Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
October 6, 2025 at 11:43 AM
Best practices & tools in R & Python for statistical processing and visualization of #Lipidomics & #Metabolomics data
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
Data imputation/normalization
Batch correction
Data visualization
Statistical models
Instrumental handbook, adoptable for other omics
#NatComms 2025
www.nature.com/articles/s41...
What a week last week:
🤓 NatComms paper corrections resubmitted.
🎉 Reached >17K people for the first time with something I love: making papers easy to understand.
👨🏽⚕️Dr confirms worrying issue was nothing to worry.
💸 ETH hits all time high.
But I need to tell you this:
🤓 NatComms paper corrections resubmitted.
🎉 Reached >17K people for the first time with something I love: making papers easy to understand.
👨🏽⚕️Dr confirms worrying issue was nothing to worry.
💸 ETH hits all time high.
But I need to tell you this:
August 27, 2025 at 11:36 AM
What a week last week:
🤓 NatComms paper corrections resubmitted.
🎉 Reached >17K people for the first time with something I love: making papers easy to understand.
👨🏽⚕️Dr confirms worrying issue was nothing to worry.
💸 ETH hits all time high.
But I need to tell you this:
🤓 NatComms paper corrections resubmitted.
🎉 Reached >17K people for the first time with something I love: making papers easy to understand.
👨🏽⚕️Dr confirms worrying issue was nothing to worry.
💸 ETH hits all time high.
But I need to tell you this:
This time, we are comparing Deep Seek R1, DeepSeek V3, Grok 3, Llama 3.3 70B, Gemini 2.5 Pro, and GPT-4o on Daszak's calendar items about NatComms.
DeepSeek R1 regularly surprises (image).
@PeterDaszak @sciencecohen @Lake_Octopus @R_H_Ebright @emilyakopp @thackerpd @mattwridley
DeepSeek R1 regularly surprises (image).
@PeterDaszak @sciencecohen @Lake_Octopus @R_H_Ebright @emilyakopp @thackerpd @mattwridley
July 22, 2025 at 5:26 AM
This time, we are comparing Deep Seek R1, DeepSeek V3, Grok 3, Llama 3.3 70B, Gemini 2.5 Pro, and GPT-4o on Daszak's calendar items about NatComms.
DeepSeek R1 regularly surprises (image).
@PeterDaszak @sciencecohen @Lake_Octopus @R_H_Ebright @emilyakopp @thackerpd @mattwridley
DeepSeek R1 regularly surprises (image).
@PeterDaszak @sciencecohen @Lake_Octopus @R_H_Ebright @emilyakopp @thackerpd @mattwridley
This is nice, Jen! Could it be also accumulation issue at edge? For example, is there a higher expression of biosynthetic gene or is it only local metabolism and pH differences?
Lucky your incubator does not allow light in, right? In view of recent Kobayashi NatComms paper…
Lucky your incubator does not allow light in, right? In view of recent Kobayashi NatComms paper…
July 22, 2025 at 4:33 AM
This is nice, Jen! Could it be also accumulation issue at edge? For example, is there a higher expression of biosynthetic gene or is it only local metabolism and pH differences?
Lucky your incubator does not allow light in, right? In view of recent Kobayashi NatComms paper…
Lucky your incubator does not allow light in, right? In view of recent Kobayashi NatComms paper…
New manuscript describing a modified auxin-inducible degron system ‘AID2.1’ just out in @NatComms. www.nature.com/articles/s41.... It's worth checking out the comments of Reviewer 1 in the peer review file for this one before jumping aboard...
Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology - Nature Communications
Traditional genetic perturbation tools such as siRNA and CRISPR knockout operate on timescales that render them unsuitable for exploring dynamic processes or studying essential genes, where chronic de...
www.nature.com
July 21, 2025 at 11:33 AM
New manuscript describing a modified auxin-inducible degron system ‘AID2.1’ just out in @NatComms. www.nature.com/articles/s41.... It's worth checking out the comments of Reviewer 1 in the peer review file for this one before jumping aboard...
