers from control (CT, top) and mutant fish (DM, bottom). Measurements were made on Z-stacks images of whole fibers by dividing each fiber at its equator and applying Z-projection to each half. Z-projections of the upper half of a representative CT and DM fiber are shown (upper panels). Euclidean distance transformation of half-fiber Z-projection generated a distance mapping visualized by colored gradient (lower panels). Bar = 30 µm.
November 6, 2025 at 5:57 PM
graham-raby.bsky.social
Special thanks to @dianasmadeira.bsky.social for authoring this thoughtful primer about the study we published this week in @plosbiology.org Good suggestions about all the work we still need to do to unveil the mechanisms underlying variation in thermal tolerance.

journals.plos.org/plosbiology/...
November 5, 2025 at 11:53 PM
avsp.bsky.social
When brain talks back to the eye "The state of our brain shapes what we see, but how early in the visual system does this start? A new study in PLOS Biology shows that brain state-dependent release of histamine modulates the very first stage of vision in the retina" journals.plos.org/plosbiology/...
When the brain talks back to the eye
The state of our brain shapes what we see, but how early in the visual system does this start? This Primer explores a new PLOS Biology study which shows that brain state-dependent release of histamine...
journals.plos.org
November 5, 2025 at 9:30 PM
erlangen.bsky.social
Noise pollution is linked to devastating neurological diseases
journals.plos.org/plosbiology/...
www.dailymail.co.uk/health/artic...
Lärmbelastung ruiniert die Gesundheit:
Schluß mit dem Böllerterror zu Silvester❗ 3.1.2025
5 Tote durch Böller in, Tausende schwere Verletzungen
taz.de/Debatte-uebe...
Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson’s Disease
Prolonged exposure to environmental noise has been associated with the occurrence neurodegenerative diseases. This study demonstrates that environmental noise promotes the onset of Parkinson's disease...
journals.plos.org
November 5, 2025 at 5:34 PM
zebrafishrock.bsky.social
🔗 to paper: journals.plos.org/plosbiology/...
November 5, 2025 at 10:41 AM
jutfelt.bsky.social
@rachaelmorgan.bsky.social @leon-at-sea.bsky.social

Link to the open access paper:
journals.plos.org/plosbiology/...
Oxygen supersaturation has negligible effects on warming tolerance across diverse aquatic ectotherms
Oxygen supersaturation in aquatic ecosystems has been proposed to buffer against heat stress in water-breathing animals. This study re-examines this question in a diverse panel of aquatic ectotherms, ...
journals.plos.org
November 5, 2025 at 10:34 AM
reproducibilitea.org
📚 High prevalence of articles with image-related problems in animal studies of subarachnoid hemorrhage and low rates of correction by publishers
journals.plos.org/plosbiology/...
High prevalence of articles with image-related problems in animal studies of subarachnoid hemorrhage and low rates of correction by publishers
Unchallenged erroneous articles can undermine scientific progress and mislead future research. This study shows that image-related issues affect 40% of reviewed articles on early brain injury in anima...
journals.plos.org
November 4, 2025 at 1:57 PM
keholsinger.bsky.social
It's surprising that this is even a question, but was anyone asked about "de-extincting" the dire wolf? - Should scientists be allowed to bring distant human ancestors back to life? journals.plos.org/plosbiology/...
Should scientists be allowed to bring distant human ancestors back to life?
Recently, several attempts have been made to modify modern species with ancient DNA in the name of ‘de-extinction’. This Perspective argues that independent ethical oversight needs to be put in place…
journals.plos.org
November 4, 2025 at 1:38 PM
cbuunito.bsky.social
journals.plos.org/plosbiology/...
Simple scaling laws control the genetic architectures of human complex traits
Genome-wide association studies have revealed that the genetic architectures of complex traits vary widely. This study shows that differences in architectures of highly polygenic traits arise mainly f...
journals.plos.org
November 4, 2025 at 1:34 PM
jeromeollier.bsky.social
eDNA surveys substantially expand known geographic and ecological niche boundaries of marine fishes - @plosbiology.org

journals.plos.org/plosbiology/...
eDNA surveys substantially expand known geographic and ecological niche boundaries of marine fishes
Global species records often underestimate marine fish distributions due to sampling biases, especially in remote regions. This study shows that environmental DNA surveys significantly expand known ge...
journals.plos.org
November 3, 2025 at 11:55 PM
richardsever.bsky.social
THIS. In all the discussions about Publish-Review-Curate, alt peer review models, etc., too often the other things (good) journals (should) do are often omitted. Information verification and many other checks are as, if not more important, journals.plos.org/plosbiology/...
November 3, 2025 at 2:26 PM
ertrunnell.bsky.social
Q: What do 40% of papers on animal stroke experiments have in common?

