#Nrf2
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iib.uam.es
💡 Session 1 chaired by Pilar López: exploring neuroscience, metabolism, and molecular mechanisms❗

🔷Ana Rojo: Role of NRF2
🔷Francesc García: Joubert Syndrome and INPP5E
🔷Antonio Barbáchano: Patient-derived organoids
🔷Adrián Povo: Immune metabolism under cancer drug treatment
November 8, 2025 at 1:33 PM
sciencex.bsky.social
Biliverdin reductase A has been shown to protect neurons from oxidative stress by regulating NRF2, independent of its role in bilirubin production, suggesting new avenues for neurodegenerative disease therapies. doi.org/g983z7
Protein plays unexpected dual role in protecting brain from oxidative stress damage
New research from Johns Hopkins Medicine shows that the enzyme biliverdin reductase A (BVRA) plays a direct protective role against oxidative stress in neurons, independent of its role producing the yellow pigment bilirubin.
medicalxpress.com
November 3, 2025 at 8:47 PM
ralfwittenbrink.bsky.social
Entzündungsreaktionen ausgelöst werden, sondern auch in anderen Organen. So greift SARS-CoV-2 über die entstehende Entzündungsreaktion indirekt auch das Herz und die Gefäße an; noch Monate nach einer schweren Covid-Infektion ist deshalb das Risiko für einen Herzinfarkt erhöht.
Figure 1 Pathogens such as COVID-19 by inhalation of the virus affect number of organs in the body (left picture). Organ damage is determined by the balance between the activation of hazardous mechanisms and protective mechanisms. ADMA, asymmetrical dimethylarginine; Angll, angiotensin Il; Angpt-2, angiopoietin-2; CAT, catalase; EDHF, endothelium-derived hyperpolarizing factor; eNOS, endothelial nitric oxide synthase; ET-1, endothelin 1; GCH1, GTP cyclohydrolase 1; H2S, hydrogen sulfide; HO-1, heme oxygenase-1; ICAM1, intercellular adhesion molecule 1; KLF2, krüppel-like factor 2; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; PAI-1, plasminogen activator inhibitor 1; PG|,, prostaglandin 12; ROS, reactive oxygen species; SASP, senescence-associated secretory phenotype; SOD, superoxide dismutase; TF, tissue factor; Thbd, thrombomodulin; Tie-2, tyrosine-protein kinase receptor; t-PA, tissue plasminogen activator; Tx-A2, thromboxane A2; u-PA, urokinase plasminogen activator; VCAM1, vascular cell adhesion molecule 1; vWF, von Willebrand factor. Modified from Xu et al."9
November 3, 2025 at 4:49 PM
lozanzi.bsky.social
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
oceanedufies.bsky.social
#SpookyInflammasome 🎃
With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis.
... more to come on the priming !
October 31, 2025 at 5:37 PM
csbj.org
🔗 RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2. Computational and Structural Biotechnology Journal, doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #PeptideTherapeutics #RoseTTAFold #ProteinEngineering #MolecularDynamics #DrugDesign
RoseTTAFold diffusion-guided short peptide design: a case study of binders against Keap1/Nrf2. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.02.032
October 31, 2025 at 12:35 AM
viennaairwaylab.bsky.social
📣 Join our webinar 🖥️ today to hear about biomarkers 🧬 of #NRF2 activation and their role in fighting chronic diseases 💊

@benbedphar.bsky.social
#BenBedPhar #COST #NRF2 #redox

🔗 www.antiox.it/webinars2025...
October 28, 2025 at 6:19 AM
lmg622.bsky.social
NRF2 and Estrogen Roles in #BRCA1 #BreastCancer
Via @bioengineer.org

#bcsm #hereditarycancer #womenshealth #genetics #cancerresearch #medsky
NRF2 and Estrogen Roles in BRCA1 Breast Cancer
Breast cancer remains the most frequently diagnosed malignancy among women worldwide, posing a significant threat to public health despite ongoing advances in detection and treatment. Approximately 5
bioengineer.org
October 24, 2025 at 4:46 PM
viennaairwaylab.bsky.social
📚 Our new review is out! @benbedphar.bsky.social WG3 dives deep into measuring #NRF2 activity across diseases and how to translate these biomarkers into clinical practice for better patient care.
Massive thanks to the fantastic team behind this work! 🙌
#NCD #COST #stress

🔗 doi.org/10.1016/j.re...
October 14, 2025 at 7:46 AM
viennaairwaylab.bsky.social
A fantastic finale at Kadir Has Istanbul for the #BenBedPhar MC&Scientific Meeting. Delivered WG3 report, presented our new research, and chaired #NRF2 scientific session. Grateful for an incredible 4 years with this brilliant #COST Action community—a truly unique journey 🎉
@benbedphar.bsky.social
October 11, 2025 at 2:10 PM
microbesinfect.bsky.social
Immunometabolic reprogramming of macrophages by gut #microbiota-derived cadaverine controls colon #inflammation.