Global increase in the endemism of birds from north to south #natcomms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Global increase in the endemism of birds from north to south - Nature Communications
Global patterns of endemism (irreplaceability) are still not well known. This study shows that endemism of birds increases from north to south, and highlights the vulnerability of southern hemisphere ...
www.nature.com
July 14, 2025 at 10:01 AM
Global increase in the endemism of birds from north to south #natcomms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Improving human papillomavirus vaccination coverage in France: a need to act but not to rush #natcomms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Improving human papillomavirus vaccination coverage in France: a need to act but not to rush - Nature Communications
Suboptimal vaccine uptake is a worldwide public health issue. We need (i) to develop interventional population health research on vaccine uptake and (ii) to ensure better use of the research results b...
www.nature.com
June 25, 2025 at 8:24 AM
Improving human papillomavirus vaccination coverage in France: a need to act but not to rush #natcomms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
For the DNA polymerase θ afficionados: www.nature.com/articles/s41... This N&Vs by Sylvie Doublié nicely contextualises the progress imparted by this NSMB paper www.nature.com/articles/s41... by @landerlab.bsky.social and this NatComms paper www.nature.com/articles/s41... by the Chen/Pomerantz labs
Making 3′ ends meet - Nature Structural & Molecular Biology
Two papers offer a first glimpse at complexes of the helicase-like domain of DNA polymerase θ (Polθ-HD) bound to DNA. Together, they provide structural insights into how the dimeric form of Polθ-HD gr...
www.nature.com
May 27, 2025 at 12:22 PM
For the DNA polymerase θ afficionados: www.nature.com/articles/s41... This N&Vs by Sylvie Doublié nicely contextualises the progress imparted by this NSMB paper www.nature.com/articles/s41... by @landerlab.bsky.social and this NatComms paper www.nature.com/articles/s41... by the Chen/Pomerantz labs
El nuevo estudio del #CNB-CSIC @csic.es y @idisba.bsky.social a.bsky.social respalda el uso restringido de la combinación ceftazidima-avibactam para el tratamiento de infecciones de P. aeruginosa multirresistentes muy particulares
@hernando-amado.bsky.social
bit.ly/3EeQK8w
NatComms: bit.ly/4i5s7Ja
@hernando-amado.bsky.social
bit.ly/3EeQK8w
NatComms: bit.ly/4i5s7Ja
April 9, 2025 at 9:23 AM
El nuevo estudio del #CNB-CSIC @csic.es y @idisba.bsky.social a.bsky.social respalda el uso restringido de la combinación ceftazidima-avibactam para el tratamiento de infecciones de P. aeruginosa multirresistentes muy particulares
@hernando-amado.bsky.social
bit.ly/3EeQK8w
NatComms: bit.ly/4i5s7Ja
@hernando-amado.bsky.social
bit.ly/3EeQK8w
NatComms: bit.ly/4i5s7Ja
Here an overview of our #translational research on samples from the #NAPHER2 trial recently published in #NatComms @natureportfolio.nature.com. We identified #predictive #biomarkers and molecular dynamics in HER2+ER+ #breastcancer receiving chemo-free #targeted #treatment 👇
Analysis of molecular data from the NA-PHER2 trial, led from Michelangelo researchers identified new biomarkers predictive of response in HER2+/ER+ breast cancer patients receiving targeted treatments
www.fondazionemichelangelo.org/2025/03/10/n...
www.fondazionemichelangelo.org/2025/03/10/n...
