Accelerated long-term forgetting (ALF) is the rapid loss of newly-learnt information, typically noticeable after ~30minutes, and observed across diver…

Beyond direct injuries, exposure to tropical cyclones is associated with higher risks of death across a range of causes including kidney, heart and lung diseases, neuropsychiatric conditions, and diabetes, finds a study published in The BMJ's climate issue.

Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders.

Strep throat is a common childhood illness, but in a few children this bacteria infection can lead to alarming, lasting changes in behaviour.

Neuropsychiatry has yet to surmount the fundamental challenge of mapping behavioral pathology to its underlying neural pathology. This gap limits the development of treatments for specific circuit pat...

The Anambra State graduates of Enugu State University, (ESUT), ASGRET, celebrated the 2025 world mental health day with a warm visit to the Anambra state Neuropsychiatric hospital, Nawfia where they had an emotional but fulfilling encounter with those suffering from different ranges of mental health challenges. Today, 10th of October each year is set aside globally for the awareness creation of mental health illnesses.

People with the inflammatory skin disease are at greater risk of neuropsychiatric conditions. Researchers are trying to find out why.

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Background Neuropsychiatric disorders are highly complex conditions and the risk of developing a disorder has been tied to hundreds of genomic variants that alter the expression and/or RNA isoforms made by risk genes. However, how these genes contribute to disease risk and onset through altered expression and RNA splicing is not well understood. Results Combining our new bioinformatic pipeline IsoLamp with nanopore long-read amplicon sequencing, we deeply profile the RNA isoform repertoire of 31 high-confidence neuropsychiatric disorder risk genes in Human brain. We show most risk genes are more complex than previously reported, identifying 363 novel isoforms and 28 novel exons, including isoforms which alter protein domains, and genes such as ATG13 and GATAD2A where most expression was from previously undiscovered isoforms. The greatest isoform diversity is detected in the schizophrenia risk gene ITIH4. Mass spectrometry of brain protein isolates confirms translation of a novel exon skipping event in ITIH4, suggesting a new regulatory mechanism for this gene in the brain. Conclusions Our results emphasize the widespread presence of previously undetected RNA and protein isoforms in the human brain and provide an effective approach to address this knowledge gap. Uncovering the isoform repertoire of candidate neuropsychiatric risk genes will underpin future analyses of the functional impact these isoforms have on neuropsychiatric disorders, enabling the translation of genomic findings into a pathophysiological understanding of disease.

This Special Communication addresses the concerns that psychiatrists and other mental health professionals can have when assisting patients who are facing psychiatric disorders associated with restric...

Long COVID presents with a wide range of persistent symptoms and durations following COVID-19 infection. However, data on children and adolescents remain limited. This study aims to explore visual per...