Cadaverine rewires macrophage metabolism via Nrf2 activation. Concentration dictates anti- or pro-inflammatory outcomes.

www.cell.com/cell-host-mi... #MicroSky #ImmunoSky
October 5, 2025 at 2:07 PM
lozanzi.bsky.social
#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine 🧟‍♂️ controls macrophage metabolism & gut inflammation. Low 🧟‍♂️ activates NRF2 promoting OXPHOS & homeostasis, while high 🧟‍♂️ drives glycolysis & intestinal inflammation 🔥 !!
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation
de Oliveira Formiga et al. present that gut-microbiota-derived cadaverine reprograms macrophage energy metabolism in a concentration-dependent fashion, promoting either anti- or pro-inflammatory immun...
www.cell.com
October 4, 2025 at 3:07 PM
jimmunol.bsky.social
RTA-480 is currently a therapeutic for Friedrich’s Ataxia that activates NRF2. Researchers explored the therapeutic potential of RTA-408 in #IBD, finding that it modulates T cell homeostasis, metabolism, and inflammation. Learn more: ow.ly/kKKf50X32sk.
Therapeutic potential of NRF2 activating drug RTA-408 in suppressing T cell effector responses and inflammatory bowel disease
Abstract. RTA-408, also known as Omaveloxolone, is an FDA-approved drug for treating Friedrich’s Ataxia, a neurological disorder. It is a triterpenoid comp
ow.ly
October 1, 2025 at 9:32 PM
atranscendedman.bsky.social
Shanghai East Hospital studied 30 mice given gut bacteria from 21 severe COVID patients.

Ozone water enemas restored gut balance, reduced inflammation, and protected lungs and liver by activating the SIRT1 Nrf2 HO-1 pathway.

www.microbiologyresearch.org/content/jour...
Ozone water enema activates SIRT1-Nrf2/HO-1 pathway to ameliorate gut dysbiosis in mice receiving COVID-19 patient-derived faecal microbiota
Introduction. This study centres on how coronavirus disease 2019 (COVID-19) disrupts the intestinal microbiota and amplifies systemic inflammation and evaluates ozone water enemas as a strategy to res...
www.microbiologyresearch.org
September 17, 2025 at 5:03 PM
benbedphar.bsky.social
We are pleased to announce the next BenBedPhar Webinar:
“NRF2 and Aging: Proteostasis and Redox Imbalance”
🗓 Tuesday, 30 September 2025
🕒 3:00 PM – 5:00 PM (CEST)
This webinar will explore the role of NRF2 in the aging process and age-related diseases. Registration: www.antiox.it/home-redox/
Home Redox – Antiox.it
www.antiox.it
September 16, 2025 at 6:53 AM
biorxiv-neursci.bsky.social
YPEL controls synapse development through p62-Nrf2 antioxidant pathway in Drosophila neuromuscular junction https://www.biorxiv.org/content/10.1101/2025.04.07.647271v1
April 8, 2025 at 3:16 AM
mattsiegel.bsky.social
@maddiequestions.bsky.social i've been reading up on potential ALS causes and treatments, and:

"By lowering the generation of oxidative stress, pharmacological therapies targeting Nrf2 activation might provide a neuroprotective effect in patients with ALS."
November 26, 2024 at 2:58 PM
biorxivpreprint.bsky.social
CILP from Cartilage Intermediate Zone Inhibits Hyaline Cartilage Fibrosis and Chondrocyte Ferroptosis via Keap1-Nrf2 Axis in Early Osteoarthritis Exercise Therapy https://www.biorxiv.org/content/10.1101/2024.11.02.621635v1
CILP from Cartilage Intermediate Zone Inhibits Hyaline Cartilage Fibrosis and Chondrocyte Ferroptosis via Keap1-Nrf2 Axis in Early Osteoarthritis Exercise Therapy https://www.biorxiv.org/content/10.1101/2024.11.02.621635v1
By analyzing the single-cell RNA-Seq libraries, the roles of cartilage intermediate layer protein (C
www.biorxiv.org
November 4, 2024 at 7:30 AM
wellnesscd.bsky.social
⚫ Nrf2 Activation: Boosts antioxidant defenses and reduces inflammation through the Nrf2 pathway.
⚫ Collagen Synthesis: Stimulates fibroblasts for improved skin health and wound healing.
⚫ Pain Relief: Reduces inflammation and enhances tissue repair, alleviating pain.
February 25, 2025 at 4:40 PM
vjsanchez.bsky.social
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive #PancreaticCancer 🧪 www.nature.com/articles/s43...
Self-amplifying NRF2–EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer - Nature Cancer
Using pancreatic organoids and genetic mouse models, Antonucci et al. show that cellular stress activates an NRF2–EZH2 epigenetic axis leading to metabolic reprogramming and subsequent malignant trans...
www.nature.com
July 1, 2025 at 6:45 AM
helixbrief.bsky.social
The chaperone response was regulated by the transcriptional regulators HSF1 and NRF2.
August 27, 2025 at 4:26 AM
biorxivpreprint.bsky.social
Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2. https://www.biorxiv.org/content/10.1101/2025.01.29.635299v1
January 30, 2025 at 2:33 AM
biorxiv-cellbio.bsky.social
Cannabis sativa (Hemp) seed-derived peptides WVYY and PSLPA modulate the Nrf2 signaling pathway in human keratinocytes https://www.biorxiv.org/content/10.1101/2024.01.26.577509v1
Cannabis sativa (Hemp) seed-derived peptides WVYY and PSLPA modulate the Nrf2 signaling pathway in human keratinocytes https://www.biorxiv.org/content/10.1101/2024.01.26.577509v1
Cannabis sativa (Hemp) seeds are used widely for cosmetic and therapeutic applications, and contain
www.biorxiv.org
January 28, 2024 at 1:31 AM
lsajournal.org
A novel NRF2 activator in combination with an angiotensin receptor blocker prominently prolonged the lifespan of an Alport syndrome mouse model.
www.life-science-alliance.org/content/8/8/...
June 18, 2025 at 5:55 PM