New insights into the drivers and dynamics of HER2+/ER+ breast cancer response to targeted treatments - Fondazione Michelangelo
Analysis of molecular data from the NA-PHER2 trial, led by Fondazione Michelangelo researchers, identified new biomarkers predictive of response in HER2+/ER+ breast cancer patients receiving targeted ...
www.fondazionemichelangelo.org
March 10, 2025 at 12:28 PM
Here an overview of our #translational research on samples from the #NAPHER2 trial recently published in #NatComms @natureportfolio.nature.com. We identified #predictive #biomarkers and molecular dynamics in HER2+ER+ #breastcancer receiving chemo-free #targeted #treatment 👇
Congrats to #RueggLab and colleagues on their new #NatComms paper: Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. #Myoblue tinyurl.com/yeynb3t2
Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance - Nature Communications
Here they use single nuclei RNA-seq to identify transcripts in skeletal muscle that maintain the neuromuscular junction, both under normal and denervated conditions, which allows them to characterize ...
tinyurl.com
March 6, 2025 at 12:33 PM
Congrats to #RueggLab and colleagues on their new #NatComms paper: Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. #Myoblue tinyurl.com/yeynb3t2
🔧 DNA Glycosylases are essential in the base excision repair process, helping maintain genetic stability by removing damaged bases. What does that look like at single-molecule level?
Discover the recent NatComms paper on the dynamic activities of DNA Glycosylases in our recent blog post:
Discover the recent NatComms paper on the dynamic activities of DNA Glycosylases in our recent blog post:
Deciphering the Dynamic Mechanisms of Thymine DNA Glycosylase (TDG) in DNA Repair – LUMICKS
lumicks.com
February 28, 2025 at 12:14 PM
🔧 DNA Glycosylases are essential in the base excision repair process, helping maintain genetic stability by removing damaged bases. What does that look like at single-molecule level?
Discover the recent NatComms paper on the dynamic activities of DNA Glycosylases in our recent blog post:
Discover the recent NatComms paper on the dynamic activities of DNA Glycosylases in our recent blog post:
Delighted to post our most recent paper in @natcomms lead by @SimonaPunzi, within the frame of an Accelerator grant funded by @CRUK and @AIRC.
rdcu.be/d8r7j
rdcu.be/d8r7j
Early tolerance and late persistence as alternative drug responses in cancer
Nature Communications - Bacteria are able to withstand antibiotic treatment through three mechanisms, resistance, persistence or tolerance. Here, the authors investigate whether such mechanisms as...
rdcu.be
February 4, 2025 at 9:39 PM
Delighted to post our most recent paper in @natcomms lead by @SimonaPunzi, within the frame of an Accelerator grant funded by @CRUK and @AIRC.
rdcu.be/d8r7j
rdcu.be/d8r7j
Reproducibility and transparency: what’s going on and how can we help #natcomms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reproducibility and transparency: what’s going on and how can we help - Nature Communications
Problems with experimental reproducibility affect every field of science. However, the opinions on the causes of the reproducibility “crisis” and how we all can help vary amongst fields as well as ind...
www.nature.com
January 28, 2025 at 1:26 PM
Reproducibility and transparency: what’s going on and how can we help #natcomms
www.nature.com/articles/s41...
www.nature.com/articles/s41...
So happy to see this published in NatComms! tinyurl.com/yc66amvu Rare variant assocs with birth weight identify 9 genes. Insights into links between earlygrowth & later metabolic health. Great collabs between teams Exe&Camb. Amazing resources of UKB & deCODE made it possible.
Rare variant associations with birth weight identify genes involved in adipose tissue regulation, placental function and insulin-like growth factor signalling - Nature Communications
An exome-wide association study for fetal and maternal rare deleterious variants affecting the normal variation in birth weight identifies nine genes involved in adipose tissue regulation, placental f...
tinyurl.com
January 19, 2025 at 12:37 PM
So happy to see this published in NatComms! tinyurl.com/yc66amvu Rare variant assocs with birth weight identify 9 genes. Insights into links between earlygrowth & later metabolic health. Great collabs between teams Exe&Camb. Amazing resources of UKB & deCODE made it possible.
I view the "innovation" of eLife as rebranding of things they wouldn't get attention/credit for if they didn't rebrand. Accepting everything after editorially rejecting 70% isn't erased by then publishing everything. Publication is also already accomplished by preprints. NatComms openly reviews.