A: Fake data.

So found a study published Thursday in @plosbiology.org
journals.plos.org/plosbiology/...

🧪 #ResearchIntegrity #SciComment
High prevalence of articles with image-related problems in animal studies of subarachnoid hemorrhage and low rates of correction by publishers
Unchallenged erroneous articles can undermine scientific progress and mislead future research. This study shows that image-related issues affect 40% of reviewed articles on early brain injury in anima...
journals.plos.org
November 3, 2025 at 5:19 AM
yusk.bsky.social
参考程度に journals.plos.org/plosbiology/... を眺めている（病院の一般向け食生活ガイド記事からリンクされてた）
Glucotypes reveal new patterns of glucose dysregulation
Author summary One in 10 individuals is affected by diabetes, a condition involving abnormal regulation of blood glucose. Currently, diabetes is assessed using single-time or average measurements of b...
journals.plos.org
November 3, 2025 at 1:59 AM
gordonfernie.bsky.social
This article in PLOS Biology is very concerning: journals.plos.org/plosbiology/... Their conservative estimate is that 40% of preclinical studies in subarachnoid hemorrhage are problematic!
November 2, 2025 at 11:28 PM
jayhay.bsky.social
journals.plos.org/plosbiology/... wurde anhand Antikörperuntersuchungen geschätzt, dh es sind auch gering symptomatische Verläufe dabei
Estimating the Life Course of Influenza A(H3N2) Antibody Responses from Cross-Sectional Data
A combination of cross-sectional serological data from Southern China and mathematical modeling reveals key aspects of the human immune system's response to seasonal influenza infection.
journals.plos.org
November 2, 2025 at 6:29 AM
ultimape.bsky.wovensoup.com
"While 40% of the included articles were flagged as problematic, we have several reasons to propose that this is a conservative estimate. First, both visual and AI-driven detection methods have limitations."
journals.plos.org/plosbiology/...
High prevalence of articles with image-related problems in animal studies of subarachnoid hemorrhage and low rates of correction by publishers
Unchallenged erroneous articles can undermine scientific progress and mislead future research. This study shows that image-related issues affect 40% of reviewed articles on early brain injury in anima...
journals.plos.org
November 1, 2025 at 4:29 PM
natesherer.bsky.social
Congrats @jordanbeckerphd.bsky.social! journals.plos.org/plosbiology/...
Mammalian antiviral proteins ZAP and KHNYN can independently restrict CpG-enriched avian viruses
Zoonotic influenza A viruses pose a persistent threat, yet the antiviral barriers to cross-species transmission remain unclear. This study shows that CpG-enriched avian viruses are restricted by sever...
journals.plos.org
November 1, 2025 at 2:45 AM
nbdatapoints.bsky.social
Environmental DNA sampling suggests ranges of many marine species are greater than thought.

journals.plos.org/plosbiology/...
eDNA surveys substantially expand known geographic and ecological niche boundaries of marine fishes
Global species records often underestimate marine fish distributions due to sampling biases, especially in remote regions. This study shows that environmental DNA surveys significantly expand known ge...
journals.plos.org
November 1, 2025 at 1:15 AM
jamielarsh.bsky.social
Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection journals.plos.org/plosbiology/...
Brain-age models with lower age prediction accuracy have higher sensitivity for disease detection
There is increasing interest in developing imaging-based models to characterize 'brain-age', but how accurate are these for predicting neurological disease? This study shows that simpler models, which...
journals.plos.org
October 31, 2025 at 5:19 PM
sonjalehtinen.bsky.social
New(ish!) paper on how within-host competition and antibiotic resistance shape the fitness of Streptococcus pneumoniae serotypes, out in August in Plos Biology. journals.plos.org/plosbiology/...
Quantifying the effects of antibiotic resistance and within-host competition on strain fitness in Streptococcus pneumoniae
Competition significantly influences bacterial population dynamics, particularly in how strains interact within and between hosts. This study shows that within-host competition in Streptococcus pneumo...
journals.plos.org
October 31, 2025 at 3:05 PM