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Prenatal molecular genetic testing for familial variants that cause inherited disorders has been performed for decades and is accepted as standard of care. However, the spectrum of genes considered fo...

Hereditary repeat diseases are caused by an abnormal expansion of short tandem repeats in the genome. Among them, spinocerebellar ataxia (SCA) is a heterogeneous disease, and currently, 16 responsible...

Myeloid neoplasms are clonal disorders that arise via acquisition of genetic mutations leading to excessive proliferation and defective differentiation. Mutational profiling is vital as it has implica...

Alport syndrome is an inherited kidney disease, which can lead to glomerulosclerosis and fibrosis, as well as end-stage kidney disease in children and adults. Platelet-derived growth factor-D (PDGF-D)...

Climate tipping points were once a hypothetical risk in a distant future. After humanity spent the first quarter of the new century not sorting out climate change, we're now at the point where shit gets real. Tipping points will tip, and it's only a question of when, and how they will interact with each other. For instance, the Greenland ice sheet may topple the North Atlantic's AMOC (and thus the Gulf Stream), which in turn may kill the Amazon rain forest. Interesting times. I remember very vividly a climate workshop back in 2012 where we were told that AMOC was safe. I wrote a feature about it then. Now there is mounting evidence that AMOC is no longer stable and could pass its tipping point at any time. So I had to write another feature to correct my record on that. This feature is out now: **North Atlantic tipping point ahead** Current Biology Volume 34, Issue 5, 11 March 2024, Pages R175-R177 FREE access to full text and PDF download See also my Mastodon thread where I highlighted all CB features of 2024. The thread for 2023 is here . After recent rapid heating in the Arctic and accelerated melting of Greenland ice, the collapse of the Gulf Stream has become a real possibility. (Photo: Jennifer Latuperisa-Andresen/Unsplash.)

Dyslipolysis of adipocytes plays a critical role in various diseases. Adipose triglyceride lipase (ATGL) is a rate-limiting enzyme in adipocyte autonomous lipolysis. However, the degree of adipocyte lipolysis related to the prognoses in acute pancreatitis (AP) and the role of ATGL-mediated lipolysis in the pathogenesis of AP remain elusive. Herein, the visceral adipose tissue consumption rate in the acute stage was measured in both patients with AP and mouse models. Lipolysis levels and ATGL ...

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Low-grade serous carcinoma (LGSC) may develop from serous borderline tumor (SBT) tissue, where the micropapillary type (mSBT) presents the highest risk for progression. The sensitivity of LGSC to stan...

During the plague years I have often mentioned that things like virus fragments can be readily detected in wastewater, and that with the same methodology researchers can also describe the distribution of drug use, eg for cocaine. This is quite routine now, but what amazingly hasn't been done very often is to look at the impact our drugs - including the legal as well as the illegal kind - have on ecosystems when they escape into the water systems. The first global survey attempting to estimate the impacts of drug pollution in the environment only happened two years ago. So I thought this endeavour could do with a bit of a shout-out, which is why it is the subject of my latest feature, out now: **Drugging the biosphere** Current Biology Volume 34, Issue 13, 8 July 2024, Pages R605-R607 FREE access to full text and PDF download See also my Mastodon thread where I highlighted all CB features of 2024. The thread for 2023 is here . A wide variety of drugs is helping us to stay healthy for longer, but the effects the active ingredients may have on other species after our use are too little understood. (Photo: Myriam Zilles/Unsplash.)

Об’єкт дослідження: система комплексної обробки оптичних, інфрачервоних, акустичних і радіолокаційних сигналів, які випромінюються або відбиваються БПЛА, в умовах дії пасивних і активних шумових завад...