December 21, 2024 at 10:31 PM
I view the "innovation" of eLife as rebranding of things they wouldn't get attention/credit for if they didn't rebrand. Accepting everything after editorially rejecting 70% isn't erased by then publishing everything. Publication is also already accomplished by preprints. NatComms openly reviews.
Curious what it's like to be a full time editor? 📖 (Hint: it's freaking awesome).
Come find me this week at #agu24.
The Nature Portfolio is always on the lookout for new talent....and my Earth team at NatComms is hiring 👀
#science @natureportfolio.bsky.social @naturecomms.bsky.social
Come find me this week at #agu24.
The Nature Portfolio is always on the lookout for new talent....and my Earth team at NatComms is hiring 👀
#science @natureportfolio.bsky.social @naturecomms.bsky.social
December 10, 2024 at 3:34 PM
Curious what it's like to be a full time editor? 📖 (Hint: it's freaking awesome).
Come find me this week at #agu24.
The Nature Portfolio is always on the lookout for new talent....and my Earth team at NatComms is hiring 👀
#science @natureportfolio.bsky.social @naturecomms.bsky.social
Come find me this week at #agu24.
The Nature Portfolio is always on the lookout for new talent....and my Earth team at NatComms is hiring 👀
#science @natureportfolio.bsky.social @naturecomms.bsky.social
A nice public dissemination piece based on our article in NatComms, "Mid-Pleistocene aridity and landscape shifts promoted Palearctic hominin dispersals"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
While it's true that humans have previously faced climate change, these were way slower, and never easy.
While it's true that we can survive hardship feeling stronger, not everybody does
what happened last time?
climateages.com/early-humans...
While it's true that we can survive hardship feeling stronger, not everybody does
what happened last time?
climateages.com/early-humans...
Early Humans Thrived in Changing Climates—But It Wasn't Easy - Climate Ages
What past climate change reveals about human resilience Raise your hand if you can’t wait to face another hardship so that you can thrive from...
climateages.com
December 9, 2024 at 8:21 PM
A nice public dissemination piece based on our article in NatComms, "Mid-Pleistocene aridity and landscape shifts promoted Palearctic hominin dispersals"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Remains to be seen if it would work when going up the IF ladder (e.g. to NHB/NatComms, TICS, or Neuron), though it seems possible given how quickly a new "Nature" journal amasses prestige. And I'm still foggy on what it would take to divorce society journals from their current for-profit publishers.
November 30, 2024 at 8:12 PM
Remains to be seen if it would work when going up the IF ladder (e.g. to NHB/NatComms, TICS, or Neuron), though it seems possible given how quickly a new "Nature" journal amasses prestige. And I'm still foggy on what it would take to divorce society journals from their current for-profit publishers.
Really happy to share that our latest work on "Higher order connectomics of human brain function" is now out in NatComms @naturecomms.bsky.social. One of the most fun projects that I've worked on! Big thanks to the friends involved F Battiston, M Lucas, @lordgrilo.bsky.social, E Amico doi.org/nt34
Higher-order connectomics of human brain function reveals local topological signatures of task decoding, individual identification, and behavior - Nature Communications
Here, the authors perform a higher-order analysis of fMRI data, revealing that accounting for group interactions greatly enhances task decoding, brain fingerprinting, and brain-behavior associations c...
www.nature.com
November 28, 2024 at 9:35 AM
Really happy to share that our latest work on "Higher order connectomics of human brain function" is now out in NatComms @naturecomms.bsky.social. One of the most fun projects that I've worked on! Big thanks to the friends involved F Battiston, M Lucas, @lordgrilo.bsky.social, E Amico doi.org/nt34
Thrilled to share my latest work "Microstructural asymmetry in the human cortex" now out in NatComms. www.nature.com/articles/s41...
This work used cytoarchitecture (BigBrain), T1w/T2w, qT1, and MT measures to bring the cortical asymmetry from macrostructure to microstructure.
This work used cytoarchitecture (BigBrain), T1w/T2w, qT1, and MT measures to bring the cortical asymmetry from macrostructure to microstructure.
Microstructural asymmetry in the human cortex - Nature Communications
The human cortex displays an anterior-to-posterior asymmetry, identified via both post-mortem and in vivo microstructural measurements. Microstructural asymmetry is heritable, varies across cortical l...
www.nature.com
November 25, 2024 at 12:41 PM
Thrilled to share my latest work "Microstructural asymmetry in the human cortex" now out in NatComms. www.nature.com/articles/s41...
This work used cytoarchitecture (BigBrain), T1w/T2w, qT1, and MT measures to bring the cortical asymmetry from macrostructure to microstructure.
This work used cytoarchitecture (BigBrain), T1w/T2w, qT1, and MT measures to bring the cortical asymmetry from macrostructure to microstructure.
Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...
A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma - Nature Communications
Epigenetic causes of intra-tumoural heterogeneity are crucial in paediatric cancers with low mutation rates, such as hepatoblastoma. Here, the authors characterise transcriptional heterogeneity in hep...
www.nature.com
November 20, 2024 at 2:29 PM
Happy to be here & share our work on hepatoblastoma - using transcriptomics and patient-derived tumoroids to identify embryonic biliary transcription factor SOX4 as a modifier of Wnt activation & proliferation - published today in #NatComms @natureportfolio.bsky.social www.nature.com/articles/s41...
Being a NatComms editor myself, that hurts a bit. Thousands of manuscripts are submitted to our journal every year. Concluding "very poor editorial handling seems to be a theme" from 2 cases in 4-5 years sounds a bit unfair to me...
November 20, 2024 at 9:45 AM
Being a NatComms editor myself, that hurts a bit. Thousands of manuscripts are submitted to our journal every year. Concluding "very poor editorial handling seems to be a theme" from 2 cases in 4-5 years sounds a bit unfair to me...
Cool new work from Pierre Gautrat and @ronaldpierik.bsky.social in Natcomms on root-to-shoot signaling via cytokinin, regulating shade avoidance responses and nutrient acquisition. So complex! 😱
www.nature.com/articles/s41...
#PlantSci #PlantScience
www.nature.com/articles/s41...
#PlantSci #PlantScience
Phytochrome-dependent responsiveness to root-derived cytokinins enables coordinated elongation responses to combined light and nitrate cues - Nature Communications
The authors here investigate information integration in plants using light and nutrient stimuli and identify a novel regulation pathway towards photoreceptor-regulated stem growth.
www.nature.com
October 3, 2024 at 1:18 PM
Cool new work from Pierre Gautrat and @ronaldpierik.bsky.social in Natcomms on root-to-shoot signaling via cytokinin, regulating shade avoidance responses and nutrient acquisition. So complex! 😱
www.nature.com/articles/s41...
#PlantSci #PlantScience
www.nature.com/articles/s41...
#PlantSci #PlantScience
Bacteria in lakes fight climate change! 🦠🏞️
#Methane-oxidizing bacteria #MOB prevent the release of #CH4 from lakes better than thought. Read who is behind the process and how it works.
mpi-bremen.de/en/Bacteria-...
Out now @natureportfolio.bsky.social NatComms
#Methane-oxidizing bacteria #MOB prevent the release of #CH4 from lakes better than thought. Read who is behind the process and how it works.
mpi-bremen.de/en/Bacteria-...
Out now @natureportfolio.bsky.social NatComms
Bacteria in lakes fight climate change
mpi-bremen.de
August 13, 2024 at 12:25 PM
Bacteria in lakes fight climate change! 🦠🏞️
#Methane-oxidizing bacteria #MOB prevent the release of #CH4 from lakes better than thought. Read who is behind the process and how it works.
mpi-bremen.de/en/Bacteria-...
Out now @natureportfolio.bsky.social NatComms
#Methane-oxidizing bacteria #MOB prevent the release of #CH4 from lakes better than thought. Read who is behind the process and how it works.
mpi-bremen.de/en/Bacteria-...
Out now @natureportfolio.bsky.social NatComms